Link test--A statistical method for finding prostate cancer biomarkers

We present a new method, link-test, to select prostate cancer biomarkers from SELDI mass spectrometry and microarray data sets. Biomarkers selected by link-test are supported by data sets from both mRNA and protein levels, and therefore results in improved robustness. Link-test determines the level of significance of the association between a microarray marker and a specific mass spectrum marker by constructing background mass spectra distributions estimated by all human protein sequences in the SWISS-PROT database. The data set consist of both microarray and mass spectrometry data from prostate cancer patients and healthy controls. A list of statistically justified prostate cancer biomarkers is reported by link-test. Cross-validation results show high prediction accuracy using the identified biomarker panel. We also employ a text-mining approach with OMIM database to validate the cancer biomarkers. The study with link-test represents one of the first cross-platform studies of cancer biomarkers.     

Photoelectrochemical study on charge transfer properties of TiO2-B nanowires with an application as humidity sensors

One-dimensional (1-D) TiO2-B nanowires have been synthesized via a facile solvothermal route. The morphology and crystalline structures of the nanowires were characterized by using powder X-ray diffraction, low/high-resolution transmission electron microscopy, and Brunauer-Emmett-Teller methods. It is important with the calcination treatment at 350 degrees C to maintain 1-D morphologies of the material in the form of single-crystalline TiO2-B nanowires. In addition, a simple method was used to study the photogenerated charge transfer and photoelectrochemical properties of the TiO2-B nanowires in comparison with commercial TiO2 P25 nanoparticles based on the experimental data from the electric field-effected photocurrent action spectrum and Mott-Schottky measurements. It was revealed that TiO2-B nanostructures played an important role in the photoelectrochemical processes. The synthetic TiO2-B nanowire electrode exhibited unique electronic properties, e.g., favorable charge-transfer ability, negative-shifted appearing flat-band potential, existence of abundant surface states or oxygen vacancies, and high-level dopant density. Moreover, the obtained TiO2-B nanowires were found to display excellent humidity sensing abilities as functional materials in the humidity sensor application. With relative humidity increased from 5% to 95%, about one and half orders of magnitude change in resistance was observed in the TiO2-B nanowire-based surface-type humidity sensors.     

First-principle band structure calculations of tris(8-hydroxyquinolinato)aluminum

Tris(8-hydroxyquinolinato)aluminum (Alq(3)) has been widely used in organic light-emitting diodes (OLEDs) both as electron transport and light-emitting materials. To gain a deeper understanding for its carrier transport properties, we carry out first-principle band-structure calculations using density-functional theory with generalized gradient approximation by the Becke exchange plus Lee-Yang-Parr correlation functional. The intermolecular interaction related to transport behavior has been analyzed from the Gamma-point wave function as well as from the bandwidths and band gaps. From the calculated bandwidths of the frontier bands as well as the effective masses of the electron and the hole, we conclude that the mobility of electron is about 2-3 times larger than that for the hole. Furthermore, when several bands near Fermi surface are taken into account, we find that the interband gaps within the unoccupied bands are generally smaller than those for the occupied bands, which indicate that the electron can hop from one band to another, much easier than the hole, through electron-phonon coupling for instance, thus, effectively representing an even larger mobility for the electron than for the hole. Therefore, from both the intra-band and inter-band processes point of view, the theory shows that that Alq(3) is a good electron transport material.     

脑血栓形成患者用精制蝮蛇抗栓酶(Svate-3)治疗前后头发微量元素分析

对１２６例脑血栓形成患者用精制蝮蛇抗栓酶（Ｓｖａｔｅ－３）治疗，检测用药前后头发中Ｃｒ、Ｍｎ、Ｓｅ、Ｍｏ、Ｃｏ元素含量。发现脑血检患者用Ｓｖａｔｅ－３治疗后发Ｃｒ、Ｍｎ、Ｓｅ含量明显高于用药前，它们之间都有显著性差异，Ｐ＜０．０１；Ｍｏ、Ｃｏ元素的含量在用药前后无显著性差异Ｐ＞０．０５，提示发Ｃｒ、Ｍｎ、Ｓｅ与脑血栓有关。     

经翼点入路显微手术切除蝶骨嵴脑膜瘤

目的:探讨经翼点入路显微手术切除蝶骨嵴脑膜瘤的方法及周围神经血管保护问题,提高蝶骨嵴脑膜瘤治疗效果。方法:采用显微神经外科技术,经常规翼点或扩大翼点入路,切除蝶骨嵴脑膜瘤。结果:按Simpson分级法评价肿瘤的切除程度:Ⅰ级切除5例,Ⅱ级切除5例,Ⅳ级切除4例。术后患者均每6个月进行随访,影像学提示未见肿瘤复发。结论:准确全面的术前评估、正确的手术方法、积极的术后治疗是提高蝶骨嵴脑膜瘤全切率、改善神经症状、减少术后并发症的关键。     

陶寺ⅡM22漆杆与圭表测影

通过计算分析,推测《周髀算经》中的冬夏至影长可能是陶寺文化时期在山西襄汾陶寺遗址观测得到的。2002年,在陶寺遗址中期城址的王墓IIM22中出土一根漆杆,经过对该漆杆进行复原,并进行计算与模拟观测,得出漆杆上的粉色环带所对应的日期与陶寺观象台日出狭缝所对应的日期基本一致。根据计算推测出残损的漆杆全长应为173厘米左右,通过翻杆进行测量,是当时测影所用的圭尺。     

Determination of active ingredients in hawthorn and hawthorn piece by capillary electrophoresis with electrochemical detection

Capillary-zone electrophoresis with electrochemical detection has been used for the separation and determination of (-)-epicatechin, rutin, hyperin, chlorogenic acid, and quercetin in hawthorn and hawthorn piece. The effects of several important factors, including the running buffer acidity, the separation voltage, and the working electrode potential, were evaluated to acquire the optimum analytical conditions. The working electrode was a 300-μm carbon-disk electrode at a working potential of +0.95 V (vs. SCE). Under the optimum conditions, the analytes can be well separated within 16 min in a 75-cm-long fused-silica capillary. The current response was linear over two orders of magnitude with detection limits (S/N = 3) ranging from 6.00 × 10⁻⁸ to 3.75 × 10⁻⁷ g/mL for all analytes. The method was successfully used in the analysis of hawthorn and hawthorn piece and the assay results were satisfactory. The text was submitted by the authors in English.     

函数τT,L为弱T—函数的充要条件

部分解决了文献［１］中提出一个公开问题，通过相应地减弱Ｔ与Ｌ的条件并结合Ｔ与Ｌ，得到了τＴ，Ｌ成为弱Ｔ－函数的充要条件。     

Modeling of particle‐dispersed melting mechanism and its application in corotating twin‐screw extrusion

Particle‐dispersed melting is a complex but important melting mechanism in the corotating twin‐screw extruder. In this study, the complex multi‐particle‐dispersed system was simplified into a single‐particle melting model. The finite‐difference method was introduced to solve this problem. The simulation results show that the melting of a particle may involve two steps: the heating stage and melting stage. The heating time and melting time depend on solid concentration, initial melt and solid temperature, and shear rate. Calculations indicate that high solid concentration and solid temperature, low melt temperature and shear rate will result in a more uniform temperature distribution after polymer melting. The model offers valuable information for designing the melting zone in a corotating twin‐screw extruder, especially at high screw speed. © 2001 John Wiley & Sons, Inc. J Polym Sci Part B: Polym Phys 39: 2461–2468, 2001