Toward the most versatile fluorophore: Direct functionalization of BODIPY dyes via regioselective C—H bond activation

BODIPY dyes are privileged fluorophores that are now widely used in highly diverse research fields. An overview of BODIPY dyes and a summarization of the different synthetic methodologies reported for direct C-H functionalization of the BODIPY framework have been provided.     

Sensitive high-performance liquid chromatography/mass spectrometry method for determination of steviol in rat plasma

The main toxicological concern of stevioside, a highly potent sweetener from S. rebaudiana, is its main metabolite, steviol. To determine very low levels of steviol in in vivo experiments, a sensitive liquid chromatography/atmospheric pressure chemical ionization mass spectrometry (LC/APCI-MS) method was developed for quantifying steviol in rat plasma after oral administration of a single dose of stevioside (0.5 g/kg). The sample preparation uses liquid-liquid extraction with tert-butyl methyl ether in an acidic environment. The retention time of steviol was 10.5 min. The assay was linear over the range 2-1000 ng/mL with a lower limit of detection of 1 ng/mL. The intra- and inter-day precision were <5 and <7%, respectively, and the accuracy was in the range 95-108%. The steviol concentration profile in rat plasma was determined.     

一种基于流动注射梯度技术识别异常峰及校正的方法

基于流动注射梯度信息提出了一种利用梯度比均值进行定量的校正方法。方法具有在线自动判别和修复异常峰并自行校正的功能，和通用的标准系列定量方法相比，两者测定精度相当。但本文提出的方法抗干扰能力明显优于后者，可适用于在线过程监测。     

Synthesis of Cyanobenzaldehydes （m—,o—,p—）by Molecular oxygen Oxidation Methods

Cyanobenzaldehydes (m-,o-,p-) were synthesized by oxidation of corresponding tolunitriles with molecular oxygen,catalyzed by cobalt acetate and sodium bromide.     

贫水电解质体系制备多孔阳极氧化铝模板的研究

在有机溶剂为主的含草酸电解质中,研究了大孔径有序度高的阳极氧化铝(AAO)的一步法电化学制备.实验证实,电解质中水含量的降低能够有效抑制铝的电氧化速率和溶解速率,使得其氧化膜孔道的生长能够稳定进行,所得到的六方孔道排列有序度明显高于纯水溶剂制备的电解质体系下的产物.考察了水含量、有机溶剂种类以及电解质浓度对AAO模板孔道形貌的影响.结果表明,有机溶剂贫水电解质体系使得电氧化电压的选取范围比水溶液电解质体系更宽,孔径连续可调,反应条件温和.该方法适合于制备均匀大孔径的AAO模板.     

面向化妆品产业升级的江南大学应用化学专业建设思考与实践

Based on the development prospect of cosmetics industry, the advantage of light industry characteristic and the foundation of applied chemistry in Jiangnan University, a systematic upgrading of applied chemistry was carried out through "emerging engineering education (3E)" project "upgrade and practice of chemistry-related majors of local and/or trade university responding to the social developments" supported by the Ministry of Education. On the basis of investigation and analysis, the orientation and training goal of applied chemistry were updated first, and then the curriculum system was determined and the curriculum construction is strengthened, so as to achieve more distinctive characteristics, more solid foundation and more comprehensive quality. In view of the new requirements of the 3E for talent training, some practices have been formed in the aspects of multi-disciplinary integration, multi-angle coordination and close integration to industry. Contributing the development of cosmetics industry and seizing the commanding point of science and technology from the perspective of talent training, will play a unique role in human social progress.     

杂环光化学——Ⅺ.1,3-二甲基-6-氮杂胸腺嘧啶和丙酮的光反应

研究了1,3-二甲基-6-氮杂胸腺嘧啶和丙酮的光反应。反应机理中包含有三线态激基复合物和由此相继形成的两个不同结构的双自由基作为反应中间体。最终得到了1:2的加成产物, 即2,2,4,4,6,8,10-七甲基-7,9-二氧代-3,5-二氧杂-1,8,10-三氧杂双环[4,4,0]癸烷(Ⅰ)。     

Encrypting Chemical Reactivity in Protein Sequences toward Information‐Coded Reactions†

Controlling chemical reactivity has been the central theme in chemistry. Herein, we review the recent progress on the development of genetically encoded protein coupling reactions and their potential applications. The chemical reactivity is encoded in the protein sequences. The information is read out by folding and molecular recognition between two reactive components and subsequently translated into chemical bonding via autocatalysis. It has emerged as a unique way to tune the chemical reactivity and is regarded as one type of information‐coded reactions. Not only has it received many applications such as protein topology engineering, bioconjugation, biomaterials and synthetic biology, but also its principle may be extended beyond protein chemistry to enable new modes of supramolecular interactions that promote chemical bonding and that are simultaneously reinforced by covalent bonds.