Keratinized epithelial transport of beta-blocking agents. I. Relationship between physicochemical properties of drugs and the flux across rat skin and hamster cheek pouch.

The maximum fluxes (Jmax) of beta-blockers through keratinized membranes were determined in vitro and compared with their physiochemical parameters such as lipophilicity (log k'0) and melting point (mp). Rat abdominal skin and hamster cheek pouch mucosa were used as the model membranes. Propranolol, metoprolol, timolol, pindolol, nadolol and agenolol were used as beta-blockers with a variety of physicochemical characters. Linear relations of Jmax with either log k'0 or mp were observed both in intact rat skin and in intact hamster cheek pouch, suggesting that the lipophilicity and thermodynamic activity of a drug in the crystal state primarily affect the drug's permeation through these membranes. However, the slope, dJmax/d(log k'0), for cheek pouch mucosa was greater than that for rat skin, corresponding to the lack of appendigeal shunt pathways in cheek pouch. Penetration studies using the delipidized membranes and the isolated stratum corneum sheet of hamster cheek pouch mucosa clarified that the primary rate-limiting barrier function might exist in the lipid layer of the stratum corneum. Jmax values for the tape-stripped and delipidized skins correlated with both the solubilities of drugs in the vehicle and with the mp, suggesting the polar porous characteristics of both model membranes. However, a theoretical approach confirmed that the contribution of an intracellular or aqueous pore route in the intact membrane to the permeation of drugs with positive lipophilic indexes is negligible.     

钠-氨水体系对ω-酰基莰烯的还原反应研究

以钠-氨水体系为还原剂，苯为溶剂，对属于a，β-不饱和酮类的8个ω-酰基莰烯类化合物进行了还原．结果表明：足量钠作用下，还原产物为饱和醇(α-异莰烷基醇)，有内型与外型两种异构体；酰基部分的烃基越大，外型醇的比例越高．对所得的α-异莰烷基醇作了GC—MS分析，对还原过程与立体化学进行了讨论．     

A Comparative Study on Dynamic and Static Sparsity Patterns in Parallel Sparse Approximate Inverse Preconditioning

Sparse approximate inverse (SAI) techniques have recently emerged as a new class of parallel preconditioning techniques for solving large sparse linear systems on high performance computers. The choice of the sparsity pattern of the SAI matrix is probably the most important step in constructing an SAI preconditioner. Both dynamic and static sparsity pattern selection approaches have been proposed by researchers. Through a few numerical experiments, we conduct a comparable study on the properties and performance of the SAI preconditioners using the different sparsity patterns for solving some sparse linear systems. This revised version was published online in July 2006 with corrections to the Cover Date.     

高剂量率单次快脉冲辐射参量测量

记述了“强光一号”高剂量率脉冲辐射装置在状态调试过程中对其出射波形和辐射剂量进行监测的基本情况，实际监测的结果与设计方监测的结果进行了比对，双方的剂量监测值基本一致，偏差在20％以内；双方的波形形状十分相似，但测量得到的波形半宽度却相差10～20ns，最后对双方束流监测产生的差异进行了定性分析。     

浅谈本科毕业设计(论文)质量的提高

分析了本科毕业设计(论文)工作的现状及普遍存在的问题,以南通大学为例,探讨了以本科教学水平评估为契机,切实提高毕业设计(论文)质量的方法。     

60keV质子辐照对TiNi记忆合金薄膜马氏体相变的影响

 利用磁控溅射的方法在氧化后的单晶Si基片上制备了TiNi形状记忆合金薄膜，利用示差扫描量热法和原位X射线衍射研究了薄膜的马氏体相变特征。通过60keV质子注入（辐照）薄膜样品研究了H+离子对合金薄膜马氏体相变特征的影响，结果表明氢离子注入后引起了马氏体相变开始Ms和结束点Mf以及逆马氏体相变开始As和结束温度Af的下降，而对R相变开始Rs和结束温度Rf影响不大。掠入射X射线衍射表明H+离子注入后有氢化物形成。H⁺离子注入形成的氢化物是引起相变点的变化的主要因素。     

广义向量均衡问题的解与解集的凸性

引进集值映射的锥真拟凹概念，讨论一类具有集值映射的广义向量衡问题解的存在性与解集的凸性。     

浅谈高校院系门户系统及其应用

介绍了高校院系门户系统的概念,分析了院系门户系统的结构,探讨了院系门户系统的实现和意义。     

农民收入与农村土地使用状况的相关性研究

基于对山东省农民收入与农村土地使用状况的调查,发现农民人均收入与人均耕地资源的占有呈负相关关系,并对其形成原因进行了剖析,对农民增收、实现农村现代化的策略进行了探讨。