凹甲陆龟的泌尿生殖系统

凹甲陆龟的肾扁平,左右肾形状大小不一,呈荷兰豆荚形或块状方形．有特殊折叠,折起的形成可能与消化系统发达、遗传发育等因素有关．泄殖腔内有明显的环褶将肛道与尿、生殖道分开．附睾长而大,可能与精子的发育成熟和繁殖习性有关．     

我国城市绿地系统的规划与建设

城市绿地系统作为城市自然系统的主体,发挥着重要的生态功能.我国城市绿地建设普遍滞后,现在的城市绿地系统规划还存在不少问题,本文在分析绿地功能的基础上指出了在我国城市绿地系统规划与建设中所存在的几个主要问题,粗略地点明了解决这些问题的几点对策,尝试构建了使我国城市绿地系统规划顺利进行的内外条件.     

甘肃省地质灾害发育特征

甘肃省地质环境条件复杂,受极端天气、地震及人类工程活动等影响,区内地质灾害多发、频发,防灾减灾形势严峻。为进一步查清甘肃省地质灾害现状发育特征,在甘肃省1:5 万地质灾害风险调查最新数据分析的基础上,分析了全省地质灾害灾情险情特征、总结了地质灾害时空分布规律及致灾特征。研究结果表明：（1）甘肃省地质灾害以崩塌、滑坡、泥石流为主,灾害规模多为中小型;（2）在空间分布上,地质灾害主要集中分布于甘肃省中部和东南部的9 个市州,属于黄河流域及黄土高原区、白龙江流域及陇南山地;（3）在时间分布上,5-9 月主汛期是地质灾害高发期,以7 月下旬至8 月上旬最为严重;（4）地质灾害具群发致灾、隐蔽致灾和链式致灾特征。研究成果可为区域地质灾害风险管控和应急管理提供一定的技术依据和参考。     

FM信号单音干扰效果评估方法

FM信号受单音干扰时,有时无法获取干扰信号信息,但易获取输入信号和输出信号信息。提出将均方误差公式进行改进,并与干信比这一指标相关联,间接对FM信号进行单音干扰效果评估的方法。首先,建立了FM信号仿真模型,分析了不同信噪比下FM解调信号的波形失真情况;其次,分析了FM调制信号受到单音干扰时,在不同干信比下FM解调信号的波形失真情况;然后,用均方误差公式来表示模拟信号失真度,分析其与干信比的变化曲线,并对均方误差公式进行改进,仿真研究后得到新的评估指标;最后,分析了新评估指标与干信比和占空比的关系。     

常态中子深度分析物理模型

带电离子在样品内输运过程中的能量岐离、探测立体角有效范围及探测系统噪声都将改变中子深度分析（NDP）的多道离子能谱分布。假定上述三种因素导致的离子探测谱能量展宽都可以采用高斯函数描述,基于一般条件下的NDP装置设计,建立了预测一定深度核素产生的离子测量谱的探测器响应函数物理模型。该模型的理论分析结果与实验测量能谱的峰位、半高宽均符合良好,能够作为中子深度分析测量谱反演分析的基础。     

Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection

Cepharanthine (CEP) has excellent anti-SARS-CoV-2 properties, indicating its favorable potential for COVID-19 treatment. However, its application is challenged by its poor dissolubility and oral bioavailability. The present study aimed to improve the bioavailability of CEP by optimizing its solubility and through a pulmonary delivery method, which improved its bioavailability by five times when compared to that through the oral delivery method (68.07% vs. 13.15%). An ultra-performance liquid chromatography tandem-mass spectrometry (UPLC-MS/MS) method for quantification of CEP in rat plasma was developed and validated to support the bioavailability and pharmacokinetic studies. In addition, pulmonary fibrosis was recognized as a sequela of COVID-19 infection, warranting further evaluation of the therapeutic potential of CEP on a rat lung fibrosis model. The antifibrotic effect was assessed by analysis of lung index and histopathological examination, detection of transforming growth factor (TGF)-β1, interleukin-6 (IL-6), α-smooth muscle actin (α-SMA), and hydroxyproline level in serum or lung tissues. Our data demonstrated that CEP could significantly alleviate bleomycin (BLM)-induced collagen accumulation and inflammation, thereby exerting protective effects against pulmonary fibrosis. Our results provide evidence supporting the hypothesis that pulmonary delivery CEP may be a promising therapy for pulmonary fibrosis associated with COVID-19 infection.     

一类求解鞍点问题的广义不精确Uzawa方法

本文提出了一类求解大型稀疏鞍点问题的新的广义不精确Uzawa算法.该方法不仅可以包含 前人的方法, 而且可以拓展出很多新方法. 理论分析给出该方法收敛的条件, 并详细的分析了其收敛性质和参数矩阵的选取方法. 通过对有限元离散的Stokes问题的数值实验表明, 新方法是行之有效的, 其收敛速度明显优于原来的算法.     

Relative and Absolute Configuration of Vatiparol (1 mg): A Novel Anti‐inflammatory Polyphenol

Bioactive natural products offer multiple opportunities for the discovery of novel chemical entities with potential pharmaceutical, nutraceutical and agrochemical applications. Many new organic compounds with novel scaffolds are isolated in small quantities and established methods often fail to determine the structure and bioactivity of such novel natural products. To meet this challenge, we present here a new methodology combining RDC (residual dipolar coupling)‐based NMR spectroscopy in microtubes, with a motif‐inspired biological assessment strategy. Using only one milligram (ca. 1.5 μmol) of sample, the new protocol established the bioactivity as well as the relative and absolute configuration of vatiparol obtained from Vatica parvifolia. Vatiparol is unique in its unprecedented carbon skeleton and selective inhibitory effect on the expression of monocyte chemo‐attractant protein‐1 (MCP‐1, also known as CCL2). The plausible biosynthetic pathway of vatiparol is briefly discussed. The approach introduced here promises to be widely applicable to the determination of the structure and bioactivity of structurally unknown organic samples available in very limited amounts.     

Surface-enhanced resonant Raman spectroscopy (SERRS) of single-walled carbon nanotubes absorbed on the Ag-coated anodic aluminum oxide (AAO) surface

In this paper, we developed a new kind of substrate, the silver-coated anodic aluminum oxide (AAO), to investigate the characters of surface-enhanced resonant Raman scattering (SERRS) of the dilute single-walled carbon nanotubes. Homogeneous Ag-coated AAO substrate was obtained by decomposing the AgNO₃ on the surface of AAO. single-walled carbon nanotubes (SWNTs) were directly grown onto this substrate through floating catalyst chemical vapor deposition method (CVD). SERRS of SWNTs was carried out using several different wavelength lasers. The bands coming from metallic SWNTs were significantly enhanced. The two SERRS mechanisms, the “electromagnetic” and “chemical” mechanism, were mainly responsible for the experiment results.