Novel phototherapeutic agents： Investigation and progress of hypocrellin derivatives

Hypocrellins, as a kind of novel phototherapeutic agents, have several advantages over the clinically used hematoporphyrin derivatives, including high-excited triplet state yield, high phototoxicity, low dark toxicity, and rapid metabolism. However, they exhibit little absorption in the photodynamic window (600--900 nm) and are not water soluble, which limits their application in photodynamic therapy. Sulfonated and metal-ioned hypocrellins have been designed and synthesized to improve their water solubility.Unfortunately, the water-soluble derivatives obtained exhibit lower photodynamic activity than the parent hypocrellins.Thiolated and aminated hypocrellins have also been designed and synthesized to enlarge their photoresponse. Among them,the aminated hypocrellins possess the highest photodynamic activity. We recently have further designed and synthesized some amphiphilic aminated hypocrellin derivatives. Thus,not only the photoresponse but also the water solubility is enhanced. The experiments in vitro and in vivo on the derivatives are under way at present.     

基于平顺性的矿用人车悬架参数匹配研究

为解决矿用人车平顺性较差的问题,提出一种基于平顺性评价指标的悬架参数匹配方法。通过悬架系统非线性动力学模型,分析悬架刚度、阻尼、缓冲块刚度和间隙对平顺性的影响,以随机路面下1/3倍频带加权加速度均方根值和脉冲激励下车身最大加速度响应作为评价指标,兼顾悬架动载荷的标准差和动挠度,分别在随机输入下进行悬架刚度和阻尼匹配,在脉冲输入下进行缓冲块刚度和间隙匹配。通过改进前和改进后的对比试验,证明了合理匹配后的悬架能够很大程度降低车身加权加速度值,改善车辆在随机路面和脉冲激励下的行驶平顺性。     

结合低秩分解与多流融合的行为识别方法

运动信息对行为识别任务至关重要。现有方法仅利用了局部运动信息,忽略了全局运动信息的重要作用。为解决该问题,提出了一种基于低秩分解与多流融合的行为识别方法。通过3条支路分别提取视频的特征,第1条支路利用低秩分解提取全局运动信息;第2条支路提取视频的光流特征以得到局部运动信息;第3条支路利用原始视频作为输入,以保留完整的空域信息。将3条支路的预测结果进行后融合,得到最终的行为识别结果。通过多流融合,充分利用视频的多尺度时域运动信息和丰富的空域信息,提高现有模型的行为识别能力。实验结果表明,提出的方法优于现有模型的多流融合行为识别方法。     

Nanostructural evolution of Zn by dry roller vibration milling at room temperature

It remains open to date to produce stable nanostructures of single element by dry mechanical method at room temperature on a large scale. Here we report nanostructural evolution of zinc by dry roller vibration milling at room temperature, which leads to structurally near perfect zinc flakes sized 3?5 nm in diameter. The synthesized nanostructures are single crystalline, transparent, uniform, randomly oriented, almost equiaxed, and mostly free from defects. The evolution seems to open a way to optimize zinc nanostructures by the mechanical method, offer valuable references to prepare nanostructures of other metals optimally, and shed light on how to lower the size limit by mechanical milling. Single elemental metal nanostructures with excellent properties give rise to new opportunities in scientific research and development of nanotechnology.     

一个修正的Hooke-Jeeves方法 (运筹学与控制论)

本文考虑不用导数信息求解无约束优化问题的方法。对于求解无约束优化问题的带有离散步的标准Hooke-Jeeves方法,目标函数值有可能在其加速步中增大。本文修正了标准HJMDS的加速步,保证了目标函数值在修正的带离散步Hooke-Jeeves方法的加速步中不增。然后,采用修正的带离散步Hooke-Jeeves方法设计了一个新算法。数值试验结果表明,修正的带离散步Hooke-Jeeves方法与带离散步的标准Hooke-Jeeves方法相比,其函数值计算次数明显减少,因而本文给出的修正的带离散步Hooke-Jeeves方法比带离散步的标准Hooke-Jeeves方法更为有效。     

广义布尔函数的正规性

基于布尔函数的正规性,提出了广义正规Boolean函数的概念,给出了一些广义正规Boolean函数的构造方法,证明了广义正规Bent函数及其对偶函数所具有的一些独特性质.     

A generalized block-by-block method for the system of linear Volterra integral equations of the second kind

In this paper,we provide a generalized block-by-block method for constructing block-by-block systems to solve the system of linear Volterra integral equations of the second kind,and then deduce some of the special cases.Compared with the expansion method and He’s homotopy perturbation method,respectively,numerical examples are given to certify the effectiveness of the method.The results show that the block-by-block method is very effective,simple,and of high accuracy in solving the system of linear Volterra integral equations of the second kind.     

EDA技术在数字电子技术实验中的应用

在数字电子技术实验中引入先进的EDA技术是数字电子技术实验教学改革的发展方向。介绍了EDA技术的设计流程及其常用开发软件QuartusⅡ的特点,并利用QuartusⅡ 6.1设计工具通过具体实例阐述了EDA技术在数字电子技术实验中的应用,体现了EDA技术在数字电子技术实验中的重要地位和作用。