克林沙星酰胺衍生物的简易合成及其体内外生物活性

通过特色羧酸与克林沙星吡咯环氨基直接反应,得到19个未见文献报道的克林沙星酰胺衍生物,产物收率52.8%～97.5%.目标分子结构得到1H NMR,13C NMR,HR MS的确证.在琼脂扩散法初筛的基础上进行MIC活性验证,进而对活性较好的化合物开展急性毒性试验以及化合物稳定性实验,由此发现了抗菌活性更强、毒性更低、...     

Influence of polymer backbone branching on liquid crystal mesomorphous in nonequimolar complexes of poly(ethyleneimine) and dendritic amphiphiles

Two kinds of ionic self‐assembled complexes of linear or branched poly(ethyleneimine) (lPEI or bPEI) with Percec‐type dendrons [(3,4,5)16G1‐COOH] were prepared as lPEI‐(3,4,5)16G1‐x and bPEI‐(3,4,5)16G1‐x , where x is the mole ratio of the carboxyl groups of the dendritic amphiphile to the amino groups at the PEI chain. The crystal and mesomorphous structures and thermal properties of these complexes were investigated with X‐ray diffraction (XRD), Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), and polarized optical microscope (POM). Both the lPEI and bPEI complexes exhibited the same α_H crystal phase and similar lamellar mesomorphous phase, irrespective of the branching of the polymer backbone and the binding degree. The lPEI series complexes lPEI‐(3,4,5)16G1‐x , however, had more ordered lamellar stacking than that of the bPEI‐(3,4,5)16G1‐x complexes, so the thermotropic liquid crystal phase SmA was formed only in the lPEI‐(3,4,5)16G1‐x complexes beyond the melting point of the tail crystal of the dendritic amphiphile. No liquid crystalline phase was found from the bPEI‐(3,4,5)16G1‐x complexes. The results suggest that the branching of polymer backbone plays a key role to the formation of thermotropic liquid crystal in the polymer–dendritic amphiphile complex. The present finding is significant for the design of functional nanostructures based on the ionic complexation of polymers and amphiphiles. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011     

苯甲醛丙氨酸金属配合物中性载体水杨酸根离子电极的研究

首次研究了基于苯甲醛丙氨酸合钴(Ⅱ)金属配合物[Co(Ⅱ) BBAA]为中性载体的PVC膜电极。该电极对水杨酸根(Sal-)具有优良的电位响应性能和->选择性并呈现出反Hofmeister选择性行为,其选择性次序为Sal->ClO42->SO42-。在pH5.0的磷酸盐缓->NO2->Br->Cl->SO3SCN->I->NO3冲体系中,电极电位呈现近能斯特响应,线性响应范围为3.2×10-5～1.0×10-1mol L,斜率为-56.4mV dec(20℃),检测下限为9.0×10-6mol L。采用交流阻抗技术和紫外可见光谱技术研究了电极的响应机理,结果表明配合物中心金属原子的结构以及载体本身的结构与电极的响应行为之间有非常密切的构效关系。电极可用于药品分析。     

The art of two-dimensional soft nanomaterials

The discovery of graphene has triggered the explosive development of two-dimensional(2D) nanomaterials, including both inorganic and organic species. Benefiting from the simple elemental composition, inorganic 2D nanomaterials were the center research in the past decade, which has long shadowed the research of 2D organic(or soft) nanomaterials. Although many kinds of2D soft nanomaterials have been successfully prepared, a unified definition for them is still impossible due to the complicate and quite different chemical structures between each other and even relying on totally different techniques to distinguish them. Since our first review on 2D soft nanomaterials in 2015, this field has moved forward with big success. In this review, we will focus on the development of 2D soft nanomaterials after 2015. In order to deliver better overview of this field, new and comprehensive classification is used in this review: 2D aromatic molecules, graphene and graphene nanoribbons, graphyne and graphdiyne,BxCyNznanosheets, 2D polymers, 2D supramolecules, crystalline 2D assemblies, 2D covalent organic frameworks, 2D metalorganic frameworks, sandwich-like 2D porous polymers, 2D polymer nanosheets, etc. The focus of this review lies on synthetic strategies and the challenges of characterization, definition and fundamental understanding.     

直接测量自聚焦透镜折射率分布的新方法

在讨论测量自聚焦透镜折射率分布的现有方法的基础上 ,提出了一种直接测量自聚焦透镜折射率分布的新方法———横向干涉法 ,并重点在理论上对这种非破坏性测量的新方法进行了讨论 .     

城市土地闲置及耕种闲置地现象研究——以重庆北碚区为例

以北碚区为例,运用Quick Bird卫星遥感影像、叠置北碚区规划图等进行室内制图作业,结合室外考察、验证,统计出北碚区城市闲置地及耕种闲置地的分布、面积,并根据耕种闲置地的坡度、整洁度、受污染状况等,将其分为4种类型,分析耕种闲置地现象对城市带来的正负面影响以及城市土地闲置及耕种闲置地现象出现的原因,最后提出以收入方差代替GDP的政绩考核地位、扭转土地财政、分类管理耕种闲置地等对策.     

重庆市外墙节能措施应用因素分析

以重庆市为例,对建筑节能协会、房地产开发企业、施工单位等有关专家进行了问卷调查,了解了一些主要城市住宅建筑外墙节能措施在实际中的应用程度,并将工程造价、施工难度、后期维护、政策支持和客户接受意愿等5个因素对墙体节能措施应用的影响程度进行了统计分析,得出工程造价对墙体节能措施的应用起着决定性的作用;其次是政策支持力度.论文的研究为进一步推动墙体节能措施提供了很好的参考依据.     

晶体Cu和Ar弹性模量随压强和温度的变化关系

应用统计物理理论导出了弹性模量B(T,p)随压强p和温度T的变化关系式,并具体计算出Cu与Ar的弹性模量B(T,p).结果表明:压强较低时,Cu和Ar的弹性模量随压强的变化很小,然而当Cu和Ar的压强分别大于1012Pa和1011Pa时,B随p的增大而迅速增大,B随T的升高而减小.     

Interaction Between Mitoxantrone Metal Complex and Titan Yellow by Resonance Rayleigh Scattering Spectra and Its Analytical Application

In a pH 2.4 Britton-Robinson buffer medium,the anthracycline antibiotics mitoxantrone(MXT) could react with metal ions such as Pd(Ⅱ),Co(Ⅱ) and Cu(Ⅱ) to form 1:2(molar ratio) cationic chelates,which further reacted with the anionic dye titan yellow to form 1:2 ternary ion-association complexes by electrostatic interaction. As a result,the intensity of resonance Rayleigh scattering(RRS) was enhanced greatly. These RRS spectral characte-ristics of various metal ion systems were similar,and the maximum RRS wave...     

四川省及重庆市绣球属的分类研究(II)——属的特征、分种检索表及种的描述

首次对四川省及重庆市绣球属作了较详尽的分类研究,提供了形态特征和分种检索表,并对每种进行了简要描述,包括了每种的文献引证、与近缘种的区别特征、物候、分布、标本引证等内容.绣球属在四川省及重庆市有18种及4变种,可明确地划分为4个组.离瓣组(Sect.Petalanthae(Maxim.)Wei)由西南绣球(H.davidii)和绣球(H.macrophylla)组成;挂苦子组(Sect.Heteromallae(Rehd.)Wei)由圆锥绣球(H.paniculata)、白背绣球(H.hypoglauca)、陕西绣球(H.hypoglaucavar.giraldii)、松潘绣球(H.sungpanensis)、挂苦绣球(H.xanthoneura)、四川挂苦绣球(H.xanthoneuravar.setchenensis)、灰绒绣球(H.mandarinorum)、大果绣球(H.macrocarpa)、白绒绣球(H.mollis)及微绒绣球(H.heteromalla)组成;绣球组(Sect.Hydrangea)由马桑绣球(H.aspera)、腊莲绣球(H.strigosa)、柔毛绣球(H.villosa)、乐思绣球(H.rosthornii)、莼兰绣球(H.longipes)、锈毛绣球(H.longipesvar.fulvescens)和盘果绣球(H.discocarpa)组成;冠盖组(Sect.CalyptrantheMaxim.)由冠盖绣球(H.anomala)、粉背绣球(H.glaucophylla)及绢毛绣球(H.glaucophyllavar.sericea)组成.