基于Inception-BiLSTM和迁移学习的结构损伤识别

针对传统卷积神经网络（convolutional neural network,CNN）方法在时空特征提取存在不足,提出一种改进的Inception与双向长短期记忆（ bi-directional long short-term memory,BiLSTM）联合模型,以全面学习振动信号中的空间和时序信息。首先,构建具有多尺度感受野的Inception模块,自适应地提取不同尺度下的空间特征;其次,BiLSTM序列化处理时间特征,以深度挖掘时间相关性;最后,通过全局平均池化和Softmax分类器来实现钢框架结构的损伤识别。为评估该模型对噪声的鲁棒性,引入高斯白噪声作为干扰。此外,采用迁移学习策略来评估模型在不同强度激励和小样本下的泛化能力,确保适用于不同的损伤识别任务。结果表明,与传统的CNN方法相比,该模型在无噪声条件下及信噪比超过25dB时保持了100%的识别精度。该方法解决了土木工程应用中样本量不足和不同强度激励的实际挑战。通过微调预训练模型的参数,实现了在不同强度激励和小样本情况下的知识迁移与泛化,从而增强了模型的实际适用性。     

泰勒宁在动脉栓塞治疗子宫肌瘤术后腹痛控制中的疗效观察

探讨泰勒宁胶囊在子宫动脉栓塞(UAE)治疗子宫肌瘤术后腹痛控制中的临床疗效。动脉栓塞治疗子宫肌瘤46例,患者随机分成两组(n=23)。腹痛开始给药,A组口服泰勒宁胶囊1粒/次tid;B组用消炎痛肛栓100mg/粒,1粒/次tid。A组患者镇痛质量分数明显优于B组(P0.01),A组存在胃肠道反应;B组出汗较多两组均无呼吸抑制、低血压和心动过缓。泰勒宁胶囊对子宫动脉栓塞(UAE)治疗子宫肌瘤术后腹痛的控1制疗效确切,副作用小,术后恢复快。     

南昌滕王阁明清庾楼群汇考——江右史话批判之四

本文通过地毯式发掘、排比明、清江右省、府、州、县、厅<官志>省会水次漕仓原始档案,系统还原明、清两代五个半世纪间.南昌章江水次五十余县邸阁漕仓望江楼群密集汇聚历史原貌;率先揭举明景泰三年又嘉靖六年江右官宪挪移高安等县废仓直接改筑滕王阁之滕学建筑秘史;并深刻揭示汉晋邸阁隋唐转型运动虽降至明、清,仍不断重复其农业文明仓储文化遗传基因漕仓邸阁/名胜楼阁/会馆公寓等社会政治、经济、文化三重复合身份循环转换的生命轮回模式;全面辩证洪州滕王阁原生态邸阁历史文化圈自然、人文、经济地理学核心价值;穿透封建史学迷雾与江右史话泡沫,复原千古名楼滕王阁庐山真面目.     

Cytotoxic and NF-κB inhibitory sesquiterpene lactones from Piptocoma rufescens

Six new (1-6) and eight known germacranolide-type sesquiterpene lactones, along with several known phenylpropanol coumarates and methylated flavonoids, were isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. The new compounds were identified by analysis of their spectroscopic data, with the molecular structure of 3 being established by single-crystal X-ray diffraction. The absolute configurations of the sesquiterpene lactones isolated were determined from their CD and NOESY NMR spectra, together with the analysis of Mosher ester reactions. Bioassay screening results showed the majority of the sesquiterpene lactones isolated (1-13) to be highly cytotoxic toward the HT-29 human colon cancer cell line, with the most potent compound being 15-deoxygoyazensolide (10, IC(50), 0.26 μM). In addition, several of the sesquiterpene lactones exhibited NF-κB (p65) inhibitory activity.     

“古文运动”之称谓辩疑

北宋古文走向复兴的过程能否称之为“古文运动”，这个问题一直悬而未决。事实上，古文复兴的倡导者不仅有明确的目标，而且形成了组织，产生了很大的社会影响，因而是可以称之为“古文运动”的。学界之所以对此提出疑问，不外乎对“运动”一词的理解存在着先验性错误。     

A cytotoxic dimeric furanoheliangolide from Piptocoma rufescens

A new sesquiterpene lactone, rufescenolide C (1), the first furanoheliangolide dimer, was isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. Its structure was determined by interpretation of its spectroscopic data, with the absolute configuration being established by analysis of the CD spectrum. A plausible biogenesis of this dimer is proposed. This compound showed potent cytotoxicity with an IC₅₀ value of 150 nM, when tested against HT-29 human colon cancer cells.     

The effect of cation size (H+, Li+, Na+, and K+) on McLafferty-type rearrangement of even-electron ions in mass spectrometry

Protonation and alkali-metal cation adduction are the most important ionization processes in soft-ionization mass spectrometry.Studies on the fragmentation mechanism of protonated and alkali-metal-cationized compounds in tandem mass spectrometry are essential and helpful for structural analysis.In some cases,it was often observed that a compound attached by different alkali-metal cations(or proton)exhibits similar fragmentation patterns but the relative abundances of product ions are different.This difference was considered to derive from the different electrostatic interactions of alkali-metal cations(or the bonded effect of proton)with the analyte.The alkali-metal cation with a smaller ionic radius shows stronger electrostatic interaction with the molecule because of its higher charge density.In addition,the bonded effect of the proton is stronger than the electrostatic interaction of the alkali-metal cation.In the present study,which used McLafferty-type rearrangements of even-electron ions([M+Cat]+,Cat=H,Li,Na,K)as model reactions,the effect of cation size in mass spectrometric fragmentation reactions is highlighted.These considerations were also successfully applied to interpret the similar but distinct fragmentation behavior of proton and alkali-metal cation adducts of a synthetic compound(2-(acetamido(phenyl)methyl)-3-oxobutanoate)and a drug(entecavir).     

Comparison of performance characterization of asphalt mastic prepared by foamed and unfoamed asphalt binders

Journal of Thermal Analysis and Calorimetry - Applying foamed warm-mix asphalt in pavement has attracted great attention, but its effects on asphalt mastic are not clear. This research investigated...     

A novel imaging tool for hepatic portal system using phase contrast technique with hydrogen peroxide‐generated O2 gas

The objective of this study was to investigate the potential of hydrogen peroxide‐generated oxygen gas‐based phase contrast imaging (PCI) for visualizing mouse hepatic portal veins. The O₂ gas was made from the reaction between H₂O₂ and catalase. The gas production was imaged by PCI in real time. The H₂O₂ was injected into the enteric cavity of the lower sigmoid colon to produce O₂ in the submucosal venous plexus. The generated O₂ gas could be finally drained into hepatic portal veins. Absorption contrast imaging (ACI) and PCI of O₂‐filled portal veins were performed and compared. PCI offers high resolution and real‐time visualization of the O₂ gas production. Compared with O₂‐based ACI, O₂‐based PCI significantly enhanced the revealing of the portal vein in vivo. It is concluded that O₂‐based PCI is a novel and promising imaging modality for future studies of portal venous disorders in mice models.     

Nonlinear vibration isolation via an innovative active bionic variable stiffness adapter (ABVSA)

Nonlinear Dynamics - During the process of spacecraft launch, the extreme vibration environment is the major influence factor that induces the failure of the mission. Inspired by the smooth motions...