Recent Progress in Mass Spectrometry-based Metabolomics for Colorectal Cancer

Metabolomics, one of the latest omics technologies, is employed to reveal overall metabolic trajectories, identify disease causative mechanisms and provide information for preventive diagnosis and drug targeting. Cancer is a disease known to alter cellular metabolism and so metabolomics can play an important role in the early diagnosis of cancer and in the evaluation of medical interventions and treatments for cancer. Many metabolomics studies rely on high-sensitive and high-throughput mass spectrometry platforms. In recent years, various mass spectrometry(MS) methodologies have been developed and enriched the scope of metabolite detection, contributing to disease studies, such as diabetes, cancer, and depression. Colorectal cancer is the third most diagnosed cancer worldwide and its incidence ranked third in China. This review focuses on the mass spectrometry technologies in metabolomics and summarizes the progress of metabolomics research in colorectal cancer.     

基于Skype API的视频监控系统的设计与实现

近年来,视频监控系统在安全防范、信息获取、指挥调度等领域内获得越来越广泛的应用.本文提出了一种针对于诸如家庭、人员职守、设备状况等情况进行监控的实现方案,通过对Skype VoIP平台的API集成,在监控现场的微机上只需安装一个USB摄像头即可实现监控,该系统可支持远程用户对实时监控图像的观看,以及基于即时通信的监控端控制,具备了智能性、灵活性和可伸缩性.     

碳量子点/纳米金@碳纳米管修饰电极同时检测鸟嘌呤和腺嘌呤

制备了一种碳量子点(CQDs)/金纳米颗粒(AuNPs)@羟基化多壁碳纳米管(MWCNT-OHs)复合膜修饰电极用于鸟嘌呤(GA)和腺嘌呤(AE)的同时检测.与裸电极和其它修饰电极相比,复合膜修饰电极能显著提高GA和AE的氧化峰电流及峰电位差,能够对GA和AE同时高灵敏检测.研究了GA和AE在复合膜修饰电极上的电化学行为,结果表明,在0.2 mol/L PBS(pH 7.0)中,GA和AE的氧化峰电流与浓度分别在1～200 μmol/L和2～80μmol/L范围内呈良好的线性关系,检测限分别为0.9和1.8 μmol/L.将该修饰电极用于人体血清样品中GA和AE的同时电化学检测,加标回收率在90.4％～107.4％之间,证明了该修饰电极在生物样品分析领域的应用潜力.     

马面鲀鱼皮复制及润湿性研究

以具有防污功能的马面鲀皮为生物复制模板,采用铸膜方法对其微观形貌进行了大面积复制,并对复制表面的润湿性进行了分析研究。研究结果表明,复制的PDMS样品表面产生了与生物样品一致性较好的绒毛结构。该结构大大增加了表面的疏水性,将使海洋生物附着的难度大幅度增大,从而改善表面的污损释放性能。     

货币供应量序列结构变化的内生断点检定

对2000年1月至2012年5月流通中的货币、狭义货币、广义货币进行结构变化的内生断点检验。综合结构变化单、双断点检验的结果,发现两种实证检验的结果是基本一致的。内生断点频繁地发生于2009年第一季度,金融危机爆发后扩张型货币政策使得货币供应量出现向上的截距漂移。其他断点发生在2004年6月、2007午2月和2010年2月等,这些断点也与特定的货币政策下的重大离散事件相对应,重大离散事件对货币供应量产生持续影响。     

Geometric and Electronic Behavior of C60 on PTCDA Hydrogen Bonded Network

Self-assembled supramolecular networks are promising spacer layer for electronic decoupling from the metal substrate.However,the mechanism behind of how the intrinsic electronic structure of spacer layers affects the adsorbate is still unclear.Here a hydrogen bonded network composed of n-type semiconducting molecules 3,4,9,10-perylene-tetracarboxylic-dianhydride(PTCDA)is prepared under ultra-high vacuum to serve as a spacer layer for functional organics C60 on Au(111).The geometric and electronic information of C60 was investigated by scanning tunneling microscopy and scanning tunneling spectroscopy(STM/STS)at 5 K.Effective decoupling from the metal surface yields an energy gap of 3.67 eV for C602nd,merely considering the HOMO-LUMO peak separation.The broadening of resonance peaks in STS measurements however indicates unneglected interlayer interactions in this hetero-organic system.Moreover,we scrutinize the nucleation sites of C60 on PTCDA layer and attribute this to the decreased diffusion capability on a less dense molecular arrangement possessing inhomogeneous spatial distribution of unoccupied molecular orbitals.     

Two-dimensional Molecular Phase Transition of Alkylated-TDPB on Au(111) and Cu(111) Surfaces

The derivatives of aromatic cores bearing alkyl chains with different lengths are of potential interest in on-surface chemistry, and thus have been widely investigated both at liquid-solid interfaces and in vacuum. Here, we report on the structural evaluation of self-assembled 1,3,5-tri(4-dodecylphenyl)benzene(TDPB) molecules with increased molecular coverages on both Au(111) and Cu(111) surfaces. As observed on Au(111), rhombic and herringbone structures emerge successively depending on surface coverage. In the case of Cu(111), the same process of phase conversion is also observed, but with two distinct structures. In comparison, the self-assembled structures on Au(111) surface are packed more densely than that on Cu(111) surface under the same preparation conditions. This may fundamentally result from the higher adsorption energy of TDPB molecules on Cu(111), restricting their adjustment to optimize a thermodynamically favorable molecular packing.     

面向前向纠错的无线Mesh网多播差错控制协议

针对无线Mesh网现有媒体访问控制层协议进行多播时效率较低的问题,在分层信标驱动的无线Mesh网多播差错控制协议(Layer-BLBP)的基础上,提出了一种面向前向纠错的无线Mesh网多播差错控制协议———混合分层信标帧驱动协议(HLBLBP).该协议通过引入前向纠错技术和减少多播纠错时控制帧数量来降低重传次数,从而提高了用于数据传输的实际开销占整个多播过程的时间比例.仿真实验结果表明,新协议有效提高了多播网络的总体性能,提供的实际吞吐率比Layer-BLBP提高了25%以上.     

基于测年法的永安石林形成年代及发育演化过程研究

以永安石林地区地质、水文地质资料为背景,利用不平衡铀系法,对区内不同高程的钙华沉积物岩样进行年龄测定,确定了永安石林形成年代为中更新世以来,距今约50万年.结合区域地质构造历史及沙溪河谷地貌发育演化过程,认为:永安石林的形成始于早更新世;主要是因地壳间歇性抬升运动且大湖盆地开始处于剥蚀环境,石炭二叠纪碳酸盐岩的上覆岩层逐渐被风化剥蚀后形成.     

健康促进对学龄前儿童铅中毒预防和控制的研究进展

综述了国内外学龄前儿童铅中毒的危害和防治现状,针对目前健康教育对降低铅暴露有效性的研究结果并不理想,而且部分研究尚存在设计缺陷的情形,提出了健康促进对学龄前儿童预防和控制铅中毒的必要性和科学根据。