Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

美国室内设计师资质考试及其对我国的启示

介绍了美国国家室内设计师资格委员会（NCIDQ）关于专业室内设计师的概念，以及NCIDQ室内设计师资质考试的方式及类型，并从室内设计观、室内设计教育等方面分析了这一考试对我国的启示作用，指出室内设计师资质考试制度是公众利益的重要保障，是规范室内设计行业的必要措施．     

历史现实幻象虚构生态理想——从《暴风雨》管窥莎士比亚的生态诗学思想

近年来新崛起的生态批评,从自然的视角为莎士比亚戏剧的研究提供了一个全新的途径.鉴于《暴风雨》在莎剧中的地位,从它来探讨莎士比亚在该剧中描绘的当时英国社会历史现实、虚构的幻象图景及作者内心展示的生态诗学思想具有很强的代表性.莎士比亚在该剧中完美地展现了文艺复兴时期人文主义者对自然人相互矛盾的态度:自然人需要人类文明的教化;人类文明卑劣地腐蚀了自然人.     

基于自适应预测滤波理论的模数转换器设计方法

基于自适应差分量化理论，提出了在不增加转换位数的情况下提高模数转换器(ADC)动态范围的一种设计方法。该方法通过量化输入与预测的差值来获得预测增益，从而扩大ADC的动态范围；通过差分量化值与预测值相加得到输出信号，并将该分别采用LMS和RLS算法进行处理．得到输入信号的预测值．计算机模拟结果证实，上述两种算法均能使模数转换器的动态范围提高约25dB．比较而言，RLS算法收敛速度更快，收敛性更好，但计算量较大．     

Orlicz-Sobolev空间的中点局部一致凸性

本文研究了Orlicz-Sobolev空间的中点局部一致凸性，通过结合Orlicz空间和Sobolev空间的技巧得到分别赋Luxemburg范数和赋Orlicz范数的Orlicz-Sobolev空间具有中点局部一致凸性的充要条件．     

BOUNDEDNESS OF MAXIMAL SINGULAR INTEGRALS

The authors study the singular integrals under the Hormander condition and the measure not satisfying the doubling condition. At first, if the corresponding singular integral is bounded from L2 to itself, it is proved that the maximal singular integral is bounded from L∞to RBMO except that it is infinite μ-a.e. on Rd. A sufficient condition and a necessary condition such that the maximal singular integral is bounded from L2 to itself are also obtained. There is a small gap between the two conditions.     

Approaches to improving critical current density of YBCO superconducting thick films deposited by electrophoresis

The irreversibility field (Hirr) of Y-based superconductor is much higher than that of Bi-based superconductor. Y-based superconductor is capable of maintaining stable electrical currents in high magnetic field and electric field, so it is a better suited mate-rial for electric-current applications. Commonly, the Y-based tapes comprise a YBCO thick film deposited on a flexible substrate, typically with an intermediate buffer layer, and an overcoat of noble metal. In this process, the interm…     

广义Sierpinski集

本文考察了包括平面上的各种广义 Cantor集 ,Sierpinski集和包括某些连续不可微曲线在内的广义 Sierpinski集 .由相似变换 ,导出了它们的级数表达式 ,并利用它和字符串空间的对应关系 ,计算出它们的Hausdorff维数     

束晕-混沌的复杂性理论与控制方法及其应用前景

本文系统论述涉及强流加速器等强流离子束装置中产生的束晕-混沌的复杂性理论与控制方法及其应用前景。强流离子束在核材料生产与增殖、洁净核能、放射性废物嬗变、放射性药物生产、重离子聚变、高能物理、核科学与工程、国防与民用工业和医疗等许多方面都有极其重要的应用潜力和诱人的发展前景。尤其是，近年来强流加速器驱动的放射性洁净核能系统是国内外关注的热门课题，因为它比常规核电更安全、更干净、更便宜。但是，强流离子束形成的束晕-混沌的复杂性现象已引起了国内外广泛关注，需要加以抑制、控制和消除这类现象，解决这一难题已经成为强流离子束应用中的关键问题之一。目前不仅必须深入研究这类束晕-混沌的复杂特性及其产生的物理机制，而且需要研究如何实现对束晕-混沌的有效控制，并寻求和发展其新理论、新方法和新技术。这就向强流离子束物理和非线性-复杂性科学及其技术提出了一系列极富挑战性的新课题。本文结合国内外的研究概况，根据我们多年来的研究成果，特别是我们首创性地提出了一些束晕-混沌的有效控制方法，它们包括：非线性反馈控制法，小波反馈控制法，变结构控制法，延迟反馈控制法，参数自适应控制法等，进行重点的介绍。对上述课题当前的主要进展及相关问题进行系统的总结和比较全面综述的评论。最后，指出该领域今后的研究方向，以推动这个崭新领域的深入研究和应用发展。