Comparative pharmacokinetic study of four major bioactive components after oral administration of Zhi‐Zi‐Hou‐Po decoction in normal and corticosterone‐induced depressive rats

A highly selective and efficient LC–MS/MS method was developed to determine the plasma concentration of magnolol, hesperidin, neohesperidin and geniposide following oral administration of Zhi‐Zi‐Hou‐Po decoction in normal and depressed rats. Plasma samples were pretreated by protein precipitation with methanol. Chromatographic separation was performed on an XTerra^® MS C₁₈ column using a gradient elution with a mobile phase composed of acetonitrile–0.1% aqueous formic acid. The proposed method was validated to be specific, accurate and precise for the analytes determination in plasma samples. The calibration curves displayed good linearity over definite concentration ranges for the analytes. The intra‐ and inter‐day precision of the proposed method at three different levels were all within <11.13% and the relative errors ranged from ?8.46 to 8.93%. The recovery of the four compounds ranged from 82.72 to 89.08% and no apparent matrix effect was observed during sample analysis. After full validation, the established method was successfully applied for comparing the pharmacokinetics of four components between normal and depressed rats. The results showed that the AUC and C_max of four analytes in depressed rats were significantly different from those in normal rats and might provide helpful information to guide the clinical use of Zhi‐Zi‐Hou‐Po to treat depression.     

有氧运动对肥胖大学生身体形态、身体成分相关指标的影响

本文研究有氧运动对身体形态、身体成分的影响,以期为控制体重和运动减肥提供数据支持。有氧运动能消耗人体大量的能量,在改变身体形态的基础上改善身体机能。中等强度的有氧运动对研究对象控制体重和减肥有显著效果。     

一类带非线性边界条件的非经典扩散方程解的爆破

In this article,under suitable conditions on the internal term f(·)and the bound-ary nonlinear term g(·),we prove blow-up results for a class of nonclassical diffusion equations with nonlinear boundary condition.     

非线性光机械系统中的弱力探测

从理论上研究了包含光学参量放大器的非线性腔光机械系统的弱力探测性能.一方面,发现通过调节光学参量放大器的非线性增益以及输入光场与腔场之间的有效失谐,可以减小压缩正交中约14 dB的量子噪声,从而将弱力探测灵敏度提高2倍以上.另一方面,分析了非线性腔结合零差测量产生的反作用噪声相消现象并且实现量子非破坏测量的方法.     

Experimental and numerical study of shock wave propagation in water generated by pulsed arc electrohydraulic discharges

The objective of this study is to simulate the propagation of the shock wave in water due to an explosion. The study is part of a global research program on the development of an alternative stimulation technique to conventional hydraulic fracturing in tight gas reservoirs aimed at inducing a distributed state of microcracking of rocks instead of localized fracture. We consider the possibility of increasing the permeability of rocks with dynamic blasts. The blast is a shock wave generated in water by pulsed arc electrohydraulic discharges. The amplitude of these shock waves is prescribed by the electrohydraulic discharges which generate high pressures of several kilobars within microseconds. A simplified method has been used to simulate the injected electrical energy as augmentation of enthalpy in water locally. The finite element code EUROPLEXUS is used to perform fluid fast dynamic computation. The predicted pressure is consistent with the experimental results. In addition, shock wave propagation characteristics predicted with simulation can be valuable reference for design of underwater structural elements and engineering of underwater explosion.     

Recent Advances for Selective Catalysis in Benzene Methylation: Reactions,Shape-Selectivity and Perspectives

Catalysis Surveys from Asia - Benzene methylation over zeolite offers an alternative route to produce high-value toluene or para-xylene directly from benzene and C1 chemical sources, especially for...