Electrochemical study of bergenin on a poly(4-(2-pyridylazo)-resorcinol) modified glassy carbon electrode and its determination in tablets and urine

A very sensitive electroanalytical method was employed to determine bergenin in phosphate buffer with a pH of 6.0, bergenin was accumulated at a 4-(2-pyridylazo)-resorcinol (PAR) polymer film modified glassy carbon electrode (GCE) surface under the condition of open-circuit. In the following anodic sweep from −0.4 to 0.8 V, bergenin adsorbed at the PAR polymer film modified electrode surface, was oxidized and yielded a sensitive oxidation peak at 0.595 V. Due to its unique structure and extraordinary properties, the PAR polymer film shows higher accumulation efficiency toward bergenin compared with a bare GCE. Hence, the amount of bergenin at the PAR polymer film modified GCE surface increases significantly, and finally the oxidation peak current improves greatly. The experimental conditions, such as supporting electrolyte, pH value, accumulation time and scan rate, were optimized for the measurement of bergenin, and a sensitive electroanalytical method was proposed for bergenin determination. The oxidation peak current varies linearly with the concentration of bergenin over the range of 2.0 × 10⁻⁷ to 1.2 × 10⁻⁵ mol/L, and the detection limit is 2.0 × 10⁻⁸ mol/L after 3 min open-circuit accumulation. The relative standard deviation of the same electrode in 10 successive scans is 1.8% for 1.0 × 10⁻⁶ mol/L bergenin and 2.1% for interelectrodes, indicating excellent reproducibility. This new method was successfully demonstrated with bergenin tablets and diluted urine.     

The Aggregation Kinetics of Colloidal Particles of Basic Yttrium Carbonate

Studyofthegrowthprocessofcolloidalparticlesofnonequilibriumandirreversibilityisanactiveareaofresearch.Therecognitionofcolloidalaggregatesasfractalobjectshasinspiredalargenumberofexperimentalandtheoreticalstudiesonthestructuralandkineticaspectsofaggregationprocesses"'.Morerecently,kineticsofhematiteaggregationbypolyacrylicacidhavebeenstudiedbyzhangandBume3.Theprimaryhematiteparticleswerequiteuniformandfairlyspherical.Inthispaper,wewillreportthesizeevolutionoffractalaggregatesofinitiallypolydis…     

Oxidation resistant germanium nanowires: bulk synthesis, long chain alkanethiol functionalization, and Langmuir-Blodgett assembly

A simple method is developed to synthesize gram quantities of uniform Ge nanowires (GeNWs) by chemical vapor deposition on preformed, monodispersed seed particles loaded onto a high surface area silica support. Various chemical functionalization schemes are investigated to passivate the GeNW surfaces using alkanethiols and alkyl Grignard reactions. The stability of functionalization against oxidation of germanium for various alkyl chain lengths is elucidated by X-ray photoelectron spectroscopy. Among all schemes tested, long chain alkanethiols (> or = C12) are found to impart the most stable GeNW passivation against oxidation upon extended exposure to ambient air. Further, the chemically functionalized oxidation-resistant nanowires are soluble in organic solvents and can be readily assembled into close-packed Langmuir-Blodgett films potentially useful for future high performance electronic devices.     

ATMP(氨基三甲叉膦酸)及其顺磁性Co(Ⅱ)配合物的核磁共振研究

本文用¹H、³¹P和¹³C核磁共振谱研究了ATMP(氨基三甲叉膦酸,以简式H₆L表示)及其顺磁性Co(Ⅱ)配合物。测定了不同C_co/C_ATMP摩尔比在不同pH值下的各向同性位移。定性地讨论顺磁性Co(Ⅱ)配合物在不同pH条件下的组成、电荷和空间构型变化对化学位移的影响。运用快速交换反应中化学位移与配合物浓度的关系,确定不同pH下的条件稳定常数。     

Design of a novel chip on glass package solution for CMOS image sensor device

This paper presents a chip-on-glass (COG) package solution for CMOS image sensors based on highly precise and reliable bumping and flip-chip bonding techniques. The package is fabricated using three core techniques, namely the damage-free image sensor bumping technique, the wafer form glass substrate patterned technique, and the damage-free flip-chip bonding technique. Since the proposed package concept is new, the effects of the package geometry and material properties on the package reliability are uncertain in the initial design stage. A three-dimensional nonlinear finite element model of the proposed CMOS image sensor package is created. In the simulations, the applied thermal load is cooled from 200 °C to ambient temperature (25 °C) to model the thermal deformation and warpage of the package during the practical ACF assembly cooling process. The design parameters influencing the reliability of the package, i.e. the material properties of the ACF, the thickness of the image chip and the thickness of the optical glass are investigated. Two control levels are specified for the chip, glass, and ACF factors and a 2³ factorial design is created to determine the appropriate combination of material properties and geometric size. It is found that the glass thickness and the ACF properties significantly affect the thermal deformation of the package, while the chip and glass factors, and the interaction between them, significantly affect the warpage. Regression models are developed to perform a series of surface response simulations. Using the developed statistical tests and regression models, suitable material selection criteria and geometric sizes can be specified to satisfy various reliability considerations in the initial design stage.     

Quality-of-service provisioning and efficient resource utilization in CDMA cellular communications

One of the major challenges in supporting multimedia services over Internet protocol (IP)-based code-division multiple-access (CDMA) wireless networks is the quality-of-service (QoS) provisioning with efficient resource utilization. Compared with the circuit-switched voice service in the second-generation CDMA systems (i.e., IS-95), heterogeneous multimedia applications in future IP-based CDMA networks require more complex QoS provisioning and more sophisticated management of the scarce radio resources. This paper provides an overview of the CDMA-related QoS provisioning techniques in the avenues of packet scheduling, power allocation, and network coordination, summarizes state-of-the-art research results, and identifies further research issues.     

A novel low-complexity power allocation algorithm based on the NOMA system in a low-speed environment

For future wireless communication systems, Power Domain Non-Orthogonal Multiple Access (PD-NOMA) using an advanced receiver has been considered as a promising radio access technology candidate. Power allocation plays an important role in the PD-NOMA system because it considerably affects the total throughput and Geometric Mean User Throughput (GMUT) performance. However, most existing studies have not completely accounted for the computational complexity of the power allocation process when the User Terminals (UTs) move in a slow fading channel environment. To resolve such problems, a power allocation method is proposed to considerably reduce the search space of a Full Search Power (FSP) allocation algorithm. The initial power reallocation coefficients will be set to start with former optimal values by the proposed Lemma before searching for optimal power reallocation coefficients based on total throughput performance. Step size and correction granularity will be adjusted within a much narrower power search range while invalid power combinations may be reasonably discarded during the search process. The simulation results show that the proposed power reallocation scheme can greatly reduce computational complexity while the total throughput and GMUT performance loss are not greater than 1.5% compared with the FSP algorithm.     

Canady Cold Helios Plasma Reduces Soft Tissue Sarcoma Viability by Inhibiting Proliferation,Disrupting Cell Cycle,and Inducing Apoptosis: A Preliminary Report

Soft tissue sarcomas (STS) are a rare and highly heterogeneous group of solid tumors, originating from various types of connective tissue. Complete removal of STS by surgery is challenging due to the anatomical location of the tumor, which results in tumor recurrence. Additionally, current polychemotherapeutic regimens are highly toxic with no rational survival benefit. Cold atmospheric plasma (CAP) is a novel technology that has demonstrated immense cancer therapeutic potential. Canady Cold Helios Plasma (CHCP) is a device that sprays CAP along the surgical margins to eradicate residual cancer cells after tumor resection. This preliminary study was conducted in vitro prior to in vivo testing in a humanitarian compassionate use case study and an FDA-approved phase 1 clinical trial (IDE G190165). In this study, the authors evaluate the efficacy of CHCP across multiple STS cell lines. CHCP treatment reduced the viability of four different STS cell lines (i.e., fibrosarcoma, synovial sarcoma, rhabdomyosarcoma, and liposarcoma) in a dose-dependent manner by inhibiting proliferation, disrupting cell cycle, and inducing apoptosis-like cell death.     

等电聚焦分离与18O稳定同位素标记联用的磷酸化蛋白质组学定量方法研究

磷酸化蛋白质组学定量分析,要对磷酸化修饰富集技术和定量技术进行研究。基于此,本研究采用18O稳定同位素标记技术对胰蛋白酶酶解肽段混合物进行标记,并对其标记时间和标记后胰蛋白酶的变性条件进行优化。结果表明:在pH=4～5的KH2PO4缓冲体系中,37℃,标记反应持续19～24h,除了C-端肽之外,几乎所有的肽段都可达到100%标记;采用TCEP可以有效地抑制16O-18O回标现象。建立了与18O标记技术兼容性良好的IPG-IEF技术对磷酸化肽段进行选择性富集,富集后共从HepG2细胞中鉴定到491个磷酸化位点、362个磷酸化肽段和356个磷酸化蛋白,表明IPG-IEF在大规模磷酸化肽段分离富集中是有效的;最后与高准确度高灵敏度高分辨率的LTQ-FTICR质谱仪联用,建立了基于18O-IPG-IEF-LTQ-FTICR的磷酸化蛋白质组定量技术。实验结果表明,该技术可以实现磷酸化肽段的有效定性和定量。本研究为磷酸化蛋白质组学定量研究提供了实用技术。     

基于海洋背景红外图像的仿真系统研究

简要介绍了一种简便的基于海洋背景的红外仿真系统的设计和组成,阐述了各个模块的功能以及模块之间的联系。在实际存储红外图像素材基础上,通过直接添加模板图像,接着通过后续的处理模块来实现较好的模拟海洋红外图像中的目标的目的。从最后的结果可以看到这是一个简便有效的仿真系统。