An unexpected all-metal aromatic tetranuclear silver cluster in human copper chaperone Atox1

Metal clusters, such as iron–sulfur clusters, play key roles in sustaining life and are intimately involved in the functions of metalloproteins. Herein we report the formation and crystal structure of a planar square tetranuclear silver cluster when silver ions were mixed with human copper chaperone Atox1. Quantum chemical studies reveal that two Ag 5s¹ electrons in the tetranuclear silver cluster fully occupy the one bonding molecular orbital, with the assumption that this Ag₄ cluster is Ag₄²⁺, leading to extensive electron delocalization over the planar square and significant stabilization. This bonding pattern of the tetranuclear silver cluster represents an aromatic all-metal structure that follows a 4n + 2 electron counting rule (n = 0). This is the first time an all-metal aromatic silver cluster was observed in a protein.

Metal clusters, such as iron–sulfur clusters, play key roles in sustaining life and are intimately involved in the functions of metalloproteins.     

Alpha-Beta Hybrid Quantum Associative Memory Using Hamming Distance

This work presents a quantum associative memory (Alpha-Beta HQAM) that uses the Hamming distance for pattern recovery. The proposal combines the Alpha-Beta associative memory, which reduces the dimensionality of patterns, with a quantum subroutine to calculate the Hamming distance in the recovery phase. Furthermore, patterns are initially stored in the memory as a quantum superposition in order to take advantage of its properties. Experiments testing the memory’s viability and performance were implemented using IBM’s Qiskit library.     

Packed-Fiber Solid Phase-Extraction Coupled with HPLC-MS/MS for Rapid Determination of Lipid Oxidative Damage Biomarker 8-Iso-Prostaglandin F2α in Urine

The 8-iso-prostaglandin F_2α (8-iso-PGF_2α) biomarker is used as the gold standard for tracing lipid oxidative stress in vivo. The analysis of urinary 8-iso-PGF_2α is challenging when dealing with trace amounts of 8-iso-PGF_2α and the complexity of urine matrixes. A packed-fiber solid-phase extraction (PFSPE)–coupled with HPLC-MS/MS–method, based on polystyrene (PS)-electrospun nanofibers, was developed for the specific determination of 8-iso-PGF_2α in urine and compared with other newly developed LC-MS/MS methods. The method, which simultaneously processed 12 samples within 5 min on a self-made semi-automatic array solid-phase extraction processor, was the first to introduce PS-electrospun nanofibers as an adsorbent for the extraction of 8-iso-PGF_2α and was successfully applied to real urine samples. After optimizing the PFSPE conditions, good linearity in the range of 0.05–5 ng/mL with R² > 0.9996 and a satisfactory limit of detection of 0.015 ng/mL were obtained, with good intraday and interday precision (RSD < 10%) and recoveries of 95.3–103.8%. This feasible method is expected to be used for the batch quantitative analysis of urinary 8-iso-PGF_2α.     

Facile Fabrication of 1-Methylimidazole/Cu Nanozyme with Enhanced Laccase Activity for Fast Degradation and Sensitive Detection of Phenol Compounds

Facile construction of functional nanomaterials with laccase-like activity is important in sustainable chemistry since laccase is featured as an efficient and promising catalyst especially for phenolic degradation but still has the challenges of high cost, low activity, poor stability and unsatisfied recyclability. In this paper, we report a simple method to synthesize nanozymes with enhanced laccase-like activity by the self-assembly of copper ions with various imidazole derivatives. In the case of 1-methylimidazole as the ligand, the as-synthesized nanozyme (denoted as Cu-MIM) has the highest yield and best activity among the nanozymes prepared. Compared to laccase, the K_m of Cu-MIM nanozyme to phenol is much lower, and the v_max is 6.8 times higher. In addition, Cu-MIM maintains excellent stability in a variety of harsh environments, such as high pH, high temperature, high salt concentration, organic solvents and long-term storage. Based on the Cu-MIM nanozyme, we established a method for quantitatively detecting phenol concentration through a smartphone, which is believed to have important applications in environmental protection, pollutant detection and other fields.     

Genetically engineered materials: Proteins and beyond

Information-rich molecules provide opportunities for evolution. Genetically engineered materials are superior in that their properties are coded within genetic sequences and could be fine-tuned. In this review, we elaborate the concept of genetically engineered materials(GEMs) using examples ranging from engineered protein materials to engineered living materials. Proteinbased materials are the materials of choice by nature. Recent progress in protein engineering has led to opportunities to tune...     

短沟道MOSFET阈值电压辐照增强漂移效应

本文对γ辐照环境下,小尺寸MOSFET的性能进行了研究,发现了短沟MOSFET阈值电压辐照增强漂移效应;提出了辐照损伤电荷非均匀分布概念;开发了二维数值模拟程序,对辐照损伤电荷引起的器件物理作用进行了分析;建立了辐照环境下短沟道MOSFET的简化模型,成功地解释了实验现象;在理论分析的基础上,提出了适用于VLSI的抗核加固措施,并经实验证实其有效性。     

利用偏光分束棱镜测定波片的延迟量

在文〔３〕的基础上,提出了波片延迟量测量精度较高的方法。     

Progressive Linear Precoder Optimization for MIMO Packet Retransmissions Exploiting Channel Covariance Information

This work investigates the design of linear precoders for ARQ packet retransmissions in multi-input multi-output (MIMO) systems. We consider transmitter precoder design based on partial MIMO channel information in the form of their covariance feedback. Our objective is to maximize the ergodic mutual information provided by multiple (re)transmissions of a packet subject to transmission power constraint. We propose a set of near-optimal successive linear ARQ precoders for flat fading MIMO channels. This progressive linear ARQ precoder combines the appropriate power loading and the reverse-order pairing of singular values in the current retransmission with previous transmissions. This reverse-order pairing is a special feature unique to our sequential ARQ preceding approach with demonstrated performance gains.     

Stochastic iterative algorithms for signal set design for Gaussianchannels and optimality of the L2 signal set

We propose a stochastic iteration approach to signal set design. Four practical stochastic iterative algorithms are proposed with respect to equal and average energy constraints and sequential and batch modes. By simulation, a new optimal signal set, the L2 signal set (consisting of a regular simplex set of three signals and some zero signals), is found under the strong simplex conjecture (SSC) condition (equal a priori probability and average energy constraint) at low signal-to-noise ratios (SNR). The optimality of the L1 signal set, the confirmation of the weak simplex conjecture, and two of Dunbridge's (1967) theorems are some of the results obtained by simulations. The influence of SNR and a priori probabilities on the signal sets is also investigated via simulation. As an application to practical communication system design, the signal sets of eight two-dimensional (2-D) signals are studied by simulation under the SSC condition. Two signal sets better than 8-PSK are found. Optimal properties of the L2 signal set are analyzed under the SSC condition at low SNRs. The L2 signal set is proved to be uniquely optimal in 2-D space. The class of signal sets S(M, K) (consisting of a regular simplex set of K signals and M-K zero signals) is analyzed. It is shown that any of the signal sets S(M, K) for 3⩽K⩽M-1 disproves the strong simplex conjecture for M⩾4, and if M⩾7, S(M, 2) (the L1 signal set) also disproves the strong simplex conjecture. It is proved that the L2 signal set is the unique optimal signal set in the class of signal sets S(M, K) for all M⩾4. Several results obtained by Steiner (see ibid., vol.40, no.5, p.721-31, 1994) for all M⩾7 are extended to all M⩾4. Finally, we show that for M⩾7, there exists an integer K'相似文献