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981.
本文报道了作者提出的阶梯AlGaN外延层新型AlGaN/GaN HEMTs结构的实验结果. 实验利用感应耦合等离子体刻蚀(ICP)刻蚀栅边缘的AlGaN外延层, 形成阶梯的AlGaN 外延层结构, 获得浓度分区的沟道2DEG, 使得阶梯AlGaN外延层边缘出现新的电场峰, 有效降低栅边缘的高峰电场, 从而优化了AlGaN/GaN HEMTs器件的表面电场分布. 实验获得了阈值电压-1.5 V的新型AlGaN/GaN HEMTs器件. 经过测试, 同样面积的器件击穿电压从传统结构的67 V提高到新结构的106 V, 提高了58%左右; 脉冲测试下电流崩塌量也比传统结构减少了30%左右, 电流崩塌效应得到了一定的缓解. 相似文献
982.
Nan Deng Guijie Zhu Yuanbo Chen Qi Wu Zhen Liang Zhigang Sui Lihua Zhang Kaiguang Yang Yukui Zhang 《Analytica chimica acta》2014
A novel protein sample pretreatment method based on ampholine immobilized polymer microsphere (ampholine@PM) was developed for the fractionation of intact proteins prior to protein digestion and peptide analysis to reduce the dynamic range of human plasma proteome. After incubation with our prepared ampholine@PM, the captured plasma proteins were successively desorbed by 2 M NaCl, 100 mM glycine-hydrochloric acid, and 30% (v/v) acetonitrile with 0.1% (v/v) trifluoroacetic acid. The SDS-PAGE results showed the protein dynamic range in such three fractions was obviously reduced as compared with the native plasma. On-particle digestion was ultimately performed to release all proteins retained on ampholine@PM. Followed by MuPIT analysis, the number of identified proteins in plasma was improved by 75% after ampholine@PM treatment. Furthermore, the spectral count of 9 high abundance proteins was decreased by 37.6–97.2%, and the identified low abundance protein (<100 ng mL−1) number was increased from 4 to 17. These results demonstrated that the fractionation by ampholine@PM could efficiently decrease the protein dynamic range in abundance, beneficial to achieve the deep coverage identification of human plasma proteome. 相似文献
983.
A simple and sensitive method to determine Hg2+ was developed by combining solution-cathode glow discharge atomic emission spectrometry (SCGD-AES) with flow injection (FI) based on on-line solid-phase extraction (SPE). We synthesized l-cysteine-modified mesoporous silica and packed it in an SPE microcolumn, which was experimentally determined to possess a good mercury adsorption capacity. An enrichment factor of 42 was achieved under optimized Hg2+ elution conditions, namely, an FI flow rate of 2.0 mL min−1 and an eluent comprised of 10% thiourea in 0.2 mol L−1 HNO3. The detection limit of FI–SCGD-AES was determined to be 0.75 μg L−1, and the precision of the 11 replicate Hg2+ measurements was 0.86% at a concentration of 100 μg L−1. The proposed method was validated by determining Hg2+ in certified reference materials such as human hair (GBW09101b) and stream sediment (GBW07310). 相似文献
984.
Shanshan Tong Min Fu Xia Cao Caleb Kesse Firempong Chengxue Yi Qianfeng Zhen Hui Zhong Jiangnan Yu Ximing Xu 《Chromatographia》2014,77(5-6):419-429
For the first time, a novel biological affinity separating system called lipid raft stationary phase chromatography (LRSC) was developed. It was employed to screen bioactive components from Chinese gallnut, a traditional Chinese medicine (TCM). The LRSC was prepared by the addition of activated silica to Tris–HCl solution, which contains the isolated lipid rafts of U251 cells. This was followed by agitation, washing, centrifugation and then re-suspension of the residue in another Tris–HCl solution. The lipid rafts possess abundant receptor tyrosine kinase, specifically tropomyosin-related kinase A (TrkA), which is a widely researched anti-tumor drug target. Thus, TrkA provided the LRSC model with the ability to select fractions that specifically interact with it. Using a non-TrkA targeted anti-tumor drug (gemcitabine) and TrkA targeted anti-tumor drugs (lestaurtinib and gefitinib) as controls to evaluate the specific affinity of the LRSC column, the different fractions of Chinese gallnut were subjected to LRSC screening for the identification of anti-tumor components. As a result, the ether fraction of Chinese gallnut manifested desirable affinity properties. The methyl thiazolyl tetrazolium assay confirmed the anti-tumor effect of the screened ether fraction, and more importantly, the ether fraction failed woefully to exhibit its anti-proliferative activity in the presence of TrkA inhibitors (K252a and primary antibody). This further proves the selectivity of LRSC on TrkA-targeted drugs. The LRSC model has, therefore, shown to be of high efficiency and selectivity in screening bioactive components from the complex TCM extracts, thus offering an effective approach for the development of anticancer natural products. 相似文献
985.
A New Cyclic Peptide and a New Steroid from the Fungus Penicillium sp. GD6 Isolated from the Mangrove Bruguiera gymnorrhiza 下载免费PDF全文
Zhen‐Fang Zhou Xiao‐Hong Yang Hai‐Li Liu Yu‐Cheng Gu Bo‐Ping Ye Yue‐Wei Guo 《Helvetica chimica acta》2014,97(11):1564-1570
A rare new cyclic tetrapeptide, 5,5′‐epoxy‐MKN‐349A ( 1 ), featured by a MKN‐349A ( 5 ) skeleton and containing an uncommon ether bridge between C(5) and C(5′), and a new steroid, named 11‐O‐acetyl‐NGA0187 ( 2 ), together with two known steroids, 3 and 4 , were isolated from an endophytic fungus Penicillium sp. GD6 associated with the Chinese mangrove Bruguiera gymnorrhiza. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analyses and by comparison with the data of related compounds reported in literature. Neither of the compounds 3 and 4 , isolated in this study, showed obvious bioactivities in the antibacterial bioassay experiments. 相似文献
986.
Tandem Aza‐Michael–Aldol Reactions: One‐Pot Synthesis of Functionalized Piperidine Derivatives 下载免费PDF全文
Fu‐Ping Huang Zhen‐Wen Dong Hai‐Rui Zhang Xin‐Ping Hui 《Journal of heterocyclic chemistry》2014,51(2):532-538
A series of novel functionalized piperidine derivatives were conveniently prepared by three‐component tandem aza‐Michael–Aldol reactions of α,β‐unsaturated enones with substituted sulfonamides in the presence of DBU. The structures of the compounds synthesized were characterized by spectral data and X‐ray crystal diffraction. 相似文献
987.
提出一个基于极限学习机ELM(Extreme Learning Machine)和文化基因算法MA(Memetic Algorithm)的微型四频(0.92/2.4/3.5/5.8GHz)天线设计算法AntMA-ELM.为了提高天线的性能,算法在MA框架下引入基于综合学习粒子群优化算法CLPSO(Comprehensive Learning Particle Swarm Optimizer)全局搜索和DSCG(Davies,Swann,and Campey with Gram-schmidt)局部搜索,用于确定天线的几何参数.同时,建立ELM回归模型用于直接评估MA优化的适应值函数.实验结果表明,ELM回归模型能够根据输入参数正确估算天线的回波损耗,使MA算法有效提高设计性能和加速优化过程.天线在四个目标频段的回波损耗值均优于-10dB,满足设计要求. 相似文献
988.
989.
990.
Blake N. Johnson Karen Z. Lancaster Gehua Zhen Junyun He Maneesh K. Gupta Yong Lin Kong Esteban A. Engel Kellin D. Krick Alex Ju Fanben Meng Lynn W. Enquist Xiaofeng Jia Michael C. McAlpine 《Advanced functional materials》2015,25(39):6205-6217
A 3D printing methodology for the design, optimization, and fabrication of a custom nerve repair technology for the regeneration of complex peripheral nerve injuries containing bifurcating sensory and motor nerve pathways is introduced. The custom scaffolds are deterministically fabricated via a microextrusion printing principle using 3D models, which are reverse engineered from patient anatomies by 3D scanning. The bifurcating pathways are augmented with 3D printed biomimetic physical cues (microgrooves) and path‐specific biochemical cues (spatially controlled multicomponent gradients). In vitro studies reveal that 3D printed physical and biochemical cues provide axonal guidance and chemotractant/chemokinetic functionality. In vivo studies examining the regeneration of bifurcated injuries across a 10 mm complex nerve gap in rats showed that the 3D printed scaffolds achieved successful regeneration of complex nerve injuries, resulting in enhanced functional return of the regenerated nerve. This approach suggests the potential of 3D printing toward advancing tissue regeneration in terms of: (1) the customization of scaffold geometries to match inherent tissue anatomies; (2) the integration of biomanufacturing approaches with computational modeling for design, analysis, and optimization; and (3) the enhancement of device properties with spatially controlled physical and biochemical functionalities, all enabled by the same 3D printing process. 相似文献