Novel N-Mannich base-type derivatives of the antimalarial drug amodiaquine were synthesised by reaction with tertiary N-chloromethylamides. With the exception of the derivative of ethyl hippurate, all the so-formed (1-amidomethyl-1H-quinolin-4-ylidene)arylamines displayed high chemical and enzymatic stability. These compounds displayed antimalarial activity against the multi-drug resistant Plasmodium falciparum strain Dd2 (IC50 values 15-31 nM) and demonstrated no significant loss in activity compared to amodiaquine (IC50 30 nM). 相似文献
Six‐membered cyclic α‐aminonitrile has been prepared from anodic cyanation of N‐benzylpiperidine. Good yields of α‐aminonitriles could be obtained through potentiostatic electrolysis under different conditions. The results also explain why high yield α‐aminonitriles could not be obtained under constant current electrolysis. 相似文献
Side-chain engineering has been demonstrated as an effective method for fine-tuning the optical, electrical, and morphological properties of organic semiconductors toward efficient organic solar cells (OSCs). In this work, three isomeric non-fullerene small molecule acceptors (SMAs), named BTP-4F-T2C8, BTP-4F-T2EH and BTP-4F-T3EH, with linear and branched alkyl chains substituted on the α or β positions of thiophene as the side chains, were synthesized and systematically investigated. The results demonstrate that the size and substitution position of alkyl side chains can greatly affect the electronic properties, molecular packing as well as crystallinity of the SMAs. After blending with donor polymer D18-Cl, the prominent device performance of 18.25% was achieved by the BTP-4F-T3EH-based solar cells, which is higher than those of the BTP-4F-T2EH-based (17.41%) and BTP-4F-T2C8-based (15.92%) ones. The enhanced performance of the BTP-4F-T3EH-based devices is attributed to its stronger crystallinity, higher electron mobility, suppressed biomolecular recombination, and the appropriate intermolecular interaction with the donor polymer. This work reveals that the side chain isomerization strategy can be a practical way in tuning the molecular packing and blend morphology for improving the performance of organic solar cells.
Based on the X-ray scattering intensity theory and using the approximate expression for the atomic scattering factor, the correction factors for three crystalline peaks and an amorphous peak of Nylon 1212 were calculated and the formula of degree of crystallinity of Nylon 1212 was derived by a graphic multipeak resolution method. The degree of crystallinity calculated from the WAXD method is compatible with those obtained by density and calorimetry methods. 相似文献
In a ‘one pot’ microwave reaction, an acyl hydrazide-tethered indole underwent a 3-component condensation to form a triazine, followed by an inverse-electron demand Diels-Alder reaction and subsequent chelotropic expulsion of N2 to deliver novel, unnatural β-carboline alkaloids in good isolated yields. 相似文献
A method for the determination of trace amounts of silver with a chemically modified carbon paste electrode is described. The modified electrode is prepared by simply mixing a chelating resin (a polythioether backbone and dioxymonosulphur polyethylene polyimines in the side-chain polymer) with graphite powder and Nujol oil. By immersing the electrode in a silver sample solution (pH = 6.5–7.5), silver can be adsorbed on the electrode surface and then determined by voltammetry in a separate blank solution. The response depends on the concentration of silver and the preconcentration time. For a preconcentration time of 5 min, the detection limit is about 3 × 10?10 M and the linear range is from 5 × 10?10 to 1 × 10?7 M with a relative standard deviation of 4%. Many common metal ions have no or little effect on the determination of silver. The recommended procedure was applied to the determination of trace amounts of silver in waste water. 相似文献