Study on Fluorescence Property of Sparfloxacin Derivatizing System and its Application

Spartloxacin (SPFX) is the fourth generation of the antibacterial quinolones. Due to itsintensive and efficient antibacterial activity compared to the common quinolones '. it hasbeen widely used in clinical practice. Nevertheless. because of the structural dit'ferencesbetween SPFX and other quinolones. the fluorescence of SPFX is so weak that it can notbe determined by means of fluorescence spectra. Hence, it will be of great interest tomake a detailed study on its fluorescence enhancemen…     

磷脂酰肌醇3-激酶与其抑制剂芹菜素的分子对接

采用AutoDock3.05分子对接软件包,以磷脂酰肌醇3-激酶(PI3K)的晶体结构和芹菜素的空间结构为基础,对PI3K和芹菜素的相互作用机制进行了分子对接研究,为芹菜素的抗肿瘤机制提供理论依据.芹菜素是PI3K的有效抑制剂,分子对接结果表明,芹菜素与PI3K发生了强烈的结合作用,结合自由能达到-33.1 kJ·mol-1;结合位点位于该酶底物ATP的结合位点上,与底物形成竞争性结合,从而导致PI3K的酶活性受到抑制;在结合中,疏水力、氢键和静电作用力对芹菜素和PI3K复合物的形成与稳定发挥了重要作用.     

Spectral and Mechanistic Studies of the Reactions of Substituted 1,5-Benzothiazepine with Dichloroacetyl Chloride and Triethylamine

A lot of attentions have been paid to the synthesis of benzothiazepines and derivatives1,2 due to their significant physiological activities. It has been reported that b-lactam, a major part of the antibiotic skeleton, can be introduced to a molecule by reaction of an imine moiety with ketene3,4. We introduced a b-lactam skeleton to benzothiazepine and hoped the new compounds may possess certain biological activities. SHNH3ClCHCHCOC2H5OHSNClCla: ortho-Clb: para-Cl+PyridineScheme …     

Isolation and Characterization of C-phycocyanin from Spirulina Platensis

ＩｎｔｒｏｄｕｃｔｉｏｎＳｐｉｒｕｌｉｎａ，ａｋｉｎｄｏｆｆｉｌｉｆｏｒｍ，ｍｕｌｔｉｃｅｌｕｌａｒａｌｇａｅｔｈａｔｉｓｒｉｃｈｉｎｐｒｏｔｅｉｎ，ｆａｔ，ｖｉｔａｍｉｎ，ｍｉｎｅｒａｌ，ｃｈｌｏｒｏｐｈｙｌ，β－ｃａｒｏｔｅｎｅａｎｄｐｏｌｙｓａ...     

抗肿瘤多酸药物[Mo7O24]6-的电子结构研究

运用第一原理密度泛涵理论中的离散变分方法（ＤＦＴ－ＤＶＭ）对具有抗肿瘤活性的多酸药物三合水七钼酸异丙基胺的阴离子「Ｍｏ７Ｏ２４」＾６－进行了电子结构，获得了键级、不等价原子的电子占据数、原子净电荷，分子轨道能级以及「Ｍｏ７Ｏ２４」＾６－的ＨＯＭＯ和ＬＵＭＯ组成等数据，并对该药物的活性和作用机理从电子结构的角度进行了讨论。     

基于P-SVM的供应链企业可靠性预警研究

供应链企业可靠性是供应链可靠性的重要问题之一.在国内外研究文献综述基础上提出了供应链企业节点可靠性的初步预警指标.而后以此为基础,利用P-SVM方法完成了指标体系的构建及供应链企业可靠性预警.     

模糊因子下知识产权保护与侵犯的动态博弈分析

针对知识产权屡禁不止的侵权行为现状,运用模糊数学、数理统计方法和博弈论原理,从知识产权保护和侵犯双方效用及模型出发,以系统和动态的视角对双方行为进了博弈分析.研究结果表明保护与侵犯构成为一对均衡策略状态,其主要原因在于一定条件下,保护方期望的效用均衡处于低水平态势,从而提出在效用模糊因子的调整中不断提高保护方的动态效用水平是推进有效保护知识产权的动力途径.     

广义线性系统的内模原理

考察有外干扰作用的广义线性系统(?)这里 x∈R~n,u∈R~r,y∈R~q,z∈R~p 分别表示广义线性系统(1.1)的状态矢量、控制矢量、调节矢量和量测输出矢量。E∈R~(n×n)是降秩阵,但 det[sE-A](?)0,即[sE-A]是正则矩阵束。A,B,F,C_1,C_2,D_1,D_2是具有相应维数的矩阵。假定外部干扰 f 受常微方程模型