Synthesis and characterization of polythiophene block copolymer and fullerene derivative capable of “three‐point” complementary hydrogen bonding interactions and their application in bulk‐heterojunction solar cells

We report the synthesis and characterization of a polythiophene block copolymer (P4) selectively functionalized with diaminopyrimidine moieties and a thymine tethered fullerene derivative (F1). Self‐assembly between P4 and F1 through “three‐point” complementary hydrogen bonding is studied by ¹H NMR spectroscopy and differential scanning calorimetry. A large Stern‐Volmer constant (K_SV) of 1.2 × 10⁵ M^?1 is observed from fluorescence quenching experiments, revealing strong complexation between these two components. Solar cells employing P4 and F1 at different weight ratios as active layers are fabricated and tested; corresponding thin film morphologies are studied in detail by optical imaging and atomic force microscopy. Correlations between polymer complex structures, film morphologies, and device performance are discussed. Thermal stability of benchmark poly(3‐hexylthiophene) bulk heterojunction solar cells is found to be improved by the addition of a few weight percent of P4/F1 complexes as compatibilizers. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013 , 51, 3339–3350     

吸收型雷达无源干扰材料研究进展与应用

分析了传统无源干扰装备在作战使用中存在的局限性,指出了吸收型无源干扰材料研究的必要性。详细介绍了泡沫云、膨胀石墨、改性纤维、吸收型箔条等几种吸收型无源干扰材料的性能及研究现状,并指出目前吸收型无源干扰材料在波段覆盖、战术应用以及工程化制备等方面仍存在一定缺陷,需进一步研究探索。     

基于片上变压器耦合的CMOS功率放大器设计

设计了一个2 GHz全集成的CMOS功率放大器(PA),该PA的匹配网络采用片上变压器实现,片上变压器用来实现单端信号和差分信号之间的转换和输入、输出端的阻抗匹配。采用ADS Momentum软件对片上变压器进行电磁仿真,在2 GHz频点,输入、级间和输出变压器的功率传输效率分别为74.2%,75.5%和78.4%。该PA基于TSMC 65 nm CMOS模型设计,采用Agilent ADS软件进行电路仿真,仿真结果表明:在2.5 V供电电压、2 GHz工作频率点,PA的输入、输出完全匹配到50Ω(S11=–22.4 d B、S22=–13.5 d B),功率增益为33.2 d B,最高输出功率达到23.4 d Bm,最高功率附加效率(PAE)达到35.3%,芯片面积仅为1.01 mm2。     

偏振对DWDM系统内四波混频噪声的研究

使用了一种有效的能对四波混频(FWM)噪声对DWDM系统性能影响程度进行评估的仿真模型.通过对使用在线色散补偿与后补偿相结合的新型色散管理光纤链路进行仿真,看出每个周期跨距内的残余色散对FWM噪声有一定抑制作用,适当提高每个周期跨距内的残余色散有助于提高总的非线性容限和系统的整体性能.     

Alginate‐Based Microcapsules with a Molecule Recognition Linker and Photosensitizer for the Combined Cancer Treatment

A reactive template method was used to fabricate alginate‐based hydrogel microcapsules. The uniform and well‐dispersed hydrogel capsules have a high drug loading capacity. After they are coated by a folate‐linked lipid mixture on the surface, the capsules possess higher cell uptake efficiency by the molecule recognition between folate and the folate‐receptor overexpressed by the cancer cells. Moreover, in this bioconjugate, the lipid could remarkably reduce the release rate of hydrophilic doxorubicin from the hydrogel microcapsules and encapsulate the hydrophobic photosensitizer hypocrellin B. The biointerfaced capsules could be used as drug carriers for combined treatment against cancer cell proliferation in vitro; this was much more effective than chemotherapy or photodynamic therapy alone.     

Highly selective synthesis of single-walled carbon nanotubes from methane in a coupled Downer-turbulent fluidized-bed reactor

For the synthesis of single-walled carbon nanotubes (SWCNTs) from CH₄ over a Fe/MgO catalyst, we proposed a coupled Downer-turbulent fluidized-bed (TFB) reactor to enhance the selectivity and yield (or production rate) of SWCNTs. By controlling a very short catalyst residence time (1–3 s) in the Downer, only part of Fe oxides can be reduced to form Fe nano particles (NPs) available for the growth of SWCNTs. The percentage of unreduced Fe oxides increased and the yield of SWCNTs decreased accordingly with the increase of catalyst feeding rate in Downer. SWCNTs were preferentially grown on the catalyst surface and inhibited the sintering of the Fe crystallites which would be formed thereafter in the downstream TFB, evidenced by TEM, Raman and TGA. The coupled Downer-turbulent fluidized-bed reactor technology allowed higher selectivity and higher production rate of SWCNTs as compared to TFB alone.     

A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-β-lactamase-1

New Delhi metallo-β-lactamase-1 (NDM-1) has emerged as a major global threat to human health for its rapid rate of dissemination and ability to make pathogenic microbes resistant to almost all known β-lactam antibiotics. In addition, effective NDM-1 inhibitors have not been identified to date. In spite of the plethora of structural and kinetic data available, the accurate molecular characteristics of and details on the enzymatic reaction of NDM-1 hydrolyzing β-lactam antibiotics remain incompletely understood. In this study, a combined computational approach including molecular docking, molecular dynamics simulations and quantum mechanics/molecular mechanics calculations was performed to characterize the catalytic mechanism of meropenem catalyzed by NDM-1. The quantum mechanics/molecular mechanics results indicate that the ionized D124 is beneficial to the cleavage of the C–N bond within the β-lactam ring. Meanwhile, it is energetically favorable to form an intermediate if no water molecule coordinates to Zn2. Moreover, according to the molecular dynamics results, the conserved residue K211 plays a pivotal role in substrate binding and catalysis, which is quite consistent with previous mutagenesis data. Our study provides detailed insights into the catalytic mechanism of NDM-1 hydrolyzing meropenem β-lactam antibiotics and offers clues for the discovery of new antibiotics against NDM-1 positive strains in clinical studies.