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161.
Chen Xiuqing Ma Kai Geng Deqin Zhai Jingxuan Liu Wei Zhang Hongwei Zhu Tingting Piao Xue 《Wireless Personal Communications》2019,109(3):1747-1767
Wireless Personal Communications - In order to support robust implementation of IoT, many schemes have been done to provide privacy, anonymity, scalability and customizability. Ray et al.’s... 相似文献
162.
In this paper, a paradigm is developed to design the linear-phase FIR multiple-notch filters with variable notch frequencies. The design procedure can be proceeded through two steps: First, a linear-phase narrow-band low-pass filter met the given bandwidth and stopband ripple specifications is designed. Second, a tuning procedure is applied to the computed low-pass filter to yield the desired multiple-notch filter. When the notch frequencies are varied, the same tuning procedure can be employed to render the multiple-notch filter with the new set of the notch frequencies. The tuning procedure employed reduces the computational complexity of designing the multiple-notch filter with the new set of the notch frequencies. The simulation results demonstrate the effectiveness of our scheme. 相似文献
163.
计算机网络工程实验优化探索 总被引:4,自引:0,他引:4
实验教学是计算机专业教学活动中的一个重要环节,现如今实验教学环节中存在着实验设备滞后、实验内容单一、学生实验积极性没有充分调动等众多问题。从以上三方面展开《计算机网络工程》课程的实验教学研究,提出将网络仿真工具应用于计算机网络实验教学、强调学生在实验中的主体作用、将实验项目模块化、搭建虚拟网络实验平台等多种优化策略。实践证明这些优化方案在网路工程实验环节中取得了良好效果。 相似文献
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运营商为了抢占市场先机、增强综合竞争力、大幅缩短建设周期、节省建设投资,越来越多的考虑购买或租赁老厂房进行改造成为IDC的建设模式,并形成了许多非常成功的案例.本文从IDC建设面临的困难出发,初步研究老厂房改造的政策支持和发展现状,分析老厂房改造数据中心的可行性、发展现状、主要优势、典型案例,期待老厂房改造数据中心得到更广泛的应用. 相似文献
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169.
We develop a model of CA3 neurons embedded in a resistive array to mimic the effects of electric fields from a new perspective. Effects of DC and sinusoidal electric fields on firing patterns in CA3 neurons are investigated in this study. The firing patterns can be switched from no firing pattern to burst or from burst to fast periodic firing pattern with the increase of DC electric field intensity. It is also found that the firing activities are sensitive to the frequency and amplitude of the sinusoidal electric field. Different phase-locking states and chaotic firing regions are observed in the parameter space of frequency and amplitude. These findings are qualitatively in accordance with the results of relevant experimental and numerical studies. It is implied that the external or endogenous electric field can modulate the neural code in the brain. Furthermore, it is helpful to develop control strategies based on electric fields to control neural diseases such as epilepsy. 相似文献
170.
Fangjun Liu Dun Wang Jiaqi Wang Liwei Ma Cuiyun Yu Hua Wei 《Molecules (Basel, Switzerland)》2022,27(9)
Bottlebrush copolymers with different chemical structures and compositions as well as diverse architectures represent an important kind of material for various applications, such as biomedical devices. To our knowledge, zwitterionic conjugated bottlebrush copolymers integrating fluorescence imaging and tumor microenvironment-specific responsiveness for efficient intracellular drug release have been rarely reported, likely because of the lack of an efficient synthetic approach. For this purpose, in this study, we reported the successful preparation of well-defined theranostic zwitterionic bottlebrush copolymers with unique brush-on-brush architecture. Specifically, the bottlebrush copolymers were composed of a fluorescent backbone of polyfluorene derivate (PFONPN) possessing the fluorescence resonance energy transfer with doxorubicin (DOX), primary brushes of poly(2-hydroxyethyl methacrylate) (PHEMA), and secondary graft brushes of an enzyme-degradable polytyrosine (PTyr) block as well as a zwitterionic poly(oligo (ethylene glycol) monomethyl ether methacrylate-co-sulfobetaine methacrylate) (P(OEGMA-co-SBMA)) chain with super hydrophilicity and highly antifouling ability via elegant integration of Suzuki coupling, NCA ROP and ATRP techniques. Notably, the resulting bottlebrush copolymer, PFONPN9-g-(PHEMA15-g-(PTyr16-b-P(OEGMA6-co-SBMA6)2)) (P2) with a lower MW ratio of the hydrophobic side chains of PTyr and hydrophilic side chains of P(OEGMA-co-SBMA) could self-assemble into stabilized unimolecular micelles in an aqueous phase. The resulting unimolecular micelles showed a fluorescence quantum yield of 3.9% that is mainly affected by the pendant phenol groups of PTyr side chains and a drug-loading content (DLC) of approximately 15.4% and entrapment efficiency (EE) of 90.6% for DOX, higher than the other micelle analogs, because of the efficient supramolecular interactions of π–π stacking between the PTyr blocks and drug molecules, as well as the moderate hydrophilic chain length. The fluorescence of the PFONPN backbone enables fluorescence resonance energy transfer (FRET) with DOX and visualization of intracellular trafficking of the theranostic micelles. Most importantly, the drug-loaded micelles showed accelerated drug release in the presence of proteinase K because of the enzyme-triggered degradation of PTyr blocks and subsequent deshielding of P(OEGMA-co-SBMA) corona for micelle destruction. Taken together, we developed an efficient approach for the synthesis of enzyme-responsive theranostic zwitterionic conjugated bottlebrush copolymers with a brush-on-brush architecture, and the resulting theranostic micelles with high DLC and tumor microenvironment-specific responsiveness represent a novel nanoplatform for simultaneous cell image and drug delivery. 相似文献