光热干涉检测系统的实验参数选择

为了研究实验参数对光热干涉检测结果的影响,根据等厚干涉测量原理,利用赛德倾斜像差建立了相应的光热干涉测量模型.通过对探测光源的分析,利用随机函数建立一般性光源模型,定义了光源均匀度.在此基础上通过数值模拟,对不同光源均匀性下实验现象进行仿真,分析了光源均匀性对干涉测量结果的影响.分析表明,探测光源均匀性对热吸收干涉测量结果的影响可以忽略.同时还对比分析了不同探测器接受口径对测量结果的影响.结果显示,当探测器接收口径R=0.315cm时,在0～0.6λ的光热位移内光热信号呈单调下降,而且条纹对比度相对较大.通过曲线拟合得到在弱吸收情况下光热信号与光热位移的一个简单经验公式.     

XeF2光解离波的空间传输对形成XeF(C-A)激光的影响

利用XeF2光解离波图像,测量了现有激光实验条件下的解离波半径及传输速度,解离波厚度为5～8mm,传输速度随泵浦时间的增加而减慢,平均速度约13km／s。选择四种不同的腔轴位置,腔轴距泵浦源表面的距离d分别为10、13、16、20mm,激光实验结果表明,XeF2光解离波的空间传输对XeF（C—A）激光的形成有影响,激光形成时间、脉宽均随腔轴远离泵浦源而增加;输出能量在腔轴取13mm处最大。     

复动量表象方法对奇特核中晕现象的研究

晕现象的研究使人们对核结构有了新的认识。连续谱,尤其是连续谱中的共振态在其中扮演着重要角色。复动量表象(CMR)方法不仅能够统一描述束缚态、共振态和连续谱,而且能够很好地描述窄共振和宽共振。本文介绍了CMR方法对原子核共振态的研究。给出了31Ne和19C等核的束缚态和共振态的单粒子能量随形变参数β₂的变化规律,分析了19C和31Ne中单中子晕形成的物理机制和在中子数N=20附近能级反转的原因,并预测了比37Mg重的核中的单中子晕现象,这一预测结果对在实验中寻找较重的晕核具有一定的参考价值。这些研究表明CMR 方法不仅适用于描述稳定核,也适用于描述具有弥散物质分布的奇特核。     

基于液相掺杂的低损耗近等厚芯层掺稀土光纤

过高的纤芯损耗和纤芯折射率非均匀性严重制约了掺稀土光纤在高功率光纤激光器中的应用,提出一种基于液相掺杂的低损耗近等厚芯层掺稀土光纤的工艺方法.结合改良的化学气相沉积(MCVD)溶液掺杂法制备了含有多层疏松层的掺稀土光纤预制棒,理论分析了光纤预制棒缩棒前、后芯层差的变化原理,采用流量递减沉积工艺降低了缩棒后不同芯层之间的...     

Target Design of Novel Histone Deacetylase 6 Selective Inhibitors with 2-Mercaptoquinazolinone as the Cap Moiety

Epigenetic alterations found in all human cancers are promising targets for anticancer therapy. In this sense, histone deacetylase inhibitors (HDACIs) are interesting anticancer agents that play an important role in the epigenetic regulation of cancer cells. Here, we report 15 novel hydroxamic acid-based histone deacetylase inhibitors with quinazolinone core structures. Five compounds exhibited antiproliferative activity with IC₅₀ values of 3.4–37.8 µM. Compound 8 with a 2-mercaptoquinazolinone cap moiety displayed the highest antiproliferative efficacy against MCF-7 cells. For the HDAC6 target selectivity study, compound 8 displayed an IC₅₀ value of 2.3 µM, which is 29.3 times higher than those of HDAC3, HDAC4, HDAC8, and HDAC11. Western blot assay proved that compound 8 strongly inhibited tubulin acetylation, a substrate of HDAC6. Compound 8 also displayed stronger inhibition activity against HDAC11 than the control drug Belinostat. The inhibitory mechanism of action of compound 8 on HDAC enzymes was then explored using molecular docking study. The data revealed a high binding affinity (−7.92 kcal/mol) of compound 8 toward HDAC6. In addition, dock pose analysis also proved that compound 8 might serve as a potent inhibitor of HDAC11.     

占吨酮敏化的α-蒎烯的光化学异构化反应

占吨酮敏化可以显著提高α-蒎烯异构化罗勒烯的转化率.这一实验观察在反应过程的动力学分析中得到了说明,此外,也讨论了敏化异构化反应的光化学.     

罗丹明B分子印迹聚合物微球的合成及其在固相萃取中的应用

以罗丹明B为模板分子,丙烯酰胺为功能单体,乙二醇二甲基丙烯酸酯为交联剂,采用沉淀聚合法制备了罗丹明B分子印迹聚合物(MIP)微球,并用扫描电子显微镜表征。 采用紫外分光光度法测定了印迹分子罗丹明B与功能单体丙烯酰胺二者之间的结合常数(K=5.303×103 (mol/L)-1)和化学计量比(n=1)。 考察了沉淀剂的种类和用量对聚合物微球的影响。 将分子印迹聚合物微球应用于固相萃取材料自制固相萃取柱,从加标罗丹明B的红椒粉中萃取罗丹明B。 本文优化了固相萃取条件,高效液相色谱检测表明,在一定的萃取条件下,分子印迹聚合物对加标量为0.479 mg/kg的辣椒中罗丹明B的萃取加标回收率可达91.7％～103.5%。     

A Mini Review on the Functional Biomaterials Based on Poly(lactic acid) Stereocomplex

Poly(lactic acid) stereocomplex (sc-PLA) prevails over homo-poly(lactic acid)s in many aspects and showed great potential as biomaterials depending on its extraordinary biological, thermal, and mechanical properties. In the past few years, sc-PLA has gained tremendous attention as a new approach to the development of new types of functional biomaterials. This paper summarizes recent progress in the application of the concept of sc-PLA in the design and fabrication of stabilized nanoparticles and in situ gelling hydrogels for biomedical applications.     

烧结温度和升温速率对Pb(Sb1/3Mn2/3)0.05Zr0.47Ti0.48O3压电陶瓷性能的影响

采用传统固相法制备了Pb(Sb1/3 Mn2/3)0.05Zr0.47Ti0.48 O3 (PMS-PZT)压电陶瓷.利用XRD、SEM和EDS等研究PMS-PZT陶瓷体系在烧结过程中形成的过渡液相和形成过渡液相温度(1100℃)附近的升温速率对陶瓷结构、压电和介电性能的影响.结果表明:不同烧结温度下,所有样品均为单一的钙钛矿四方相,过渡液相不会对相的结构有影响,但是当烧结温度较低时,过渡液相在烧结后期以玻璃相在晶界附近富集,对陶瓷的压电和介电性能有很大影响.随着烧结温度和升温速率的升高,PMS-PZT晶粒尺寸增大,晶粒均匀性和规则性得以改善,晶化质量得到提高;d33测试和阻抗分析测试结果表明PMS-PZT样品在1100℃附近以7 ℃·min-1升温速率并在1250℃烧结时具有最好的压电和介电性能:d33 =313 C/N,kp=0.59,Qm=1481,εr=1437,tanδ=0.53;.     

A Characterization of Maximally Entangled Two-Qubit States

As already known by Rana’s result, all eigenvalues of any partial-transposed bipartite state fall within the closed interval [−12,1]. In this note, we study a family of bipartite quantum states where the minimal eigenvalues of partial-transposed states are −12. For a two-qubit system, we find that the minimal eigenvalue of its partial-transposed state is −12 if and only if such a two-qubit state is maximally entangled. However this result does not hold in general for a two-qudit system when the dimensions of the underlying space are larger than two.