Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications

Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's disease, and cancer. This comprehensive account summarizes the recent progress (2014–present) in the development of bryostatins, including their total synthesis and biomedical applications. An emphasis is placed on the discussion of bryostatin 1 , the most-studied analogue to date. This review highlights the synthetic and biological challenges of bryostatins and provides an outlook on their future development.     

Et2Zn-mediated stoichiometric C(sp)-H silylation of 1-alkynes and chlorosilanes

A first example of an Et₂Zn mediated silylation of 1-aklynes is reported. A series of functional groups are tolerated in this reaction. Mechanistic studies support Zn alkynilides as intermediates in the reaction. This reaction protocol provides a practical method for the preparation of alkynylsilanes and expands the application of organometallic zinc in organic synthesis.     

从频谱监测和国际协调探讨短波广播频段扩展的可行性

短波广播能够实现远距离和大范围的覆盖，至今仍是进行地区性、全国性及国际性广播覆盖的最好手段之一。ITU在2001年4月批准的1514建议书《30MHz以下广播频段的数字声音广播系统》，正式确定了DRM系统为全球统一的数字广播系统。在短波广播由模拟向数字化过渡的进程中，如何解决短波广播频谱短缺的问题，本文根据国家相关的频谱监测和国际短波频率协调的情况，对短波广播中4～10MHz频谱的扩展可行性进行初步分析。     

探针馈电圆柱共形微带天线阻抗特性的FDTD法分析

将圆柱坐标系下非分裂式理想匹配层吸收边界条件(UPML)引入到圆柱共形微带天线的全波分析中，并给出了其中的场量迭代方程，明显地减小了计算空间，简化了编程；提出了圆柱坐标系下考虑有限尺寸探针半径的新算法，使得计算结果更加精确；应用GPOF方法预估了时域晚时响应，使计算时间减少了70％～90％。本文给出的模型能够对任意多层圆柱共形结构的微带天线进行计算，因此对此类天线的CAD设计具有实际意义。     

Multi-level attention model for tracking and segmentation of objects under complex occlusion

A multi-level attention framework for tracking and segmentation of humans and objects under complex occlusions is investigated, featuring an effective probabilistic appearance-based technique for pixel reclassification during object grouping and splitting. A novel ’spatial-depth affinity metric’ is introduced in the conventional likelihood function, utilising information of both spatial locations of pixels and dynamic depth ordering of the component objects in grouping. Depth ordering estimation is achieved through a combination of top-down and bottom-up approach. Experiments on some realworld difficult scenarios of low quality and highly compressed videos demonstrate the very promising results achieved.     

基于"层"模式的双机容错系统

容错技术广泛应用于各个行业来保证系统的冗余和可靠性。文章在分析比较当前的双机容错系统的性能优缺点后,提出了一种全新的基于“层”模式的双机容错系统解决方案。按照这种模式,可以从链路层到应用层构建一个通用的系统级的双机容错系统。文章对其实现的关键技术进行了阐述。     

一种基于无理数加密算法的数字签名方案

为了提高现代网络信息传输的安全性,利用无理数小数点后数字的无穷性、无规律性、分布均匀性,提出一种全新的加密算法,并用它所产生的密钥流进行数字签名,实现身份验证不可抵赖、信息传输无篡改,确保信息传输的完整性、真实性,达到提高加密效率、相互认证的效果。     

Ad Hoc与无线网络的扩展性研究

Ad Hoc作为无线网络的具有高抗毁性和灵活性的扩展网络,日益引人关注。本文首先从环绕网的理念入手,介绍Ad Hoc作为现有无线网络扩展的意义和优势,然后重点分析并提出融合策略以及需要思考的问题。     

On the Feasibility of Growing Pb[(Zn1/3Nb2/3)0.91Ti0.09]O3 Single Crystals

Pb[(Zn_1/3Nb_2/3)_0.91Ti_0.09]O₃ (PZNT91/9) single crystals were grown by two methods: from solution using PbO as a self‐fluxing agent (SC method) and directly from the melt without fluxing (MC method). In both growth methods, an allomeric Pb[(Mg_1/3‐Nb_2/3)_0.69Ti_0.31]O₃ (PMNT69/31) single crystal was used as a seed. X‐ray diffraction patterns of ground crystals showed that phase‐pure perovskite PZNT91/9 single crystals were successfully fabricated by the above two methods. The composition of the crystals obtained by both the SC and MC methods was analyzed using X‐ray fluorescence, which confirmed that the crystal composition is close to the nominal value, although volatilization of PbO and segregation during crystal growth are inevitable. The MC PZNT91/9 crystals exhibit excellent piezoelectric properties, with the piezoelectric constant, d₃₃, in the range of 1800–2200 pC N^–1. This value is comparable to that of the SC crystals. However, the MC crystals show an abnormal dielectric behavior. In contrast with the SC crystals, in the MC crystals a much broader dielectric peak appears in the dielectric response curves, accompanied by a much lower peak temperature of around 105 °C. Furthermore, frequency dispersion is apparent over a much wider temperature range (even more apparent than in pure relaxors), where a large, i.e., about 70 °C, full width at half maximum (FWHM) for the dielectric peaks is observed in the dielectric response. It is speculated that such an unusual phenomenon correlates with defects, microinhomogeneities, and polar regions in the as‐grown MC crystals. The origins of this abnormality have not been interpreted in detail until now. However, optical observation of the domain structure confirms that both the SC and MC crystals possess complex structural states.     

基于多线程技术的监控系统的设计

详细介绍在32位操作系统Windows95／98下，用C Builder3．0开发基于多线程技术的监控系统的有关方法。