一种基于三芯光纤的模式复用器/解复用器的设计

提出了一种基于三芯光纤的模式复用器/解复用器,三个纤芯包括两个相同的单模纤芯和一个少模纤芯,在少模纤芯中写入长周期光纤光栅以实现单模纤芯中LP01模与少模纤芯中LP11模间的转换。同时从两个单模纤芯输入LP01模,能激发少模纤芯中两个简并的LP11,a模和LP11,b模。采用光束传播法分析了该模式复用器/解复用器的耦合特性及串扰。数值模拟结果显示,若以少模纤芯中LP11模输出能量大于-1dB的波长范围作为该模式复用器/解复用器的工作带宽,则能够达到23nm,并且少模纤芯中生成的其他模式的输出能量皆比LP11模的输出能量小-21dB以上。该模式复用器/解复用器能够实现对少模光纤的模式复用与解复用,并具有极低的串扰。     

改进的kNN分类算法在工业物联网中的应用

在工业物联网中,k近邻分类(kNN)被广泛应用于缺陷产品识别和异常检测.但kNN自身存在计算复杂度高、不适用于分布式环境等缺点.因此,文中提出了一种安全有效的分布式kNN分类算法,以防止信息泄漏和控制流泄漏,同时支持分布式服务器上的大规模数据分类.首先设计了一个安全有效的向量同态加密方案.在该方案的基础上,提出了DkN...     

高比探测率和高速石墨烯/n-GaAs复合结构的光电探测器

混合结构的石墨烯/半导体光电晶体管因其超高的响应度而备受关注.然而,该类光电晶体管通过源-漏电极测试得到的比探测率(D．)容易受到1/f噪声的限制.本文制备了混合结构的石墨烯/GaAs光电探测器,通过源-栅电极测得D*大约为1.82X1011 Jones,与通过源-漏电极测量相比,D'提高了约500倍.这可归因于界面上...     

Effect of Thermal Processing on the Metabolic Components of Black Beans on Ultra-High-Performance Liquid Chromatography Coupled with High-Field Quadrupole-Orbitrap High-Resolution Mass Spectrometry

An ultra-high-performance liquid chromatography coupled with high-field quadrupole-orbitrap mass spectrometry (UHPLC-QE-MS) histological platform was used to analyze the effects of two thermal processing methods (cooking and steaming) on the nutritional metabolic components of black beans. Black beans had the most amino acids, followed by lipids and polyphenols, and more sugars. Multivariate statistical analysis indicated that heat processing significantly affected the metabolic component content in black beans, with effects varying among different components. Polyphenols, especially flavonoids and isoflavones, were highly susceptible. A total of 197 and 210 differential metabolites were identified in both raw black beans and cooked and steamed black beans, respectively. Cooking reduced the cumulative content of amino acids, lipids, polyphenols, sugars, and nucleosides, whereas steaming reduced amino acid and lipid content, slightly increased polyphenol content, and significantly increased sugar and nucleoside content. Our results indicated that metabolic components were better retained during steaming than cooking. Heat treatment had the greatest impact on amino acids, followed by polyphenols, fatty acids, sugars, and vitamins, indicating that cooking promotes the transformation of most substances and the synthesis of a few. The results of this study provide a basis for further research and development of nutritional products using black beans.     

DNA Interaction,DNA Photocleavage,Photocytotoxicity In Vitro,and Molecular Docking of Naphthyl-Appended Ruthenium Complexes

With the development of metal-based drugs, Ru(II) compounds present potential applications of PDT (photodynamic therapy) and anticancer reagents. We herein synthesized two naphthyl-appended ruthenium complexes by the combination of the ligand with naphthyl and bipyridyl. The DNA affinities, photocleavage abilities, and photocytotoxicity were studied by various spectral methods, viscosity measurement, theoretical computation method, gel electrophoresis, and MTT method. Two complexes exhibited strong interaction with calf thymus DNA by intercalation. Production of singlet oxygen (¹O₂) led to obvious DNA photocleavage activities of two complexes under 365 nm light. Furthermore, two complexes displayed obvious photocytotoxicity and low dark cytotoxicity towards Hela, A549, and A375 cells.     

Established Liposome-Coated IMB16-4 Polymeric Nanoparticles (LNPs) for Increasing Cellular Uptake and Anti-Fibrotic Effects In Vitro

As a global health problem, liver fibrosis still does not have approved treatment. It was proved that N-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamide) benzamide (IMB16-4) has anti-hepatic fibrosis activity. However, IMB16-4 displays poor water solubility and poor bioavailability. We are devoted to developing biodegraded liposome-coated polymeric nanoparticles (LNPs) as IMB16-4 delivery systems for improving aqueous solubility, cellular uptake, and anti-fibrotic effects. The physical states of IMB16-4−LNPs were analyzed using a transmission electron microscope (TEM), high-performance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimeter (DSC). The results show that IMB16-4−LNPs increased the drug loading compared to liposomes and enhanced cellular uptake behavior compared with IMB16-4−NPs. In addition, IMB16-4−LNPs could repress the expression of hepatic fibrogenesis-associated proteins, indicating that IMB16-4−LNPs exhibited evident anti-fibrotic effects.     

凹槽叶顶冷气射流对涡轮叶尖泄漏流动的影响

涡轮叶尖泄漏流动对涡轮通道内流动损失有着显著影响,叶顶冷气射流对控制叶尖泄漏流动和改善涡轮叶尖气热性能有重要意义.本文利用数值模拟方法,研究了叶顶冷气喷射位置和喷射流量对高压涡轮凹槽叶顶间隙泄漏流动控制的影响.文中重点分析了泄漏流动结构及涡轮气动效率的变化,探讨了冷气对刮削涡这一间隙内主控流动结构演化的影响.研究表明,...     

Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways

Drug resistance is still an obstacle in cancer therapy, leading to the failure of tumor treatment. The emergence of tumor drug resistance has always been a main concern of oncologists. Therefore, overcoming tumor drug resistance and looking for new strategies for tumor treatment is a major focus in the field of tumor research. Natural products serve as effective substances against drug resistance because of their diverse chemical structures and pharmacological effects. We reviewed the signaling pathways involved in the development of tumor drug resistance, including Epidermal growth factor receptor (EGFR), Renin-angiotensin system (Ras), Phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), Wnt, Notch, Transforming growth factor-beta (TGF-β), and their specific signaling pathway inhibitors derived from natural products. This can provide new ideas for the prevention of drug resistance in cancer therapy.     

Synthesis and Anti-Neuroinflammatory Activity of 1,7-diphenyl-1,4-heptadien-3-ones in LPS-Stimulated BV2 Microglia Via Inhibiting NF-κB/MAPK Signaling Pathways

A series of 1,7-diphenyl-1,4-heptadien-3-ones with various substituents (HO-, CH₃O-, CH₃-, Cl-) on the phenyl rings were synthesized and evaluated for anti-neuroinflammatory effects in LPS-stimulated BV2 microglia. The pharmacological results showed that the target compounds bearing methoxy groups greatly inhibited LPS-induced NO release, and that the active compounds CU-19 and CU-21 reduced the level of NO, TNF-α, IL-6 and PGE-2, downregulated the expression of COX-2 and iNOS in LPS-stimulated BV2 cells. A study of the mechanism of action revealed that CU-19 and CU-21 inhibited the nuclear translocation of NF-κB and phosphorylation of MAPKs (ERK, JNK, and p38). A preliminary pharmacokinetic study in rats revealed that the pharmacokinetic properties of CU-19 and CU-21 were dramatically ameliorated in comparison with the pharmacokinetic properties of curcumin.     

基于流率入树枝向量行列式算法的循环经济系统增长反馈分析

设计了江西省萍乡市兰坡村“猪-沼-粮”循环经济系统工程的流率入树模型,并利用流率入树枝向量行列式算法得到了系统的反馈环,在反馈环基础上,构造了系统增长基模,得到结论,以沼气工程（沼肥）为纽带,发展养殖业能实现生猪养殖、稻谷种植和蔬菜种植之间的良性循环,能够达到稻谷增产和收入增长,在微观层面上实现粮食安全和农民增收双赢。