三氯化镱催化丙烯酸酯与呋喃成环反应的研究

D iels-A lder反应具有立体专一性和很好的区域选择性,已被大量应用于天然有机化合物、香料、药物等的合成中。一般说来,D iels-A lder反应在加热条件下即能发生,但加热往往导致反应的区域选择性和立体专一性下降,而研究表明,路易斯酸催化下的D iels-A lder反应在不同程度上表现出或反应速度加快,或产率提高,或条件温和,尤其是区域选择性和立体专一性得到提高等良好特性。呋喃类化合物由于呋喃环所具有的芳香性而较难与一般的亲双烯发生D iels-A lder反应。如呋喃和丙烯酸甲酯在加热条件下反应2~3个月,产率只能达到50%,且反应温度的提高…     

化学史课程资源的开发特点及途径

在素质教育全面实施的过程中,课程资源的短缺是一个不可忽视的问题,而化学史又是多年来在化学教学中经常被忽略的内容。本文结合化学史课程资源开发的5个特点,提出了化学史课程资源开发的一些具体途径：研究化学发展历史;了解化学家的生平及研究成果;挖掘化学史故事;探寻化学史图片;筛选古代文献资料中的化学部分;分析古代科学技术成果中化学的作用。     

有机化学课程中的绿色化学教育

介绍了在有机化学课程教学实践中对学生进行绿色化学教育的做法和建议,其中包括反应试剂的绿色化,反应条件的绿色化,目标产物绿色化。     

熔融反应合成2,2′-联吡啶桥联二（4,4′-联吡啶）类哑铃型化合物

无溶剂反应;联吡啶;固相熔融;哑铃型化合物     

氧氟沙星的核磁共振波谱性质研究

结合1H, 13C NMR, DEPT, COSY, HSQC, HMBC谱和碳氟偶合裂分行为, 对酸性及碱性溶液中氧氟沙星(Ofloxacin, OFL)的1H和13C谱分别进行归属, 研究了哌嗪环亚甲基构成的AA'BB'复杂自旋体系中各H的化学位移. 发现噁嗪环上的甲基处于直立键; 5H在酸性溶液中化学位移移向低场, 这可能与形成C—H…O弱氢键有关; 在碱性溶液中, OFL的羧基变为羧酸根, 造成羧基和羰基周围碳原子上π电子重新分布, 导致相应C的化学位移和碳氟偶合常数发生明显变化.     

Amide Ionic Liquids（AILs）/L-Proline Synergistic Catalyzed Asymmetric Mannich Reactions

IntroductionThe Mannich reaction is one of the most importantreactions for the formation of C—C bonds in the organicsynthetic chemistry, and this reaction has been widelyused for the synthesis of secondary and tertiary aminederivatives that is considered…     

Expression of Catalytic Domain of Protein Tyrosine Phosphatase 1B and Preparation of Its Polyclonal Antibody

This study focuses on the expression of human protein tyrosine phosphatase 1B(PTP1B) catalytic domain (△PTP1B) and preparation of polyclonal antibody against △PTP1B. △PTP1B gene was PCR amplified with the cDNA of human PTP1B as the template, and cloned into the pT7 expression vector. The recombinant pT7-△PTP1B was expressed in E. coli Rosetta( DE3 ) host cells and purified. The antiserum was prepared by immunizing rabbit with purified recombinant △PTP1B. The polyclonal antibody against △PTP1B was purified by PVDF immobilized antigen affinity chromatography. △PTP1B was correctly cloned, expressed, and purified as confirmed by PCR, DNA sequence ratio) and 0. 1 ng, respectively. This study provides an important basis for further studying the biological function of PTP1B and its relationship with human diseases.     

一种新的质子泵抑制剂苯并咪唑衍生物的合成与表征

以2-巯基苯并咪唑为原料,在碱性条件下与自制的盐酸2-氯甲基-4-(3-甲氧基丙氧基)-3-甲基吡啶缩合得2-{[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基硫}-1H-苯并咪唑,再经氧化、成盐反应生成产物2-{[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基亚硫酰基}-1H-苯并咪唑钠,总收率66%.此产物通过红外光谱、核磁共振、质谱表征加以确认.     

不同环境蔬菜中铅污染的研究

用原子吸收分光光度计石墨炉法分析了公路附近的蔬菜中铅的含量。结果表明,蔬菜中铅的含量还与其距离公路的远近有关,蔬菜与空气接触程度也有关;不同种类蔬菜中的铅污染有差异。     

配合物[Mn(phendione)(PDC)(H2O)2]·2H2O的合成与晶体结构

The title compound [Mn(phendione)(PDC)(H₂O)₂]·2H₂O (H₂PDC=pyridine-2，6-dicarboxylic acid) has been prepared in aqueous solution and characterized by single X-ray diffraction structure determination， elemental analysis， IR spectroscopy， and thermal analyses. The compound crystallizes in Monoclinic system， space group C2/c， a=1.017 51(11) nm， b=1.483 25(11) nm， c=1.461 21(13) nm， β=109.86(10)°， V=2.074 1(3) nm³， Z=4， F(000)=1 028， μ=0.701 mm^-1， D_c=1.609 g·cm^-3， R₁=0.028 9， wR₂=0.078 8 [I>2σ(I)]. Crystal structure reveals that complex consists of one-dimensional chain framework bridged by hydrogen bonds that formed by uncoordinated water and oxygen atom of carboxyl group in PDC^2-. Furthermore， the complexes form a three-dimensional super-molecular structure through hydrogen bonds. CCDC: 648570.