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Shai Rahimipour Georg Gescheidt Itzhak Bilkis Mati Fridkin Lev Weiner 《Applied magnetic resonance》2010,37(1-4):629-648
In this review article, the structure, properties, stability and biological application of redox-active quinones are presented. A series of quinoid molecules is evaluated in terms of their ability to act as electron-transfer active compounds using cyclovoltammetric, electron paramagnetic resonance (EPR) and spin-trapping techniques. Redox potentials and electron distribution of the intermediate radical anions are shown to be decisive factors for the generation of reactive oxygen species (ROS). Mechanisms of ROS generation in dark by biological electron-transfer reaction or under photoexcitation have been proposed and experimentally verified. For site-specific damage of tumors, some quinone derivatives were covalently bound with the luteinizing hormone-releasing hormone (LH–RH or GnRH) that produces specific complexes with receptors on the surface of cancer cells. The properties of obtained conjugates to be bound with the different lines of cancer cells (αT3-1, M2R, LNCaP) were tested. EPR was used for the estimation of efficacy of ROS production by the conjugates in solution and in the complex with cancer cells. The toxicity of these conjugates as well as their stability in the stimulated oxidative stress were tested. The proposed approach could be useful in creating a new family of addressed anticancer drugs, including compounds for the treatment of tumors by photodynamic therapy. 相似文献
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The essential feature of peer methods for initial value problems is that all stages have the same order. Hence, dense output is easily available by interpolation. However, continuity of the output requires that the methods possess the FSAL-property (first same as last) well known from one-step methods. An additional advantage of such methods is an increase of the number of stages and the order without increasing the computational effort of the scheme or the number of computing cores for parallel methods. We derive several FSAL peer methods with 3 to 9 stages and compare their numerical efficiency with existing methods in the case of explicit parallel and implicit sequential peer methods. 相似文献
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Houxun Miao Weiner A.M. Mirkin L. Miller P.J. 《Photonics Technology Letters, IEEE》2008,20(8):545-547
We demonstrated all-order polarization-mode dispersion compensation using a virtually imaged phased-array-based transmission pulse shaper. We reduced the pulsewidth of polarization-mode dispersed pulses from more than 100 ps to their original 15 ps. 相似文献
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Halorhodopsin from Natronomonas pharaonis (pHR) is a light-driven chloride pump that transports a chloride anion across the plasma membrane following light absorption by a retinal chromophore which initiates a photocycle. Analysis of the amino acid sequence of pHR reveals three cysteine residues (Cys160, Cys184, and Cys186) in helices D and E. Here we have labeled the cysteine residues with nitroxide spin labels and studied using electron paramagnetic resonance (EPR) spectroscopy their mobility, accessibility to various reagents, and the distance between the labels. It was revealed by following the d(1)/d parameter that the distance between the spin labels is ca. 13-15 Angstrom. The EPR spectrum suggests that one label has a restricted mobility while the other two are more mobile. Only one label is accessible to hydrophilic paramagnetic broadening reagents leading to the conclusion that this label is exposed to the water phase. All three labels are reduced by ascorbic acid and reoxidized by molecular oxygen. The rate of the oxidation is accelerated following retinal irradiation indicating that the protein experiences conformation alterations in the vicinity of the labels during the pigment photocycle. It is suggested that Cys186 is exposed to the bulk medium while Cys184, located close to the retinal ionone ring, exhibits an immobilized EPR signal and is characterized by a hydrophobic environment. 相似文献