The roles of cysteines in the heme domain of human soluble guanylate cyclase

Soluble guanylate cyclase(sGC) is a critical heme-containing enzyme involved in NO signaling.The dimerization of sGC subunits is necessary for its bioactivity and its mechanism is a striking and an indistinct issue.The roles of heme domain cysteines of the sGC on the dimerization and heme binding were investigated herein.The site-directed mutations of three conserved cysteines(C78A,C122A and C174S) were studied systematically and the three mutants were characterized by gel filtration analysis,UV-vis spectroscopy and heme transfer examination.Cys78 was involved in heme binding but not referred to the dimerization,while Cys174 was demonstrated to be involved in the homodimerization.These results provide new insights into the cysteine-related dimerization regulation of sGC.     

X-ray diffraction studies on crystallite size evolution of CoFe2O4 nanoparticles prepared using mechanical alloying and sintering

Nanosized cobalt ferrite spinel particles have been prepared by using mechanically alloyed nanoparticles. The effects of various preparation parameters on the crystallite size of cobalt ferrite which includes milling time; ball-to powder weight ratio (BPR) and sintering temperature, were studied using X-ray diffractometer (XRD). Scherrer's equation was used to study the crystallite size evolution of the as-prepared materials. The results of the as-milled sample revealed that both milling time and BPR plays a role in determining the crystallite size of the milled powder. However, where sintering is involved, the sintering temperature results in grain growth, and thus plays a dominant role in determining the final crystallite size of the samples sintered at higher temperature (above 900 °C). From the vibrating-sample magnetometer (VSM) measurement it was observed that the coercivity of the as-milled samples without sintering is almost negligible, which is a type characteristic of superparamagnetic material. However, for the sintered samples, the saturation increases while coercivity decreases with increases sintering temperature.     

基于主成分的改进雷达图及其在综合评价中的应用

本文从可视化角度出发,在总结传统可视化方法因优点与不足的基础上,将主成分分析、因子分析与雷达图结合,改进了传统的可视化方法。并将新的可视化方法引入到综合评价中,提出了一种基于雷达图面积的综合评价模型,实例验证该种方法切实有效。     

An efficient blue-emitting phosphor LiCaPO4:Eu2+ for white LEDs

A new blue-emitting phosphor LiCaPO₄: Eu²⁺ was synthesized by solid state reaction at a relatively low temperature of 900 °C. It gives a single intense emission band centering at 470 nm, which corresponds to the 4f⁶5d¹→4f⁷ transition of Eu²⁺. The dependence of luminescence intensities on Eu²⁺ concentration was investigated. The phosphor, with a single excitation band extending from 250 to 400 nm, could be efficiently excited by near-ultraviolet light-emitting diodes and is believed to be a promising blue-emitting phosphor for white light-emitting diodes.     

Theoretical Study of Interesting Fine-Structure Splittings Based on a Scenario for Precise Calculations

Based on the multi-configuration Dirac-Fock self-consistent field method, a scenario has been presented to calculate the fine-structure energy levels of C^2＋ and Si^2＋ excited states （31 D2 and 33D1,2,3）. The Breit interactions and quantum electrodynamics corrections are added as perturbations. The present calculation results are found to be in excellent agreement with the experimental data. By means of the precise calculation procedure, we elucidate that four competitive mechanisms influence the interesting fine-structure splittings in C^2＋ and Si^2＋, such as spin-orbit interactions, relativistic corrections of exchange interactions, the Breit interactions and electron correlation effects. Furthermore, the mechanism of relativistic correction of exchange interactions has been studied clearly. We elucidate that the inner shell 2p1/2,3/2 orbitals are essential to relativistic corrections of exchange interactions which are crucial for the final anomalous fine-structure splittings.     

2009年10月国内手机市场分析及进网动态监测

1 手机市场总体情况及特点 1．1 10月手机市场总体发展情况 2009年10月国内手机市场较上月相比呈现大幅下滑的态势，其市场投放量为1259．2万部，同比下降28．46％，环比下降66．13％。本月共有133款新品手机上市，同比下降16．88％，环比下降70．83％。     

Optimization of miniature coarse wavelength division multiplexing module

This paper provides a noval solution to optimize the characteristics of a miniature coarse wavelength division multiplexing (mini-CWDM) module by employing collimators with plano-convex rod lenses of different radii. The 8-channel modules before optimization show maximum loss of 0.77 dB and nonuniformity of 0.34 dB. After optimization, the maximum loss and nonuniformity are reduced to 0.50 dB and 0.11 dB, respectively.     

On Pseudo-Holomorphic Curves from Two-Spheres into a Complex Grassmannian G（2, 5）

Let s ： S2 → G（2, 5） be a linearly full totally unramified pseudo-holomorphic curve with constant Gaussian curvature K in a complex Grassmann manifold G（2, 5）. It is prove that K is either 1 4 1 or 4/5 if s is non-±holomorphic. Furthermore, K = 1/3 if and only if s is totally real. We also prove that the Gaussian curvature K is either 1 or -4/3 if s is a non-degenerate holomorphic curve under some conditions.     

Numerical method for the inverse heat transfer problem in composite materials with Stefan-Boltzmann conditions

In this paper, one specific kind of heat transfer problem with nonlinear Stefan-Boltzmann conditions are considered in a three dimensional multi-layer domain. Theoretical results for forward and inverse problems are presented. Numerical simulations of specific models from applications are provided to demonstrate the heat transfer process in the composite materials of forward problem. One reconstruction method is proposed to find the corrosion part, and the numerical examples show that the reconstruction algorithm is effective.