Synthesis of Novel Modified Guanidines: Reaction of Dicyandiamide with Amino Acids,Amides, and Amines in Aqueous Medium

Reaction of dicyandiamide with series of amino acids afforded guanidinyl pyrazolones 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , respectively. Although reaction of dicyandiamide with urea, acetamide, bezamide, allantion, p‐aminobenzoic acid, sulphanilic acid, and adenine gave biguanides 20 , 21 , 22 , 23 , 24 , 25 , 26 , respectively. All compounds have been characterized on the basis of IR and ¹H‐NMR.     

Synthesis of Some Novel Imidazopyrazole and Pyrazolopyrimidine Derivatives

5‐Amino‐3‐anilino‐1H‐pyrazole‐4‐carbonitrile 1 was alkylated with various halo reagents under phase transfer conditions to give the corresponding imidazopyrazole derivatives 2a , 2b , 2c , 3 , 4 , 5 , 6 . Pyrazolo[1,5‐a] pyrimidine derivatives 11 , 12 , 13 , 14 were prepared by treating compound 1 with different dicarbonyl reagents, namely, diethymalonate, ethyl 3‐oxo‐3‐phenylpropanoate, pentane‐2,4‐dione or ethyl 3‐oxobutanoate.     

Rigorous Full-Wave Analysis of Rectangular Microstrip Patch Antenna on Suspended and Composite Substrates

In this paper, Galerkin’s method in the Fourier transform domain is applied to the determination of the resonant frequencies and half-power bandwidth of rectangular microstrip patch on composite and suspended substrates. Using Galerkin’s method in solving the integral equation numerically, the complex resonant frequency of the microstrip antenna on suspended and composite substrates is studied with sinusoidal functions as basis functions, which show fast numerical convergence. The validity of the solution is tested by comparison of the computed results with experimental data. Finally, numerical results for the effects of suspended and composite substrates on the resonant frequency and half-power bandwidth are also presented.     

Analysis of capacity and coverage region for Rayleigh fading MIMO relay channel

In this paper, we consider Rayleigh fading MIMO relay channel with channel state information at the receivers. First, we extend the previously obtained results for the ergodic capacity of uncorrelated and semi‐correlated MIMO channels and derive closed‐form expressions for the capacity bounds of MIMO relay channel. Next, we study this channel from a new point of view, maximizing coverage region for a desired transmission rate, and investigate the optimal relay location in the sense of maximizing coverage region. However, in order to overcome the mathematical complexity in desired transmission rate analysis, because of the randomness of the multiple antenna channel matrices, we evaluate this rate by using an existing exact formula and also by an approximation we find in the high signal‐to‐noise ratio regime. Numerical results show a perfect match between the Monte Carlo simulations and the obtained analytical closed‐form expressions and also confirm the effectiveness of our approach in cooperative vehicular communication for determining optimal relay location at which the coverage region is maximum. Copyright © 2013 John Wiley & Sons, Ltd.     

Enantiomeric Thin-Layer Chromatographic Assay of Escitalopram in Presence of “In-Process Impurities”

JPC – Journal of Planar Chromatography – Modern TLC - A simple, rapid and precise thin-layer chromatographic (TLC) method for analysis of escitalopram oxalate (ESC-OX) (S-enantiomer) in...     

Gradient HPLC-diode array detector stability-indicating determination of lidocaine hydrochloride and cetylpyridinium chloride in two combined oral gel dosage forms

A simple, rapid, and selective HPLC-diode array detector method was developed for the simultaneous determination of lidocaine hydrochloride (LD) and cetylpyridinium chloride (CPC) in two combined pharmaceutical formulations. Effective chromatographic separation was achieved on a Zorbax SB-C8 (4.6 x 250 mm, 5 microm particle size) column with gradient elution using a mobile phase composed of 0.05 M phosphoric acid and acetonitrile. The gradient elution started with 25% (v/v) acetonitrile, ramped up linearly to 85% in 5 min, and then was constant until the end of the run. The mobile phase was pumped at a flow rate of 1.2 mL/min. The multiple wavelength detector was set at 214 and 258 nm, and quantification of the analytes was based on measuring their peak areas. The retention times for LD and CPC were about 3.4 and 7.3 min, respectively. The reliability and analytical performance of the proposed HPLC procedure were statistically validated with respect to linearity, range, precision, accuracy, selectivity, robustness, LOD, and LOQ. Calibration curves were linear in the range of 5-200 and 10-400 microg/mL for LD and CPC, respectively, with correlation coefficients > 0.999. The proposed method was proven to be stability-indicating by the resolution of the two analytes from the related substance and potential impurity (2,6-dimethylaniline) as well as from forced-degradation products. The validated HPLC method was extended to the analysis of LD and CPC in two combined oral gel preparations for which the two analytes were successfully resolved from the pharmaceutical adjuvants and quantified with recoveries not less than 97.9%.     

On the complexity of axiomatizations of the class of representable quasi‐polyadic equality algebras

Using games, as introduced by Hirsch and Hodkinson in algebraic logic, we give a recursive axiomatization of the class RQPEA _α of representable quasi‐polyadic equality algebras of any dimension α. Following Sain and Thompson in modifying Andréka’s methods of splitting, to adapt the quasi‐polyadic equality case, we show that if Σ is a set of equations axiomatizing RPEA _n for $2< n <\omegaUsing games, as introduced by Hirsch and Hodkinson in algebraic logic, we give a recursive axiomatization of the class RQPEA _α of representable quasi‐polyadic equality algebras of any dimension α. Following Sain and Thompson in modifying Andréka’s methods of splitting, to adapt the quasi‐polyadic equality case, we show that if Σ is a set of equations axiomatizing RPEA _n for $2< n <\omega$ and $l< n,$ $k < n$, k′ < ω are natural numbers, then Σ contains infinitely equations in which ? occurs, one of + or · occurs, a diagonal or a permutation with index l occurs, more than k cylindrifications and more than k′ variables occur. © 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim     

Decay of Solutions to a 2D Schroedinger Equation

Let u ∈ C（1R, H1） be the solution to the initial value problem for a 2D semilinear Schr6dinger equation with exponential type nonlinearity, given in [1]. We prove that the Lr norms of u decay as t→±∞, provided that r〉2.     

Dynamics of H and D abstraction in the reaction of Cl atom with butane-1,1,1,4,4,4-d6

We report the primary (D-atom) and secondary (H-atom) abstraction dynamics of chlorine atom reaction with butane-1,1,1,4,4,4-d(6). The H- and D-atom abstraction channels were studied over a range of collision energies: 10.4 kcal mol(-1) and 12.9 kcal mol(-1); 5.2 kcal mol(-1) to 12.8 kcal mol(-1), respectively, using crossed molecular beam dc slice ion imaging techniques. Single photon ionization at 157 nm was used to probe the butyl radical products resulting from the H- and D-atom abstraction reactions. These two channels manifest distinct dynamics principally in the translational energy distributions, while the angular distributions are remarkably similar. The reduced translational energy distribution for the primary abstraction showed marked variation with collision energy in the backward direction, while the secondary abstraction showed this variation in the forward direction.     

Detection of fentanyl in binary mixtures with cocaine by use of surface-enhanced Raman spectroscopy

Abstract

The ongoing epidemic pertaining to overdose deaths has been attributed to the synthetic opioid fentanyl due to its use as an adulterant in other, less potent drugs of abuse. Detection of low quantities of fentanyl would, therefore, be extremely useful in a forensic science laboratory. While Raman spectroscopy is particularly effective at distinguishing between classes of drugs, weak signatures can prove difficult when dealing with microscopic samples. Surface-enhanced Raman scattering spectroscopy provides the enhancement necessary to make Raman a viable approach for the detection of small amounts of fentanyl. This work explores the use of a paper-based substrate loaded with silver nanoparticles for the recovery of small quantities of fentanyl in cocaine, where it was identified at a lower limit of 500?ng (～65?ppm) in mixtures. Linear relationships were investigated between intensity and concentration for diagnostic peaks associated with fentanyl and cocaine, which in turn sheds light on the attenuation of the enhancement intensity as a result of competitive binding to silver nanoparticles. This work demonstrates a potentially simple and qualitative pathway for the forensic analysis of fentanyl as an adulterant in cocaine.