Preparation and characterization of cyclodextrin inclusion complex of naringenin and critical comparison with phospholipid complexation for improving solubility and dissolution

Naringenin, a flavonoid specific to citrus fruits shows a variety of therapeutic effects like anti-inflammatory, anticarcinogenic, and antitumour effects. But it is associated with some limitations like poor water solubility, poor dissolution, lower half-life, and rapid clearance from the body. With the aim of improving amorphous nature, water solubility, and dissolution profile of naringenin and its complexes were prepared with β-cyclodextrin in three different molar ratios (1:1, 1:2, and 1:3) by solvent evaporation method. These complexes were characterized for solubility, drug content, chemical interaction (using FTIR), phase transition behavior (using DSC), crystallinity (using XRPD), surface morphology (using SEM), and in vitro dissolution study. The results were also critically compared with the results obtained from naringenin-phospholipid complexes (from author’s previous study). The prepared complexes showed high drug content (ranging from 69.53 to 84.38 %) and about two fold improvement in water solubility (from 41.81 to 76.31 μg mL^?1 in the complex with 1:3 ratio). SEM of the complexes showed irregular and rough surface morphology. FTIR, DSC, and XRPD data confirmed the formation of the complex. Unlike the free naringenin which showed a total of only 48.78 % drug release at the end of 60 min, the complex showed 98.0–100 % in dissolution study. Thus it was concluded that the β-cyclodextrin of naringenin may be of potential use for improving bioavailability of poorly soluble phytoconstituents/herbal drugs. On critical comparison with the phospholipid complex of naringenin both the techniques were found almost equally effective in improving the solubility and the dissolution performance of naringenin in the complex form.     

Different approaches of impregnation for resolution of enantiomers of atenolol,propranolol and salbutamol using Cu(II)-l-amino acid complexes for ligand exchange on commercial thin layer chromatographic plates

Atenolol and propranolol (the β-blocking agents) and salbutamol (broncho- and vasodilator) were resolved into their enantiomers by adopting different modes of loading/impregnating the Cu(II) complexes of l-proline (l-Pro), l-phenylalanine (l-Phe), l-histidine (l-His), N,N-dimethyl-l-phenylalanine (N,N-Me₂-l-Phe), and l-tryptophan (l-Trp) on commercial precoated normal phase plates. The three different approaches were (A) using the Cu(II)-l-amino acid complex as chiral mobile phase additive, (B) ascending development of plain commercial plates in the solutions of Cu complex, and (C) using a solution of Cu(II) acetate as mobile phase additive for the commercial TLC plates impregnated with ascending development of plates in the solutions of amino acid. Spots were located using iodine vapour. The results obtained for the three methods have been compared for their efficiency and the issue of involvement of the Cu(II) cation for the best performance of the three methods has been discussed with respect to the same mobile phase. The detection limit is 0.18 μg for each enantiomer.     

Indirect enantioresolution of (R,S)‐mexiletine by reversed‐phase high‐performance liquid chromatography via diastereomerization with [(S,S)‐O,O'‐di‐p‐toluoyl tartaric acid anhydride], (S)‐naproxen and nine chiral reagents synthesized as variants of Marfey's reagent

Eleven chiral derivatizing reagents (CDRs) were used for preparation of diastereomers of (R,S)‐mexiletine containing a primary amino group in close proximity to the stereogenic center. One anhydride, namely [(S,S)‐O,O'‐di‐p‐toluoyl tartaric acid anhydride] was synthesized and (S)‐naproxen was used as such as the chiral derivatizing reagent. The other nine CDRs were synthesized by substituting one of the fluorine atoms in 1,5‐difluoro‐2,4‐dinitrobenzene with six amino acid amides and three amino acids. The diastereomers were separated by reversed‐phase high‐performance liquid chromatography. The method was validated for linearity, accuracy, limit of detection and limit of quantification. The limit of detection was found in the range of 10–30 pmol. Copyright © 2010 John Wiley & Sons, Ltd.     

A molecular dynamics study of the interaction of oleate and dodecylammonium chloride surfactants with complex aluminosilicate minerals

Surface characteristics of complex aluminosilicate minerals like spodumene [LiAl(SiO(3))(2)], jadeite [NaAl(SiO(3))(2)], feldspar [KAlSi(3)O(8)], and muscovite [K(2)Al(4)(Al(2)Si(6)O(20))(OH)(4)]) are modeled. Surface energies are computed for the cleavage planes of these minerals. Adsorption mechanisms of anionic chemisorbing type oleate and cationic physisorbing type dodecylammonium chloride molecules on two different crystal planes, that is (110) and (001), of spodumene and jadeite are studied in terms of the surface-surfactant interaction energies computed using molecular dynamics (MD) simulations. The conclusions drawn from purely theoretical computations match remarkably well with our experimental results.     

ADYTIA: Adaptive and Dynamic TCP Interface Architecture for heterogeneous networks

Due to the widespread popularity and usage of Internet of things (IoT)‐enabled devices, there is an exponential increase in the data traffic generated from these IoT devices. Most of these devices communicate with each other using heterogeneous links having constraints such as latency, throughput, and interference from concurrent transmissions. This results in an extra burden on the underlying communication infrastructure to manage the traffic within these constraints between source and destination. However, most of the existing applications use different Transmission Control Protocol (TCP) variants for traffic management between these devices and are dependent on the stage of the sender, irrespective of the application types and link characteristics. Each operating system (OS) has different TCP variant for all applications, irrespective of path characteristics. Hence, a single TCP variant cannot select the best suitable link, which results in degradation in throughput compared to the existing default. Moreover, it cannot use the full capacity of the available link for different applications and network links, especially in heterogeneous network such as IoT. To cope up with these challenges, in this paper, we propose an Adaptive and Dynamic TCP Interface Architecture (ADYTIA). ADYTIA allows the usage of different TCP variants based on application and link characteristics, irrespective of the physical links of the entire path. It allows the usage of different TCP variants based on their design principle across heterogeneous technologies, platforms, and applications. ADYTIA is implemented on NS‐2 and Linux kernel for real testbed experiments. Its ability to select the best suitable TCP variant results in 20% to 80% improvement in throughput compared with the existing default and single TCP variant on Linux and Windows.     

Software defined vehicular networks: A comprehensive review

The recent breakthroughs in the automobile industries and telecommunication technologies along with the exceptional multimodal mobility services brought focus on intelligent transportation system (ITS), of which vehicular ad hoc networks (VANETs) gain much more attention. The distinctive features of software‐defined networking (SDN) leverages the vehicular networks by its state of the centralized art having a comprehensive view of the network. Its potential to bring the flexibility, programmability and other extensive advancements to vehicular networks has set the stage for a novel networking paradigm termed as software‐defined vehicular networks (SDVNs). Many researchers have demonstrated the SDN‐based VANETs with the various configuration of the SDN components in VANET architecture. However, a compilation of the work on the SDN‐based VANET system as a whole, incorporating its architecture, use‐cases, and opportunities, is still inadequate. We start with the summary of the recent studies that exist on the SDVNs, followed by the comprehensive explanation of its components. Next, we present the taxonomy of SDVN based on the architecture modes, protocols, access technologies, and opportunities with trending technologies. Finally, we highlight the challenges, open research issues, and future research directions.     

Synthesis of succinimidyl-(S)-naproxen ester and its application for indirect enantioresolution of penicillamine by reversed-phase high-performance liquid chromatography

Synthesis of N-succinimidyl-(S)-2-(6-methoxynaphth-2-yl) propionate was carried out by the reaction of (S)-naproxen with N-hydroxysuccinimide in the presence of dicyclohexyl carbodiimide. It was characterized and was used as a chiral derivatizing reagent, under mild conditions, to form diastereomers of dl-penicillamine which were resolved by reversed-phase high-performance liquid chromatography using triethyl ammonium phosphate buffer (pH 4.0, 5mM)-acetonitrile (linear gradient (30min) of acetonitrile from 30 to 70%). Excellent separation was achieved with gradient mobile phase. The detection limit was at pmol level.     

On Lie symmetries and soliton solutions of $$$$-dimensional Bogoyavlenskii equations

The present article is devoted to find some invariant solutions of the \((2+1)\)-dimensional Bogoyavlenskii equations using similarity transformations method. The system describes \((2+1)\)-dimensional interaction of a Riemann wave propagating along y-axis with a long wave along x-axis. All possible vector fields, commutative relations and symmetry reductions are obtained by using invariance property of Lie group. Meanwhile, the method reduces the number of independent variables by one, which leads to the reduction of Bogoyavlenskii equations into a system of ordinary differential equations. The system so obtained is solved under some parametric restrictions and provides invariant solutions. The derived solutions are much efficient to explain the several physical properties depending upon various existing arbitrary constants and functions. Moreover, some of them are more general than previously established results (Peng and Shen in Pramana 67:449–456, 2006; Malik et al. in Comput Math Appl 64:2850–2859, 2012; Zahran and Khater in Appl Math Model 40:1769–1775, 2016; Zayed and Al-Nowehy in Opt Quant Electron 49(359):1–23, 2017). In order to provide rich physical structures, the solutions are supplemented by numerical simulation, which yield some positons, negatons, kinks, wavefront, multisoliton and asymptotic nature.     

Ab initio calculations, FTIR and raman spectra of 2,3-difluorobenzonitrile.

Geometry, vibrational frequencies, atomic charges and several thermodynamic parameters (the total energy, the zero point energy, the rotational constants and the room temperature entropy) were calculated using ab initio quantum chemical methods for 2,3-difluorobenzonitrile molecule. The results were compared with experimental values. With the help of two specific scaling procedures, observed FTIR and Raman vibrational frequencies were analysed and assigned to different normal modes of the molecule. The error obtained was in general very low. Other general conclusions have also been deduced.