Growth regulation of luminescent gold nanoparticles directed from amphiphilic block copolymers:highly-controlled nanoassemblies toward tailored in-vivo transport

The understanding of amphiphilic block copolymers(ABC)in encapsulation and transport of inorganic nanomedicines is highly desired.Still,it remains limited due to the challenges in the fabrication of nanoassemblies(NAs)with highly-controlled shape and loading of nanoparticles.Herein,through growth regulation of luminescent gold nanoparticles(Au NPs)by different reductants with ABC pluronic F127 as a template,a straightforward strategy is reported for in-situ fabrication of three wellcontrolled gold NAs(Au NAs)that display tunable shapes from spherical to elongated nanostructures and controllable surface chemistry and loading of Au NPs with distinct emissions but identical individual Au NP size.The three Au NAs exhibit tailored invivo transport behaviours:those with spherical shape and more hydrophilic surface show longer blood retention with higher tumor-targeting efficiency(~25.3%injection dose/g)and excellent long-term near-infrared tumor imaging even after 96 h postinjection.These findings provide a useful guidance in designing specific nanostructures for future nanomedicine transport.     

Anisotropic Superconducting Properties of Kagome Metal CsV_3Sb_5

We systematically measure the superconducting(SC) and mixed state properties of high-quality CsV_3 Sb_5 single crystals with T_c～3.5 K.We find that the upper critical field H_(c2)(T) exhibits a large anisotropic ratio of H_(c2)~(ab)/H_(c2)~c～9 at zero temperature and fitting its temperature dependence requires a minimum two-band effective model.Moreover,the ratio of the lower critical field,H_(c1)~(ab)/H_(c1)~c,is also found to be larger than 1,which indicates that the in-plane energy dispersion is strongly renormalized near Fermi energy.Both H_(c1)(T) and SC diamagnetic signal are found to change little initially below T_c～3.5 K and then to increase abruptly upon cooling to a characteristic temperature of ～2.8 K.Furthermore,we identify a two-fold anisotropy of in-plane angular-dependent magnetoresistance in the mixed state.Interestingly,we find that,below the same characteristic T～2.8 K,the orientation of this two-fold anisotropy displays a peculiar twist by an angle of 60° characteristic of the Kagome geometry.Our results suggest an intriguing superconducting state emerging in the complex environment of Kagome lattice,which,at least,is partially driven by electron-electron correlation.     

STATCOM的控制方法研究

文章在STATCOM基本原理与模型的基础上,理论分析了STATCOM的两类控制方法:电流间接控制和电流直接控制,并且对这两种方法进行了基于TMS320F240DSP芯片的编程实现,从理论上得出不同控制方法的优缺点.     

In Vitro and In Vivo Antibacterial Activity,Toxicity and Resistance Analysis of Pleuromutilin Derivative Z33 against Methicillin-Resistant Staphylococcus aureus

The novel pleuromutilin derivative, which showed excellent in vitro antibacterial activity against MRSA, 22-(2-(2-(4-((4-(4-nitrophenyl)piperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetamido)phenyl)thioacety-l-yl-22-deoxypleuromutilin (Z33), was synthesized and characterized in our previous work. In this study, the preliminary pharmacodynamics and safety of Z33 were further evaluated. In in vitro antibacterial activity assays, Z33 was found to be a potent bactericidal antibiotic against MRSA that induced dose-dependent growth inhibition and long-term post-antibiotic effect (PAE). The drug-resistance test demonstrated that Z33 possessed a narrow mutant selection window and lower propensities to select resistance than that of tiamulin. Cytochrome P450 (CYP450) inhibition assay determined that the inhibitory effect of Z33 was similar to that of tiamulin against the activity of CYP3A4, and was lower than that of tiamulin on the activity of CYP2E1. Toxicity determination showed that both Z33 and tiamulin displayed low cytotoxicity of RAW264.7 cells. Furthermore, Z33 was found to be a high-security compound with a 50% lethal dose (LD₅₀) above 5000 mg/kg in the acute oral toxicity test in mice. In an in vivo antibacterial activity test, Z33 displayed better therapeutic effectiveness than tiamulin in the neutropenic mouse thigh infection model. In summary, Z33 was worthy of further development as a highly effective and safe antibiotic agent against MRSA infection.     

VPN介绍及其安全性问题探讨

本文简要介绍了一下VPN的发展历史及其主要技术,阐述了现在比较常见的三种VPN技术,从大体上介绍了它们的主要技术及其优缺点.重点介绍了引起人们关注的VPN安全问题.     

光声喇曼光谱中线性光声信号的影响

本文探讨了光声喇曼光谱中线性光声信号对灵敏度、探测极限和频移的影响，导出了连续和脉冲光声喇曼光诸中线性光声信号的普适表达式，进而导出了光声喇曼光谱的信噪比和探测极限，理论值与实验值基本一致     

可编程直接序列扩频通信系统的数字化实现

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数据异常值检测及修正方法研究

针对雷达测量数据中存在的异常值,对数据中的时间参数根据其变化规律的等差性进行异常值检测。对雷达发射功率、角度、距离参数异常问题,基于邻近去最值均值滤波原理,采用滑窗方式进行检测并修正。实验结果表明,提出的检测方法能够有效检测并修正数据中的异常跳变点且不改变正常值。     

激光冲击成形钛合金板料W形曲面的质量改进研究

实验以TA2钛合金板料作为试样,研究了激光冲击成形W形曲面的变形特点,分析了曲面底部产生微小鼓包的原因.为了改进成形面质量,提出了在板料与模具之间放置弹性垫,并对使用弹性垫的激光冲击成形W形曲面进行了数值模拟研究.结果表明,激光冲击与模具结合可以实现板料的W形曲面成形,W形面底部基本平整,但有微小鼓包;使用弹性垫可以抑制小鼓包的产生,能显著改善W形曲面的成形质量,使受冲击区域更加光滑.     

一种基于MRHT的航迹起始新方法研究

针对随机Hough变换法（RHT）只适应于稀疏杂波环境且最大采样次数Kmax难于选取等问题,本文提出一种改进的随机Hough变换法（MRHT）,对RHT算法加入了采样终止准则和约束条件限制。仿真实验表明,该算法与RHT相比,不仅有效的减少了虚警航迹概率,而且在计算时间方面大大减小,适于工程应用。