Photoresponsive self‐assembling structures from a pyrene‐based triblock copolymer

A new photoresponsive amphiphilic triblock copolymer, poly(pyrenylmethyl methacrylate)‐block‐polystyrene‐block‐poly(ethylene oxide) (PPy‐b‐PSt‐b‐PEO), was synthesized using atom‐transfer radical polymerization. Formation of colloidal aggregates of the polymer was observed in solutions under controlled conditions due to the amphiphilic nature of the polymer. Irradiation of the polymer aggregates using UV light resulted in the photodissociation of 1‐pyrenemethanol units from the polymer back‐bone resulting in break‐up of the aggregates mainly due to the hydrophilic nature of the residual polymer. The use of these polymer aggregates to trap hydrophobic fluorescent dyes in water and its controlled release on exposure to UV light has also been explored. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011     

用于吖内酯合成的二氧化钛纳米晶体材料PriyankaAnandgaonker,GaneshKulkarni,SureshGaikwad,AnjaliRajbhoj简

Titanium dioxide nanoparticles were prepared by a electrochemical reduction method using parameters such as current density, solvent polarity, distance between electrodes, and concentration of stabilizers to control the size of the nanoparticles. The nanoparticles were characterized by UV-Vis spectroscopy, X-ray diffraction, scanning electron microscopy and transmission electron microscopy, and their catalytic performance was tested for the synthesis of a series of 4-aryldiene-2-phenyl-5(4)-oxazolones from the cyclodehydration and condensation of the respective aldehyde, hippuric acid and acetic anhydride. Easy availability, reusability and eco-friendliness were some prominent features of the nanocrystalline titanium dioxide catalyst.     

A concise review of bioanalytical methods of small molecule immuno‐oncology drugs in cancer therapy

Immuno‐oncology (IO) is an emerging option to treat cancer malignancies. In the last two years, IO has accounted for more than 90% of the new active drugs in various therapeutic indications of oncology drug development. Bioanalytical methods used for the quantitation of various IO small molecule drugs have been summarized in this review. The most commonly used are HPLC and LC–MS/MS methods. Determination of IO drugs from biological matrices involves drug extraction from the biological matrix, which is mostly achieved by simple protein precipitation, liquid–liquid extraction and solid‐phase extraction. Subsequently, quantitation is usually achieved by LC–MS/MS, but HPLC–UV has also been employed. The bioanalytical methods reported for each drug are briefly discussed and tabulated for easy access. Our review indicates that LC–MS/MS is a versatile and reliable tool for the sensitive, rapid and robust quantitation of IO drugs.     

A viable and efficacious catalyst,CeO2/HAp,for green synthesis of novel pyrido[2,3-d]pyrimidine derivatives

Research on Chemical Intermediates - A facile one-pot green protocol at room temperature has been devised for the synthesis of novel pyrido[2,3-d]-pyrimidine derivatives catalyzed by CeO2-doped...     

N-heterocyclic carbene catalysed homoenolate addition to 3-methyl-4-nitro-5-styrylisoxazoles

We describe the development of an N-heterocyclic carbene catalysed homoenolate addition to 4-nitro-5-styrylisoxazoles to give substituted cyclopentanones with a unique substitution pattern and as single diastereoisomers. The synthetic utility of the cyclopentanones obtained was briefly explored through their conversion into α-fluorinated diketones and keto acids.