Transmission Characteristics of Multi-Soliton Train in Twin-Core Fiber

Transmission characteristics of multisoliton train are analyzed by numerical simulation in twin-core fiber. It is shown that stable transmission of multisoliton train requires some difference of initial relative phase and enough initial relative separation between input solitons under strong coupling between two cores.     

动态对抗下捷变频对雷达检测性能的影响及其抗干扰性能度量研究

分析研究了动态对抗情况下捷变频对雷达检测性能的影响,提出了一种雷达捷变频抗干扰性能的度量方法.     

BP网络过拟合现象满足的不确定关系新的改进式

类比信息传递过程中的一般测不准关系式 ,引进表征问题复杂性的函数复相关系数R和代表网络结构特性的隐节点数h ,揭示了BP网络过拟合现象出现时的网络学习能力与推广能力之间满足的不确定关系式 ;通过模拟了 12种不同类型复杂程度函数的过拟合数值试验 ,确定出关系式中的过拟合参数 p的取值范围已缩小为 1×10 -5～ 5× 10 -4;给出应用BP网络对给定样本集的训练过程中 ,判断出现过拟合现象的方法     

波面倾斜脉冲泵浦的高效可见光飞秒光参量产生和放大器

利用脉冲波面倾斜技术补偿三波相互作用的群速度失配，建立了掺钛蓝宝石飞秒再生放大器输出倍频光泵浦共线类匹配ＢＢＯ晶体的光参量产生和放大器，其信号和空闲光输出调谐范围为０．４７～２．７μｍ，脉冲宽度为１００～１７０ｆｓ，重复率为１ｋＨｚ。脉冲最大输出能量为６．５μＪ，总能量转换效率大于１５％。     

一种自组织结构的神经网络模式分类器

本文研究了一种自组织结构的神经网络模式分类器．它由一个多层网络和一个自组织机构组成．通过对训练样本的聚类分析，它能有效地构造和训练网络，并能在学习过程中自适应地调节网络结构．它具有收敛速度快，能避免局部极值点和应用方便等显著优点．计算机模拟实验证实了其优越性．     

钨硅化物砷化镓Schottky接触的形成和特性

本文报道了钨硅化物-砷化镓Schottky接触的形成过程和电学特性.实验表明,WSi_x/GaAs Schottky接触具有优越的I-V特性,势垒高度保持在0.8V,理想性因子实际上保持在1,并具有高温稳定性.研究表明,除了硅化物的成份,表面处理工艺和硅化物淀积技术也将对Schottky接触的I-V特性和热稳定性产生强烈的影响.本文提出利用对GaAs衬底的溅射腐蚀和在淀积过程中加以负的衬底偏置能显著地改进金属层与衬底的粘附性.     

Investigation of the Uptake and Transport of Two Novel Camptothecin Derivatives in Caco-2 Cell Monolayers

Irinotecan and Topotecan are two Camptothecin derivatives (CPTs) whose resistance is associated with the high expression of breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp). To reverse this resistance, two novel CPTs, FL77-28 (7-(3-Fluoro-4-methylphenyl)-10,11-methylenedioxy-20(S)-CPT) and FL77-29 (7-(4-Fluoro-3-methylphenyl)-10,11-methylenedioxy-20(S)-CPT), were synthesized by our group. In this study, the anti-tumor activities of FL77-28, FL77-29, and their parent, FL118 (10,11-methylenedioxy-20(S)-CPT), were evaluated and the results showed that FL77-28 and FL77-29 had stronger anti-tumor activities than FL118. The transport and uptake of FL118, FL77-28, and FL77-29 were investigated in Caco-2 cells for the preliminary prediction of intestinal absorption. The apparent permeability coefficient from apical to basolateral (P_{app AP-BL}) values of FL77-28 and FL77-29 were (2.32 ± 0.04) × 10⁻⁶ cm/s and (2.48 ± 0.18) × 10⁻⁶ cm/s, respectively, suggesting that the compounds had moderate absorption. Since the transport property of FL77-28 was passive diffusion and the efflux ratio (ER) was less than 2, two chemical inhibitors were added to further confirm the involvement of efflux proteins. The results showed that FL77-28 was not a substrate of P-gp or BCRP, but FL77-29 was mediated by P-gp. In conclusion, FL77-28 might be a promising candidate to overcome drug resistance induced by multiple efflux proteins.     

Detoxified pneumolysin derivative ΔA146Ply inhibits autophagy and induces apoptosis in acute myeloid leukemia cells by activating mTOR signaling

Leukemia is caused by the malignant clonal expansion of hematopoietic stem cells, and in adults, the most common type of leukemia is acute myeloid leukemia (AML). Autophagy inhibitors are often used in preclinical and clinical models in leukemia therapy. However, clinically available autophagy inhibitors and their efficacy are very limited. More effective and safer autophagy inhibitors are urgently needed for leukemia therapy. In a previous study, we showed that ΔA146Ply, a mutant of pneumolysin that lacks hemolytic activity, inhibited autophagy of triple-negative breast cancer cells by activating mannose receptor (MR) and toll-like receptor 4 (TLR4) and that tumor-bearing mice tolerated ΔA146Ply well. Whether this agent affects AML cells expressing TLR4 and MR and the related mechanisms remain to be determined. In this study, we found that ΔA146Ply inhibited autophagy and induced apoptosis in AML cells. A mechanistic study showed that ΔA146Ply inhibited autophagy by activating mammalian target of rapamycin signaling and induced apoptosis by inhibiting autophagy. ΔA146Ply also inhibited autophagy and induced apoptosis in a mouse model of AML. Furthermore, the combination of ΔA146Ply and chloroquine synergistically inhibited autophagy and induced apoptosis in vitro and in vivo. Overall, this study provides an alternative effective autophagy inhibitor that may be used for leukemia therapy.Subject terms: Translational research, Acute myeloid leukaemia     

ZnO纳米棒在Si衬底上外延生长研究

运用热蒸发ZnO粉末法,以金做催化剂,分别在Si(100)和Si(111)两种基片上外延生长了ZnO纳米棒(样品分别标为1#和2#).通过X射线衍射(XRD)和扫描电子显微镜(SEM)分析,结合ZnO与Si的晶格结构特征,从理论上得出了两个样品的晶格匹配关系.1#样品:[0001]ZnO∥[114]Si,[0001]ZnO∥[1-1-4]Si,[0001]ZnO∥[11-4]Si,[0001]ZnO∥[1-14]Si,失配度为1.54;;2#样品:[0001]ZnO∥[111]Si,[21-1-0]ZnO∥[11-0]Si,[1-21-0]ZnO∥[1-01]Si ,[1-1-20]ZnO∥[011-]Si,失配度为18.12;.研究表明Si衬底对ZnO纳米棒生长方向具有调控作用.