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排序方式: 共有140条查询结果,搜索用时 15 毫秒
31.
Aranit Harizaj Olivier Q. De Clercq Benedicte Descamps Christian Vanhove Stefaan C. De Smedt Dirk Poelman Ine Lentacker Kevin Braeckmans 《Particle & Particle Systems Characterization》2019,36(11)
Dendritic cell (DC)‐based vaccines for immunotherapy have already achieved promising results in the last decade. To further improve current treatment protocols and enhance the therapeutic outcome, noninvasive in vivo tracking of DCs remains of crucial importance. Persistent luminescent nanoparticles (PLNPs) are inorganic materials which show an afterglow for hours after the optical excitation has ceased. If the afterglow is in the near‐infrared, the emission of injected particles can be tracked in vivo. However, stability and toxicity issues limit the use of bare PLNPs for biological applications. Therefore, appropriate surface functionalization is needed to improve their biocompatibility. In this study, it is demonstrated that near‐infrared light emitting LiGa5O8:Cr3+ nanoparticles can be functionalized with a biocompatible lipid coating which provides them with outstanding stability in biological media. In vitro experiments show efficient uptake, absence of cytotoxicity even at very high particle concentrations, and no adverse effects on the maturation potential of DCs. DCs labeled with lipid‐coated LiGa5O8:Cr3+ nanoparticles injected in mice can be imaged over days, confirming efficient in vivo migration to the popliteal lymph node. Together the results show that lipid coated LiGa5O8:Cr3+ nanoparticles possess excellent possibilities for further use in research and development of DC based vaccines. 相似文献
32.
Saad Baaj Georges Skandalis Stefaan Vaes 《Communications in Mathematical Physics》2003,235(1):139-167
In this paper, we study C*-algebraic quantum groups obtained through the bicrossed product construction. Examples using groups of adeles are given and
they provide the first examples of locally compact quantum groups which are not semi-regular: the crossed product of the quantum
group acting on itself by translations does not contain any compact operator. We describe all corepresentations of these quantum
groups and the associated universal C*-algebras. On the way, we provide several remarks on C*-algebraic properties of quantum groups and their actions.
Received: 10 October 2002 / Accepted: 10 October 2002 Published online: 24 January 2003
Communicated by A. Connes 相似文献
33.
Stefaan Cottenier Veerle Vanhoof Doru Torumba Valerio Bellini Mehmet Çakmak Michel Rots 《Hyperfine Interactions》2004,158(1-4):9-18
For some years already, ab initio calculations based on Density Functional Theory (DFT) belong to the toolbox of the field of hyperfine interaction studies.
In this paper, the standard ab initio approach is schematically sketched. New features, methods and possibilities that broke through during the past few years
are listed, and their relation to the standard approach is explained. All this is illustrated by some highlights of recent
ab initio work done by the Nuclear Condensed Matter Group at the K.U.Leuven. 相似文献
34.
De Smet S Balcaen A Claeys E Boeckx P Van Cleemput O 《Rapid communications in mass spectrometry : RCM》2004,18(11):1227-1232
As part of a larger experiment, 31 young bulls, divided into three groups, were given different diets containing either C(3) plants or a combination of C(3) and C(4) plant-based feeds in three feeding periods before slaughter. Variation in the proportion of C(4) plant material in the diets was made by including or not maize or maize-derived ingredients, whereas the other dietary constituents were from C(3) plants. Analysis of stable carbon isotope ratios (delta(13)C value) was performed on different tissues taken at slaughter: blood, plasma, liver, kidney fat, hair, muscle and ruminal contents. Blood and plasma samples were also taken at the beginning of each period. A highly significant difference was found in the delta(13)C values of blood and plasma samples taken from animals that had received a diet of only C(3) plants or with 59% C(4) material for 70 days. The delta(13)C values of all different samples taken at slaughter were highly significantly different between the three feeding groups that had received diets with 0, 13.5 or 35% C(4) material for on average 137, 139 and 83 days, respectively. For the three groups, samples of hair, muscle, plasma, whole blood and liver were significantly enriched in (13)C compared with the diet (except for liver in one group), whereas kidney fat was significantly depleted. The proportion of C(4) plant material could be accurately estimated from the delta(13)C values of different tissue samples. Stable carbon analysis of different tissues from beef animals can be used to trace back diets containing variable proportions of C(3) and C(4) plant material. 相似文献
35.
Ceschia Sara Dang Nguyen De Causmaecker Patrick Haspeslagh Stefaan Schaerf Andrea 《Annals of Operations Research》2019,274(1-2):171-186
Annals of Operations Research - This paper reports on the Second International Nurse Rostering Competition (INRC-II). Its contributions are (1) a new problem formulation which, differently from... 相似文献
36.
37.
Filipe Camargo Dalmatti Alves Lima Rafael Rodrigues do Nascimento Marcos Brown Gon?alves Stefaan Cottenier Marília Junqueira Caldas Helena Maria Petrilli 《Hyperfine Interactions》2010,197(1-3):23-27
We compare published TDPAC experiments on 111Cd in the crown thioether C6H12S3AgCl with ab-initio electronic structure calculations performed within the framework of the Density Functional Theory using the Projector Augmented Wave method. We conclude from this comparison that the Cd atom at the very moment of the TDPAC experiment is positively charged, and we point out to a methodological difference between reproducing experimental electric-field gradients in molecules versus solid metals. 相似文献
38.
Frank van de Manakker Kevin Braeckmans Najim el Morabit Stefaan C. De Smedt Cornelus F. van Nostrum Wim E. Hennink 《Advanced functional materials》2009,19(18):2992-3001
This paper reports on the degradation and protein release behavior of a self‐assembled hydrogel system composed of β‐cyclodextrin‐ (βCD) and cholesterol‐derivatized 8‐arm star‐shaped poly(ethylene glycol) (PEG8). By mixing βCD‐ and cholesterol‐derivatized PEG8 (molecular weights 10, 20 and 40 kDa) in aqueous solution, hydrogels with different rheological properties are formed. It is shown that hydrogel degradation is mainly the result of surface erosion, which depends on the network swelling stresses and initial crosslink density of the gels. This degradation mechanism, which is hardly observed for other water‐absorbing polymer networks, leads to a quantitative and nearly zero‐order release of entrapped proteins. This system therefore offers great potential for protein delivery. 相似文献
39.
Jozef Škorupa Jürgen Slowack Stefaan Mys Nikos Deligiannis Jan De Cock Peter Lambert Adrian Munteanu Rik Van de Walle 《Signal Processing: Image Communication》2010,25(9):674-686
Aiming for low-complexity encoding, video coders based on Wyner–Ziv theory are still unsuccessfully trying to match the performance of predictive video coders. One of the most important factors concerning the coding performance of distributed coders is modeling and estimating the correlation between the original video signal and its temporal prediction generated at the decoder.One of the problems of the state-of-the-art correlation estimators is that their performance is not consistent across a wide range of video content and different coding settings. To address this problem we have developed a correlation model able to adapt to changes in the content and the coding parameters by exploiting the spatial correlation of the video signal and the quantization distortion.In this paper we describe our model and present experiments showing that our model provides average bit rate gains of up to 12% and average PSNR gains of up to 0.5 dB when compared to the state-of-the-art models. The experiments suggest that the performance of distributed coders can be significantly improved by taking video content and coding parameters into account. 相似文献