Small Iminocoumarin Derivatives as Red Emitters: From Biological Imaging to Highly Photoluminescent Non‐doped Micro‐ and Nanofibres

The fluorescence properties of four derivatives of 3‐thienyl‐2‐(N‐dicyanovinyl)iminocoumarin, bearing a diethylamino group in the 7‐position or a methoxy group in the 6, 7 and 8 positions, were compared in solution and in the solid state. The 7‐diethylamino derivative was strongly fluorescent in various solvents, with marked solvatochromism. Its fluorescence was quenched by aggregation. In contrast, the methoxy derivatives were only moderately or weakly fluorescent in solution, but two of them were strongly photoluminescent in the crystalline state, owing to favourable molecular packing. The 6‐methoxy derivative even exhibited spectacular crystallization‐enhanced emission, examples of which are particularly rare for this type of dyes. Dyes were tested for biological use. The 7‐diethylamino derivative led to particularly strong fluorescence staining of the cytoplasm of HCT‐116 colon cancer cells. No fading was observed over prolonged illumination by the microscope light beam, but a phototoxic effect was detected. The use of the dyes as red‐emitting materials was also investigated. Using easy‐to‐implement preparation methods, the compounds self‐ assembled to give one‐dimensional nano‐ and microsized particles, including millimeter‐long microfibres that exhibited clear wave‐guiding properties. This study shows the value of these low molecular‐weight molecules for the preparation of new orange and red‐emitting fluorescent materials based on totally pure dye.     

Time marching for simulation of fluid–structure interaction problems

Numerical simulation of industrial multi-physics problems is still a challenge. It generally requires large computational resources. It may involve complex code coupling techniques. It also relies on appropriate numerical methods making data transfer possible, quick and accurate. In the framework of partitioned procedures, multi-physics computations require the right choice of code coupling schemes, because several physical mechanisms are involved. Numerical simulation of fluid–structure interactions is one of these issues. It is investigated in this paper. First the computational process involving a code coupling procedure is presented. Then, applications and test cases involving fluid structure interactions are investigated using several examples. A partitioned procedure involves several operators ensuring code coupling. A special attention must be paid to energy conservation at the fluid–structure interface, especially when it is moving and when strong non-linear behaviour occurs in both fluid and structure systems. In the present work, several fluid–structure code-coupling schemes are compared and discussed in terms of stability and energy conservation properties. The criteria are based on the evaluation of the energy that is numerically created at the fluid–structure interface. This is achieved by considering the staggering process due to the time lag between the fluid and structure solvers. Comparisons are made, and finally the article gives recommendations for creating a tool devoted to coupled simulations of fluid structure interactions.     

Some computations of stable twisted homology for mapping class groups

Abstract

In this paper, we deal with stable homology computations with twisted coefficients for mapping class groups of surfaces and of 3-manifolds, automorphism groups of free groups with boundaries and automorphism groups of certain right-angled Artin groups. On the one hand, the computations are led using semidirect product structures arising naturally from these groups. On the other hand, we compute the stable homology with twisted coefficients by FI-modules. This notably uses a decomposition result of the stable homology with twisted coefficients for pre-braided monoidal categories proved in this paper.

Communicated by Jason P. Bell     

DNA-Intercalative Platinum Anticancer Complexes Photoactivated by Visible Light

Photoactivatable agents offer the prospect of highly selective cancer therapy with low side effects and novel mechanisms of action that can combat current drug resistance. 1,8-Naphthalimides with their extended π system can behave as light-harvesting groups, fluorescent probes and DNA intercalators. We conjugated N-(carboxymethyl)-1,8-naphthalimide (gly-R-Nap) with an R substituent on the naphthyl group to photoactive diazido Pt^IV complexes to form t,t,t-[Pt(py)₂(N₃)₂(OH)(gly-R-Nap)], R=H ( 1 ), 3-NO₂ ( 2 ) or 4-NMe₂ ( 3 ). They show enhanced photo-oxidation, cellular accumulation and promising photo-cytotoxicity in human A2780 ovarian, A549 lung and PC3 prostate cancer cells with visible light activation, and low dark cytotoxicity. Complexes 1 and 2 exhibit pre-intercalation into DNA, resulting in enhanced photo-induced DNA crosslinking. Complex 3 has a red-shifted absorption band at 450 nm, allowing photoactivation and photo-cytotoxicity with green light.     

10 Gbit/s high performance MQW tandem modulator for solitongeneration and coding

Soliton generation and coding are obtained using a novel, and simple tandem integrated electroabsorption (EA) MQW modulator structure. Negligible electrical crosstalk (<40 dB) is obtained due to the integration between the modulators, of an optical amplifier based on the same active layer. This also allowed a very low fibre to fibre insertion loss of 9 dB. The device was operated at 10 Gbit/s     

Effet elastique en volume dans le nickel irradie aux electrons a tres basse temperature

Abstract

Experiments designed to determine the damage distribution produced by energetic heavy ions in Si are described. For low ion doses (10¹¹ to 10¹³ cm^?2), the location of the damage peak was determined by changes, which were produced by ion damage, in the electrical properties of thin (0.6 μ), uniformly doped Si layers as a function of depth. The ratio of the peak position in the damage distribution to the peak position in the ion distribution was determined to be approximately 0.6 ± 0.1 for Si²⁹ (150 keV), P³¹ (70, 140, 200 keV), B¹¹ (60 keV), and As⁷⁵ (280 keV). A comparison of carrier removal rates and the number of displaced lattice atoms previously reported from back-scattering experiments with He ions indicates that the nature of damage produced by Si²⁹ and B¹¹ are different. In the former case, cluster damage (amorphous disordered regions) appears to be an important form of radiation damage, while in the latter case, isolated defects are the dominant form of radiation damage for room temperature implantations. Isochronal annealing studies of Si²⁹ and B¹¹ ion damage provide further support for the different nature of radiation defects produced by these species. For high doses (10¹⁴ to 10¹⁶ cm^?2), the growth of a continuous amorphous Si layer was studied with ESR, optical transmission, and visual observation and stripping studies. The ratio of the location of the damage peak to that of the peak ion concentration was determined to be approximately 0.7 for P³¹ (140, 280 keV) and 0.8 for As⁷⁵ (280 keV). From the ESR studies, the number of displaced atoms in amorphous clusters was estimated to be 2800 per 280 keV P³¹ ion.     

Electron paramagnetic resonance: Nonlinear least-squares fitting of the Hamiltonian parameters from powder spectra with the Levenberg-Marquardt algorithm

In many instances, the deduction of spectroscopic parameters from electron paramagnetic resonance spectra depends on spectrum simulation and parameter optimization. We have developed two software packages based on the approximate formulae of Iwasaki for the calculation of line positions and on the Levenberg-Marquardt algorithm for nonlinear least-squares optimization. Our software applies to systems having an anisotropicg-tensor and an arbitrary number of hyperfine interactions with nuclei. They are written in the FORTRAN 77 programming language. At present, neither the nuclear quadrupolar interaction nor the nuclear Zeeman interaction terms are handled. The programs CRISAJU and EPRPOWDERFIT apply to the cases of single crystals and powders, respectively. For use in the latter, thanks to the software ODYSSEE which implements automatic differentiation of algorithms, an ancillary subroutine, which contributes to the performance of the optimization, was created automatically.     

Base-promoted ruthenium carbonyl cluster complexes: From fundamental reactions to catalysis

An attempt to establish a link between the rich chemistry of ruthenium carbonyl clusters doped by nucleophilic anions, and the known effect of promoters in some ruthenium-based catalytic processes.