氨基甲酸酯类化合物的合成方法改进

将Alper羰基化合成氨基甲酸酯的实验改在高压釜中进行 ,并且充入的气体量只比化学量稍过量 ,在没有盐酸或Lewis酸的作用下 ,伯胺和仲胺都得到了非常高的转化率和非常高的选择性 ,特别仲胺的转化率和选择性比文献报道有很大提高。     

Improving imprinted shape cavities of molecularly imprinted sol–gel host matrix with minimal relaxation for sensing of creatinine

Journal of Sol-Gel Science and Technology - Molecularly imprinted polymer (MIP) is of great attention in biomimetic recognition systems due to its selective molecular recognition towards any guest...     

Structural,Spectroscopic and Thermal Analysis of Cocrystals of Carbamazepine and Piracetam with Hydroquinone

Abstract  

Cocrystals of two important active pharmaceutical ingredients, carbamazepine and piracetam, with hydroquinone are reported. Cocrystal formation between the selected APIs and hydroquinone is investigated with the aid of solid-state grinding methods. Both the crystal structures belong to the triclinic, P [`1]P \bar{1} space group, with the cocrystal involving carbamazepine and hydroquinone having the unit cell parameters a = 6.9725 (14) ?, b = 8.8175 (18) ?, c = 15.083 (3) ?, α = 106.96 (3)°, β = 92.16 (3)°, γ = 103.23 (3)°, V = 858.0 (4) ?³ and Z = 2; and the cocrystal involving piracetam and hydroquinone has the unit cell parameters a = 6.4909 (13) ?, b = 6.5410 (13) ?, c = 11.612 (2) ?, α = 103.92 (3)°, β = 104.53 (3)°, γ = 91.06 (3)°, V = 461.59 (18) ?³ and Z = 2. Analysis of the cocrystals revealed that they are sustained by an alcohol–carboxamide heterosynthon. In addition, the cocrystal of carbamazepine and hydroquinone features an amide–alcohol heterosynthon and an alcohol–alcohol homosynthon. The cocrystal of piracetam and hydroquinone features an amide–amide dimer synthon. Cocrystal formation was evidenced from the shifts in the vibrational frequencies corresponding to the functional groups present on the cocrystal components.     

Preparation of hierarchical polyaniline nanotubes based on self‐assembly and its electrochemical capacitance

This article reports the preparation and self‐assembly of polyaniline (PANI) nanotubes, which were chemically synthesized by using in situ doping polymerization in the presence of ammonium persulfate (APS; (NH₄)S₂O₈) as the oxidant without the use of an external template. The synthesized hierarchically nanotubes with a shape of a single nanotube with a length of 0.6 to 0.8 µm and an average with of 100 nm assembled from nanoparticles. The effects of the [salicylic acid]/[aniline] ratio on the size and capacitance of PANI nanotubes were studied. The specific capacitance behavior of the PANI nanotubes was also investigated by using cyclic voltammogram and galvanostatic charge–discharge tests. A maximum discharge‐specific capacitance of 422.5 F/g could be achieved, suggesting its potential application in electrode material for electrochemical capacitors. Copyright © 2011 John Wiley & Sons, Ltd.     

Synthesis and characterization of chemically anchored adenosine with PHEMA grafted gold nanoparticles

The synthesis of chemically anchored adenosine with biocompatible poly(2-hydroxylethyl methacrylate) grafted gold nanoparticles (Ado-i-PHEMA-g-AuNPs) was realized by employing a simple strategy. Disulfide-containing poly(2-hydroxylethyl methacrylate) (DT-PHEMA) was initially synthesized by atom transfer radical polymerization (ATRP). The formation of DT-PHEMA was confirmed by ¹H-NMR and FT-IR. The molecular weight and molecular weight distribution were found to be 9.6 kg/mol and 1.40 from GPC analysis. DT-PHEMA was subsequently used for the synthesis of PHEMA-g-AuNPs by a grafting to protocol. The grafting of DT-PHEMA on the surface of AuNPs was confirmed by FT-IR, TGA, XPS, and EDX analyses. The particle size of the PHEMA-g-AuNPs was found to be ca. 5.0 nm from HR-TEM analysis. Boronic acid was used for functionalization of PHEMA-g-AuNPs, which was then subjected for covalent immobilization with adenosine via strong interaction between free hydroxyl groups of adenosine and boronic acid. Characterization and properties of the Ado-i-PHEMA-g-AuNPs were investigated by taking advantage from FT-IR, XPS, EDX, and UV-visible spectroscopy. The Ado-i-PHEMA-g-AuNPs nanocomposite exhibits a surface plasmon resonance peak at 586 nm which is red shifted from AuNPs (521 nm), indicating significant changes of surface property upon PHEMA-adenosine immobilization onto the surface of AuNPs.     

Microcalorimetric study of the effect of artesunate on the growth metabolism of mitochondria isolated from rat liver

In this study, the metabolic thermogenic curves of mitochondria isolated from rat liver tissue were drawn, and the effects of artesunate on metabolic activity of mitochondria were studied using TAM Air Isothermal Microcalorimeter. After isolation from the rat liver, mitochondria still have metabolic activity and can live for a week with appropriate nutrients. With the addition of artesunate (7.5 μM/mL), the metabolic activity of mitochondria was completely lost at this concentration. From the thermogenic curves, we obtained the thermokinetic equations under different conditions: T _max = 2512.24 + 1761.53c, R = 0.9375; and Tlag (min) = 707.26 + 285.17c, R = 0.9846. The results showed that artesunate was a mitochondria-targeted drug having obvious effects on mitochondrial metabolism.     

Structure determination of selaginellins G and H from Selaginella pulvinata by NMR spectroscopy

Selaginellins G ( 1 ) and H ( 2 ), two new selaginellin derivatives, were isolated from the whole plant of Selaginella pulvinata. Their structures were elucidated, and complete assignments of the ¹H and ¹³C NMR spectroscopic data were achieved by 1D and 2D NMR experiments (HSQC, HMBC, COSY and ROESY). Compound 1 displayed good antifungal activity against Candida albicans with an IC₅₀ value of 5.3 µg/ml. Copyright © 2010 John Wiley & Sons, Ltd.