Heavy neutral gauge bosons at the LHC in an extended MSSM

Searching for heavy neutral gauge bosons Z^′$Z^{\prime }$, predicted in extensions of the Standard Model based on a U(1)^′$\mathrm{U}{(1)}^{\prime }$ gauge symmetry, is one of the challenging objectives of the experiments carried out at the Large Hadron Collider. In this paper, we study Z^′$Z^{\prime }$ phenomenology at hadron colliders according to several U(1)^′$\mathrm{U}{(1)}^{\prime }$-based models and in the Sequential Standard Model. In particular, possible Z^′$Z^{\prime }$ decays into supersymmetric particles are included, in addition to the Standard Model modes so far investigated. We point out the impact of the U(1)^′$\mathrm{U}{(1)}^{\prime }$ group on the MSSM spectrum and, for a better understanding, we consider a few benchmarks points in the parameter space. We account for the D-term contribution, due to the breaking of U(1)^′$\mathrm{U}{(1)}^{\prime }$, to slepton and squark masses and investigate its effect on Z^′$Z^{\prime }$ decays into sfermions. Results on branching ratios and cross sections are presented, as a function of the MSSM and U(1)^′$\mathrm{U}{(1)}^{\prime }$ parameters, which are varied within suitable ranges. We pay special attention to final states with leptons and missing energy and make predictions on the number of events with sparticle production in Z^′$Z^{\prime }$ decays, for a few values of integrated luminosity and centre-of-mass energy of the LHC.     

Design and characterization of a 10-Gb/s dual-drive Z-cut Ti:LiNbO/sub 3/ electrooptical modulator

The design and characterization of a dual-drive (DD) Z-cut Ti:LiNbO/sub 3/ electrooptical modulator are presented. Both the radio frequency (RF) electrode layout and the optical splitters and combiners of the Mach-Zehnder interferometer are investigated: The former is designed to avoid RF line crosstalk, whereas the latter is to obtain a low-loss longitudinally short splitter structure, able to properly separate the interferometer straight optical waveguide sections. First, the RF analysis is addressed, simulating the small-signal behavior of the DD coplanar waveguide electrode structure as a function of the central ground width. The performances of different splitter layouts (circular segment bends, sin-bends, and offset bends) are then investigated using the beam propagation method. Finally, experimental results on the electrical and optical test pattern structures, and of the DD Z-cut complete modulator, are discussed and compared with simulations.     

Unbroadened-spectrum chirped Modulation: effects of the chirp-inducing mechanism on the spectral broadening in LiNbO/sub 3/ Modulators

The spectrum of a chirped optical nonreturn-to-zero data stream obtained by an external Mach-Zehnder modulator (MZM) is analyzed. We demonstrate that it is possible to induce chirp without broadening the optical spectrum by employing an MZM with optical power unbalancing in the two waveguides. For standard chirped MZMs (different electric fields on the two arms), such as z-cut LiNbO/sub 3/ modulators, the broadening as a function of chirp factor is measured for comparison.     

A Quantitative Relaxometric Version of the ELISA Test for the Measurement of Cell Surface Biomarkers

Quantitative measurement of marker expression in diseased cells is still a topic of considerable interest and different methodologies are currently under intense scrutiny. This work aims at developing an in vitro diagnostic method based on the release of paramagnetic species from relaxometrically “silent” liposomes operated by the action of a phospholipase A₂ (PLA₂) previously targeted to the epitope of interest. The released paramagnetic species causes an increase of the longitudinal water proton relaxation rate proportional to the number of PLA₂ bound to the cell outer surface. The sensitivity of the herein proposed method, named R‐ELISA, was attempted in the detection of folate receptor expression on human ovarian cancer cells by functionalizing PLA₂ with folic acid. Receptor/cell number of 8.3×10⁵ has been measured on IGROV‐1 cells. The R‐ELISA assay can detect nanomolar cell suspension receptor concentrations and has been validated by well‐established spectrofluorimetric procedures.     

Finite element and finite volume‐element simulation of pseudo‐ECGs and cardiac alternans

In this paper, we are interested in the spatio‐temporal dynamics of the transmembrane potential in paced isotropic and anisotropic cardiac tissues. In particular, we observe a specific precursor of cardiac arrhythmias that is the presence of alternans in the action potential duration. The underlying mathematical model consists of a reaction–diffusion system describing the propagation of the electric potential and the nonlinear interaction with ionic gating variables. Either conforming piecewise continuous finite elements or a finite volume‐element scheme are employed for the spatial discretization of all fields, whereas operator splitting strategies of first and second order are used for the time integration. We also describe an efficient mechanism to compute pseudo‐ECG signals, and we analyze restitution curves and alternans patterns for physiological and pathological cardiac rhythms. Copyright © 2014 John Wiley & Sons, Ltd.     

Toward milk speciation through the monitoring of casein proteotypic peptides

The possibility of detecting extraneous milk in singles species cheese‐milk has been explored. A mass spectrometry (MS)‐based procedure has been developed to detect 'signature peptides', corresponding to the predefined subset of 'proteotypic peptides', as matchless analytical surrogates of the parent caseins. Tryptic digests of skimmed milk samples from four species were analyzed by matrix‐assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF) MS. Amongst the candidate signature peptides that are able to differentiate milks from the four species, the α_s1‐casein (CN) f8‐22 peptide was selected as a convenient marker for bovine, ovine and water buffalo milk while the f4‐22 peptide was selected as a marker for the two caprine α_s1‐CN A and B variants, which differ by a Pro¹⁶ (B)‐>Leu¹⁶ (A) substitution. MALDI analysis of the digest allowed the detection of α_s1‐CN f8‐22 and caprine α_s1‐CN f4‐22. The accurate evaluation of caprine milk in a quaternary mixture required the development of a liquid chromatography/electrospray ionization (LC/ESI)‐MS procedure. Five synthetic signature peptide analogues, which differed from their natural counterparts by a single amino acid substitution, were used as internal standards to quantify the α_s1‐CN, which was chosen as a reference milk protein, from the different species. The limits of detection were 0.5% (1% for caprine) for either the MALDI or the LC/ESI‐MS method. The isotopic‐label‐free quantification of isoform‐ or variant‐specific signature peptides has disclosed a convenient approach for targeting proteins in complex mixtures. Copyright © 2010 John Wiley & Sons, Ltd.     

Structural evidence of differential forms of nanosponges of beta-cyclodextrin and its effect on solubilization of a model drug

Nanosponges (NS) are a recently developed class of hyper-branched polymers, nano-structured to form three dimensional meshwork; obtained by reacting cyclodextrins with a cross linker like diphenyl carbonate. Herein, we report an anomalous behavior of NS with regards to physical and morphological characteristics and drug encapsulation behavior by minor synthetic modification. Two distinct forms viz. crystalline and para-crystalline of NS were identified and extensively characterized by use of high resolution transmission electron microscopy (HR-TEM), X-ray powder diffraction (XRPD), scanning electron microscope, atomic force microscope, optical microscope and Fourier transform infra-red attenuated total reflectance spectroscopy (FTIR-ATR). Dimension of the crystal lattice was found to be equal to 0.61 nm. Higher magnifications clearly showed a zone axis with a hexagonal symmetry as that of beta-cyclodextrin. XRPD patterns were in concurrence with the HR-TEM results. Solubility studies with a model drug dexamethasone (DEX) showed more than three folds increase in the solubility of the drug in the crystalline NS as compared to the para-crystalline ones. Percent drug association and drug loading for DEX was found to be higher in the crystalline type of NS. An In vitro drug kinetic study evidenced a faster release of DEX from the crystalline type NS. The particle sizes of the formulations were as follows: crystalline NS: 688.6 ± 38.0 nm, para-crystalline NS: 702.2 ± 21.2 nm with polydispersity indices of 0.155 and 0.132; zeta-potential of ?26.55 ± 1.7 and ?23.42 ± 2.1 respectively. Differential scanning calorimetry and thermogravimetric analysis revealed that both forms encapsulated the drug satisfactorily. FTIR-ATR and Raman spectroscopy showed weak interactions. Crystallinity of NS was thus found to be an important factor in solubilization, in vitro kinetics and encapsulation behavior and can be tuned to give a tailored drug release profile or formulation characteristics.     

Interplay of fractionated crystallization and morphology in polypropylene/poly(ϵ‐caprolactone) blends

The thermal behavior of melt‐mixed polypropylene (PP)/poly(?‐caprolactone) (PCL) blends was investigated with differential scanning calorimetry, and it was quantitatively related to the morphology observed through scanning electron microscopy. The PP/PCL blends were immiscible in the whole composition range; however, some interesting phenomena were found. Blends with low PP contents crystallized in a fractionated fashion. By applying a self‐nucleation procedure, we demonstrated that this occurred because of a lack of highly active heterogeneities within the confined PP domains. On the other hand, PP acted as a nucleating agent for PCL, and when the PP content was reduced, the higher surface/volume ratio increased its nucleating activity. The nucleating effect was improved when the PP was self‐nucleated because of the better nucleating effect of PP annealed crystals. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 1365–1379, 2007     

A Quantitative Version of a de Bruijn-Post Theorem

A theorem due to de Bruijn and Post states that if a real valued function f defined on [0, 1] is not Riemann-integrable, then there exists a uniformly distributed sequence { x_i} such that the averages do not admit a limit. In this paper we will prove a quantitative version of this result and we will extend it to functions with values in ℝ^d.