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31.
Lirong Guo Qing Gao Jieqiong Zhu Xiaobao Jin Hui Yin Tao Liu 《Molecules (Basel, Switzerland)》2022,27(9)
Commonly used clinical chemotherapy drugs, such as cyclophosphamide (CTX), may cause injury to the ovaries. Hormone therapies can reduce the ovarian injury risk; however, they do not achieve the desired effect and have obvious side effects. Therefore, it is necessary to find a potential therapeutic candidate for ovarian injury after chemotherapy. N-Benzyl docosahexaenamide (NB-DHA) is a docosahexaenoic acid derivative. It was recently identified as the specific macamide with a high degree of unsaturation in maca (Lepidium meyenii). In this study, the purified NB-DHA was administered intragastrically to the mice with CTX-induced ovarian injury at three dose levels. Blood and tissue samples were collected to assess the regulation of NB-DHA on ovarian function. The results indicated that NB-DHA was effective in improving the disorder of estrous cycle, and the CTX+NB-H group can be recovered to normal levels. NB-DHA also significantly increased the number of primordial follicles, especially in the CTX+NB-M and CTX+NB-H groups. Follicle-stimulating hormone and luteinizing hormone levels in all treatment groups and estradiol levels in the CTX+NB-H group returned to normal. mRNA expression of ovarian development-related genes was positive regulated. The proportion of granulosa cell apoptosis decreased significantly, especially in the CTX+NB-H group. The expression of anti-Müllerian hormone and follicle-stimulating hormone receptor significantly increased in ovarian tissues after NB-DHA treatment. NB-DHA may be a promising agent for treating ovarian injury. 相似文献
32.
Xia Ren Jiaying Xiong Lingzhi Liang Yin Chen Guisen Zhang 《Molecules (Basel, Switzerland)》2022,27(9)
Here, we explored the possible interaction between duloxetine and SEP-363856 (SEP-856) in depression-related reactions. The results showed that oral administration of duloxetine showed powerful antidepressant-like effects in both the forced swimming test (FST) and the suspension tail test (TST). SEP-856 orally administered alone also exerted an antidepressant-like effect in FST and TST, especially at doses of 0.3, 1, and 10 mg/kg. In addition, duloxetine (15 mg/kg) and SEP-856 (15 mg/kg) both showed antidepressant-like effects in the sucrose preference test (SPT). Most importantly, in the above experiments, compared with duloxetine alone, the simultaneous use of duloxetine and SEP-856 caused a more significant antidepressant-like effect. It is worth noting that doses of drug combination in FST and TST did not change the motor activities of mice in the open-field test (OFT). Thus, duloxetine and SEP-856 seem to play a synergistic role in regulating depression-related behaviors and might be beneficial for refractory depression. 相似文献
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DABCO-catalyzed dimerization of Morita–Baylis–Hillman acetates to synthesize a series of 3-alkyl-4-(E)-alkenyl-cyclohex-1-ene-1,4-dicarbonyl compounds in excellent yields with modest to excellent diastereoselectivity is reported. A plausible reaction mechanism is also proposed on the basis of previous literature and preliminary investigation the asymmetric version of the reaction. 相似文献
35.
A common location of sporadic, usually unpredictable, premature failures of both SnPb and Pb-free solder joints is within the intermetallic bond to one of the contact pads. Cu pads tend to be less prone to such defects than Ni/Au coated pads, but one phenomenon is a cause of growing concern for high reliability applications. Sporadic intermetallic problems are notoriously difficult to screen for, but at least a number of them are detectable right after assembly. However, the occasional formation of a network of voids within the Cu3Sn layer forming when soldering to Cu pads is rarely noticeable until much later. To make matters worse, efforts to establish practical engineering tests for purposes of identification and screening have usually not been successful.The root cause of the so-called ‘Kirkendall voiding’ has been shown to be associated with the quality of the electroplated Cu, apparently as determined by the incorporation of minute amounts of specific organic impurities. The present work describes and discusses a series of potential tests that allow the sorting of electroplated Cu in terms of its propensity for Cu3Sn voiding during soldering and subsequent aging. The times and efforts involved in these tests differ greatly, as do their effectiveness and accuracy. Individual tests may therefore be useful at various stages from supplier qualification to monitoring of batch to batch variations. 相似文献
36.
Cong Deng Yan Yang Meng Gao Yan-Ping Zhu An-Xin Wu Jun-Rui Ma Guo-Dong Yin 《Tetrahedron》2012,68(20):3828-3834
2-Methylthio-substituted 1,4-enediones, obtained from readily available aryl methyl ketones, were reacted with primary or secondary amines to afford the desired 1,4-diaryl-2-aminobut-2-ene-1,4-diones in excellent yields with high Z/E-stereoselectivity. 相似文献
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