Recent advances in single-molecule detection on micro- and nano-fluidic devices

Single-molecule detection (SMD) allows static and dynamic heterogeneities from seemingly equal molecules to be revealed in the studies of molecular structures and intra- and inter-molecular interactions. Micro- and nanometer-sized structures, including channels, chambers, droplets, etc., in microfluidic and nanofluidic devices allow diffusion-controlled reactions to be accelerated and provide high signal-to-noise ratio for optical signals. These two active research frontiers have been combined to provide unprecedented capabilities for chemical and biological studies. This review summarizes the advances of SMD performed on microfluidic and nanofluidic devices published in the past five years. The latest developments on optical SMD methods, microfluidic SMD platforms, and on-chip SMD applications are discussed herein and future development directions are also envisioned.     

Nitrogen and boron co-doped graphene nanoribbons as peroxidase-mimicking nanozymes for enhanced biosensing

The rational design of nanozymes with superior activities is essential for improving bioassay performances. Herein, nitrogen and boron co-doped graphene nanoribbons(NB-GNRs) are prepared by a hydrothermal method using urea as the nitrogen source and boric acid as the boron source, respectively.The introduction of co-doped and edge structures provides high defects and active sites. The resultant NB-GNRs nanozymes show superior peroxidase-like activities to nitrogen-doped and boron-doped counterpa...     

Synthesis and properties of DNA complexes containing 2,2,6,6-tetramethyl-1-piperidinoxy (TEMPO) moieties as organic radical battery materials

We report here the first example of organic radical battery with DNA. Though there is a growing interest in DNA/cationic-lipid complexes as promising gene delivery vehicles, few efforts have been focused on the use of such complexes as advanced materials for organic optoelectronic applications. The present article describes how substitution of the sodium counter cation of DNA with cationic amphiphilic lipid(1-4) provided novel DNA-lipid complexes that contain TEMPO radicals, in which the actual mole ratio of phosphate to lipid was 1:0.84 to 1:0.16. All the TEMPO-containing DNA-lipid complexes displayed reversible two-stage charge/discharge processes, the discharge capacities of which were 40.5-60.0 A h kg(-1). In particular, the capacity of a DNA-lipid(3)-based cell reached 60.0 A h kg(-1), which corresponds to 192 % relative to its theoretical value for the single-electron one-stage process, indicating a two-electron process.     

用激光感生荧光法测量亚稳态原子寿命

本文用激光感生荧光法(LIF)分析了Gd原子亚稳态能级215cm~(-1),533cm~(-1),999cm~(-1)在原子束中的速度分布。由原子束轴线上两不同点上的亚稳态原子速度分布的变化得到了亚稳态原子的寿命。理论分析和实验结果表明这是一种简单、灵敏并且有效的亚稳态原子寿命测量方法。     

DYNAMICS of H+2 in TWO-COLOR ULTRASHORT LASER PULSE

Numerical simulations of ionization and dissociation processes of hydrogen molecular ion H₂⁺ interacting with two-color intense ( 10¹⁴W/cm²-10¹⁵W/cm²) ultrashort (the duration ≈ 22fs) laser pulse are made. The result shows that the ionization and dissociation processes are strongly dependent upon the relative phase between the two color fields. It means that, in the case of ultrashort pulse, the phase coherence control of ionization and dissociation processes can be realized.     

基于折线采样的高分辨率成像系统设计

针对现有的提高线阵电荷耦合器件(CCD)成像系统的图像空间分辨率的方法存在的不足,提出了一种新的采样模式,并设计了一种高分辨率成像系统。该系统利用两个相同的线阵CCD相机进行特定的空间排列,即使得相机1和相机2的CCD阵列都倾斜θ来进行扫描取像,并利用图像校正和像素插值等图像重建方法,得到高分辨率的图像。实验结果表明,倾斜角取60°的情况下,相对于单个线阵相机在θ=0°的正常采样模式下得到的采样图像,图像的空间分辨率提高了1倍,且保持了成像的视野不变。本系统工程上实现简单,十分经济且便于维护,仅利用现有的成像装置即可获取更高分辨率的图像。     

Structures and stabilities of the donor–acceptor complexes HXPY (X=Al,B; Y=H,F, OH)

The optimized geometries, complexation energies, etc. of HXPY (X?=?Al, B; Y?=?H, F, OH) donor–acceptor complexes have been investigated at the B3LYP/6-311+G(d,p), MP2/6-311+G(d,p) and/or CCSD(T)/6-311+G(d,p) levels. The results show that HBPY (Y?=?H, F, OH) is more stable than the corresponding HAlPY (Y?=?H, F, OH), F (or OH) substitution on phosphorus results in decreasing complex stability, and the stronger the electron-attracting nature of the substitution atom, the more stable the complex. Moreover, the thermodynamic and kinetic properties of the formation reaction of these donor–acceptor complexes were also examined within the temperature range 200–800?K using the general statistical thermodynamics and Eyring transition state theory with Wigner correction. It is concluded that the formation of HBPY is thermodynamically favoured over that of the corresponding HAlPY, especially at low temperature, and is kinetically favoured over that of the relevant HAlPY (Y?=?H, F, OH), especially at high temperature.     

基于NbN，AIN技术的体声波器件研究

体声波滤波器由于其低插损、小尺寸、高带外抑制等特性，随着第三代移动通信以及蓝牙技术的发展而得到广泛研究，而MEMS技术和压电薄膜制备技术的进一步发展使高性能的体声波滤波器制作成为可能．我们以单晶MgO作为器件衬底，MgO/NbN多层结构作为AIN薄膜体声波器件的反射器，NBN／AIN／NbN三层结构为谐振器．在这样的多层结构的设计中由于各种材料之间的晶格失配小，可以获得从几十纳米到几百纳米厚度不等的单晶AIN薄膜．通过控制AIN薄膜和NbN薄膜的不同厚度，可以获得不同频段范围的谐振器．压电薄膜的质量，以及体声波在多层结构界面上的能量损耗，直接影响到谐振器电学性能．基于AIN材料的压电性能，设计了NBN／AIN／NBN三层结构的谐振器，并进行了数值模拟．     

多源共蒸发制备高性能REBa2Cu3O7-x涂层导体的进展与展望

REBa2Cu3O7-x (RE：钇、钆等稀土元素,REBCO）高温超导体因其具备较高的不可逆场和上临界场等优越性能,一经发现就备受关注。但由于材料本身固有的陶瓷性及弱连接等属性,导致其实际应用起来难度较大。目前,人们已经发展了诸多制备工艺来克服这些困难,实现了REBCO超导体的实际应用。按照前驱膜沉积方法可将REBCO超导薄膜的制备分为物理法和化学法。本文综述了物理气相沉积（PVD-Physical Vapor Deposition）法中多源共蒸发法制备REBCO超导薄膜的技术起源及演变历程,并与金属有机沉积、金属有机化学气相沉积、脉冲激光沉积等不同方法生产的REBCO超导带材进行对比,突出多源共蒸发法制备的REBCO薄膜性能优异、在商业化生产效率上具有更大的优势。最后对多源共蒸发法制备REBCO超导薄膜进行总结及展望,解决多源共蒸发沉积制备REBCO薄膜的成相机理、提高薄膜的钉扎中心等问题对未来第二代高温超导带材的大规模应用具有重要意义。