制备软X光多层膜的转速控厚法

本文提出了一种新的监控软X光多层膜膜厚的方法——转速控厚法,利用这种方法镀制的设计周期厚度分别为8.4和10nm,周期数达50对和30对的W/C多层膜,经小角X光衍射测试,结果表明周期厚度随机误差在0.1nm左右。     

Green and high efficient synthesis of triaza‐benzo[b]fluoren‐6‐one derivatives in water under microwave irradiation

Triaza‐benzo[b]fluoren‐6‐one derivatives were synthesized via the three‐component reaction of aldehyde, cyclohexane‐1,3‐dione compound and 2‐aminobenzimidazole in water under microwave irradiation. The new protocol has the advantages of excellent yield, low cost, reduced environment impact, wide scope and convenient procedure.     

"Click" synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

By using "Click Chemistry", we achieved the facile synthesis of various affinity-based hydroxamate probes that enable generation of activity-based fingerprints of a variety of metalloproteases, including matrix metalloproteases (MMPs), in proteomics experiments.     

Improved blood compatibility of rapamycin-eluting stent by incorporating curcumin

This paper dealt with improving the blood compatibility of the rapamycin-eluting stent by incorporating curcumin. The rapamycin- and rapamycin/curcumin-loaded PLGA (poly(d,l-lactic acid-co-glycolic acid)) coatings were fabricated onto the surface of the stainless steel stents using an ultrasonic atomization spray method. The structure of the coating films was characterized by Fourier transform infrared spectroscopy (FTIR). The optical microscopy and scanning electron microscopy (SEM) images of the drug-eluting stents indicated that the surface of all drug-eluting stents was very smooth and uniform, and there were not webbings and "bridges" between struts. There were not any cracks and delaminations on stent surface after expanded by the angioplasty balloon. The in vitro platelet adhesion and activation were investigated by static platelet adhesion test and GMP140 (P-selection), respectively. The clotting time was examined by activated partially prothromplastin time (APTT) test. The fibrinogen adsorption on the drug-loaded PLGA films was evaluated by enzyme-linked immunosorbent assay (ELISA). All obtained data showed that incorporating curcumin in rapamycin-loaded PLGA coating can significantly decrease platelet adhesion and activation, prolong APTT clotting time as well as decrease the fibrinogen adsorption. All results indicated that incorporating curcumin in rapamycin-eluting coating obviously improve the blood compatibility of rapamycin-eluting stents. It was suggested that it may be possible to develop a drug-eluting stent which had the characteristics of not only good anti-proliferation but also improved anticoagulation.     

Copper‐Catalyzed Intermolecular Asymmetric Propargylic Dearomatization of Indoles

The first copper‐catalyzed intermolecular dearomatization of indoles by an asymmetric propargylic substitution reaction was developed. This method provides a highly efficient synthesis of versatile furoindoline and pyrroloindoline derivatives containing a quaternary carbon stereogenic center and a terminal alkyne moiety with up to 86 % yield and 98 % ee.     

An amperometric sensor for uric acid based on ordered mesoporous carbon-modified pyrolytic graphite electrode

A novel amperometric sensor for uric acid based on ordered mesoporous carbon modified pyrolytic graphite electrode was developed. Uric acid oxidation was easily catalyzed by this electrode in a phosphate buffer solution at pH 7.0, with an anodic potential decrease about 140 mV compared to bare pyrolytic graphite electrode. The uric acid level was determined by the amperometric method, at a constant potential of 0.31 mV, the catalytic current of uric acid vs. its concentration showed a good linearity in the range of 1.0 × 10⁻⁶−1.0 × 10⁻⁴ mol L⁻¹, with a correlation coefficient of 0.999. The detection limit was 4.0 × 10⁻⁷ mol L⁻¹. The proposed method could be effectively used for uric acid amperometric sensing in human urine.     

Catalytic asymmetric construction of spirocyclopentaneoxindoles by a combined Ru-catalyzed cross-metathesis/double Michael addition sequence

Biologically important and synthetically challenging spirocyclopentaneoxindoles with four contiguous stereocenters including one spiroquaternary stereocenter have been constructed in good yields (72-87%) with excellent diastereoselectivity (16:1→30:1 dr) and enantioselectivity (93→99% ee) by a combined Ru-catalyzed cross-metathesis/organocatalyzed asymmetric double-Michael addition sequence.     

One-pot microwave synthesis of water-dispersible, ultraphoto- and pH-stable, and highly fluorescent silicon quantum dots

Fluorescent silicon quantum dots (SiQDs) are facilely prepared via one-pot microwave-assisted synthesis. The as-prepared SiQDs feature excellent aqueous dispersibility, robust photo- and pH-stability, strong fluorescence, and favorable biocompatibility. Experiments show the SiQDs are superbly suitable for long-term immunofluorescent cellular imaging. Our results provide a new and invaluable methodology for large-scale synthesis of high-quality SiQDs, which are promising for various optoelectronic and biological applications.     

Ring-opening polymerisation of ɛ-caprolactone catalysed by Brønsted acids

Two new Brønsted acids [2,2′-ethylidene-bis (4,6-di-tert-butylphenol)] phosphoric acid (EDBPPOOH) and (3,3′,5,5′-tetra-tert-butylbiphenyl-2,2′-diol) phosphoric acid (TBPO-POOH) were synthesised and fully characterised by ¹H NMR and ¹³C NMR spectra and mass spectra. The ringopening polymerisation (ROP) of ?-caprolactone (?-CL) catalysed by the two Brønsted acids proceeded at 110°C without a solvent or at ambient temperature in toluene. Experimental results indicated that the two Brønsted acids were efficient catalysts for the ROP of ?-CL with moderate number-average molar mass (Mn) and narrow polydispersity indices (PDI). The catalytic activity of TBPO-POOH is higher than EDBP-POOH in the ROP of ?-CL. After benzyl alcohol was added, it was able to accelerate the polymerisation process. The polymerisation can also occur with the addition of water with a monomer/catalyst/initiator mole ratio of 100: 1: 1. The living polymerisation was ascertained by the linear relationships of the Mn vs. monomer conversion, then it was further confirmed by a second-feed experiment of a double monomer producing double Mn. A kinetic study of the relationships between monomer concentration and time revealed a first-order dependence on monomer concentration in the polymerisation. End-group analysis of ¹H NMR spectra and electrospray-ionisation mass spectra suggests that the two Brønsted acids are capable of catalysing and initiating the ROP of ?-CL.