Azadirachta indica leaves mediated green synthesized copper oxide nanoparticles induce apoptosis through activation of TNF-α and caspases signaling pathway against cancer cells

Green nanotechnology elucidates highly prioritized anticancer activity. We synthesized Copper oxide nanoparticles (CuONPs) using leaves of Azadirachta indica (A. indica) plants and studied the molecular mechanism of cancer cell apoptosis. After their synthesis, with the help of expository tools like Fourier transform infrared spectroscopy (FT-IR), Transmission electron microscopy (TEM), Dynamic light scattering (DLS) and surface zeta potential we confirmed the successful synthesis of CuONPs. Here, crystalline structure of green synthesized CuONPs of 36?±?8?nm size and spherical shape was able to kill MCF-7 and Hela cells, estimated by MTT assay. Successful internalization of Cu⁺² ions inside the cell was estimated by the atomic absorption study. Cellular uptake of Cu⁺² ions inflicted significant Reactive Oxygen Species (ROS) generation inside the cancer cells, thereby leading to DNA fragmentation as observed by DAPI staining. In in vivo model, CuONPs reduced the breast tumor volume in Balb/C mice and increased the mean survival time through the alteration of pro-inflammatory cytokines level. In case of both in vivo and in vitro models, CuONPs altered the pro-inflammatory cytokine level and pro-apoptotic protein expressions. In future, green synthesized CuONPs might be beneficial for its application as an anticancer drug in in vivo (mice model) and in vitro, though further study is needed on its toxicity.     

Versatility of 2,6-diacetylpyridine (dap) hydrazones in stabilizing uncommon coordination geometries of Mn(II): synthesis, spectroscopic, magnetic and structural characterization

Five seven- or eight-coordinate manganese complexes of hydrazone ligands have been prepared. Three seven-coordinate neutral Mn(II) complexes: [Mn(dapA2)]n (1), [Mn(dapB2)(H2O)2] (2), [Mn(dapS2)(H2O)2] (3) have been synthesized from the bis-Schiff bases of 2,6-diacetylpyridine: dap(AH)2, dap(BH)2 and dap(SH)2 (AH = anthraniloyl hydrazide, BH = benzoyl hydrazide, SH = salicyloyl hydrazide), respectively. Two eight-coordinate Mn(II) complexes: [Mn(dapS)2] (4) and [Mn(dapB)2].3H2O (5) have been synthesized from the mono-Schiff bases dapBH and dapSH, respectively. The complexes have been characterized by elemental analyses and by IR, UV-Vis., FAB mass, EI mass and EPR spectroscopy. The molecular structures of 1, 3.DMF and 4.DMF have been determined by single-crystal X-ray diffraction. The mono-Schiff bases are monoanionic and the bis-Schiff bases are dianionic. The octa-coordinated mono-Schiff base complex 4 adopts a dodecahedral geometry, while the hepta-coordinated bis-Schiff base complex 1 forms a one-dimensional linear polymeric chain. A weak antiferromagnetic exchange interaction (J=-0.15 cm(-1)) between the Mn(II) ions in is attributed to weak Mn...Mn interaction through the PhNH(2) moiety of the ligand, as indicated by extended-Hückel molecular orbital calculations. A good simulation of the EPR spectrum of a frozen solution (DMSO at 4 K) of compound 1 was obtained with g=2.0, D=0.1 cm(-1), E=0.01 cm(-1). The EPR spectrum of a powdered sample of compound 1 shows a large broadening of the signal, due in part, to the important zero-field splitting of the hepta-coordinated Mn(II) ion.     

Centrality dependence of high-p(T) hadron suppression in Au+Au collisions at sqrt[s(NN)]=130 GeV

Inclusive transverse momentum distributions of charged hadrons within 0.2相似文献   

The role of pinning and instability in a class of non-equilibrium growth models

We study the dynamics of a growing crystalline facet where the growth mechanism is controlled by the geometry of the local curvature. A continuum model, in (2+1) dimensions, is developed in analogy with the Kardar-Parisi-Zhang (KPZ) model is considered for the purpose. Following standard coarse graining procedures, it is shown that in the large time, long distance limit, the continuum model predicts a curvature independent KPZ phase, thereby suppressing all explicit effects of curvature and local pinning in the system, in the “perturbative” limit. A direct numerical integration of this growth equation, in 1+1 dimensions, supports this observation below a critical parametric range, above which generic instabilities, in the form of isolated pillared structures lead to deviations from standard scaling behaviour. Possibilities of controlling this instability by introducing statistically “irrelevant" (in the sense of renormalisation groups) higher ordered nonlinearities have also been discussed. Received 23 April 2002 / Received in final form 24 July 2002 Published online 31 October 2002 RID="a" ID="a"e-mail: akc@mpipks-dresden.mpg.de     

Nanotips: Growth,Model, and Applications

The tip morphology in the nanoscale is discussed as a member of the one-dimensional nanostructure family. Different growth techniques used for the synthesis of the nanotips have been outlined and compared against each other including, etching, pyrolysis, physical, and chemical vapour deposition. Growth models for hollow and solid nanotips are compared and discussed in detail with a thrust on the ‘cone-helix’ model for the hollow tips and the ‘platelet stacking’ model for the solid tips. Application of the nanotips in field emission, scanning probe microscopy, sensing, anti-reflection, and nanoindentation is discussed.     

Validity of an algebraic-variational approach to the theory of collective motion for an exactly soluble shell model with R(5) symmetry

An algebraic-variational approach to the theory of collective motion previously applied in variant forms to pairing and monopole interaction models is here developed for an exactly soluble shell model Hamiltonian with R(5) symmetry. The spectrum of this class of Hamiltonian operators has previously been shown to represent a two-dimensional vibrator-rotator. The approximation scheme developed yields almost exact results up to the two-phonon level in the spherical region and goes over smoothly into a theory of the lowest states of the ground state rotational band in the deformed regime.     

High spin isomer in151Sm

An investigation of the high spin isomer in¹⁵¹Sm was performed via the¹⁵⁰Nd(α, 3nγ) reaction at a projectile energy of 35 MeV. A newγ-transition, 693.6 keV was identified having an exponential delayed component. The transition feeds the 1912 keV state of the negative parity band built on theh _11/2 state. This transition was also observed in coincidence withγ-rays belonging to¹⁵¹Sm in theγ-γ coincidence experiment atE _α =37 MeV. A new isomeric state having energyE _x =2605.8 keV and half lifeT _1/2=23.1±3.5 ns is proposed.     

Symmetric lock-range multilevel quantized digital phase locked FMdemodulator

A dynamic modification algorithm of the conventional digital phase-locked loop (CDPLL) design parameters is proposed to get a modified DPLL (MDPLL) which has nearly symmetric two-sided acquisition range. With the help of extensive simulation results, it is established that in comparison to a CDPLL, the MDPLL has larger acquisition range and better FM demodulation capability. The performance degradation due to additive noise is more pronounced in the case of an MDPLL     

Rho0 production and possible modification in Au+Au and p+p collisions at square root [sNN] = 200 GeV

We report results on rho(770)(0)-->pi(+)pi(-) production at midrapidity in p+p and peripheral Au+Au collisions at sqrt[s(NN)]=200 GeV. This is the first direct measurement of rho(770)(0)-->pi(+)pi(-) in heavy-ion collisions. The measured rho(0) peak in the invariant mass distribution is shifted by approximately 40 MeV/c(2) in minimum bias p+p interactions and approximately 70 MeV/c(2) in peripheral Au+Au collisions. The rho(0) mass shift is dependent on transverse momentum and multiplicity. The modification of the rho(0) meson mass, width, and shape due to phase space and dynamical effects are discussed.     

Interferometry of direct photons in central 208Pb + 208Pb collisions at 158A GeV

Two-particle correlations of direct photons were measured in central 208Pb+208Pb collisions at 158A GeV. The invariant interferometric radii were extracted for 100相似文献