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61.
A regular perturbation analysis is presented for the following laminar natural convection flows of Newtonian fluids with temperature-dependent effective viscosity: a freely-rising plane plume, the flow above a horizontal line source on an adiabatic surface (a plane wall plume) and the flow adjacent to a vertical uniform flux surface for porous medium. The temperature-dependent effective viscosity introduces nonsimilarity into the governing equations. Numerical results are presented for the flow and heat transfer characteristics. 相似文献
62.
Abeer D. Algarni Ghada El Banby Sahar Ismail Walid El-Shafai Fathi E. Abd El-Samie Naglaa F. Soliman 《Entropy (Basel, Switzerland)》2020,22(12)
The security of information is necessary for the success of any system. So, there is a need to have a robust mechanism to ensure the verification of any person before allowing him to access the stored data. So, for purposes of increasing the security level and privacy of users against attacks, cancelable biometrics can be utilized. The principal objective of cancelable biometrics is to generate new distorted biometric templates to be stored in biometric databases instead of the original ones. This paper presents effective methods based on different discrete transforms, such as Discrete Fourier Transform (DFT), Fractional Fourier Transform (FrFT), Discrete Cosine Transform (DCT), and Discrete Wavelet Transform (DWT), in addition to matrix rotation to generate cancelable biometric templates, in order to meet revocability and prevent the restoration of the original templates from the generated cancelable ones. Rotated versions of the images are generated in either spatial or transform domains and added together to eliminate the ability to recover the original biometric templates. The cancelability performance is evaluated and tested through extensive simulation results for all proposed methods on a different face and fingerprint datasets. Low Equal Error Rate (EER) values with high AROC values reflect the efficiency of the proposed methods, especially those dependent on DCT and DFrFT. Moreover, a comparative study is performed to evaluate the proposed method with all transformations to select the best one from the security perspective. Furthermore, a comparative analysis is carried out to test the performance of the proposed schemes with the existing schemes. The obtained outcomes reveal the efficiency of the proposed cancelable biometric schemes by introducing an average AROC of 0.998, EER of 0.0023, FAR of 0.008, and FRR of 0.003. 相似文献
63.
Rasha Saad Suliman Sahar Saleh Alghamdi Rizwan Ali Ishrat Rahman Tariq Alqahtani Ibrahim K. Frah Dimah A. Aljatli Sarah Huwaizi Shatha Algheribe Zeyad Alehaideb Imadul Islam 《Molecules (Basel, Switzerland)》2022,27(8)
Electron-rich, nitrogenous heteroaromatic compounds interact more with biological/cellular components than their non-nitrogenous counterparts. The strong intermolecular interactions with proteins, enzymes, and receptors confer significant biological and therapeutic properties to the imidazole derivatives, giving rise to a well-known and extensively used range of therapeutic drugs used for infections, inflammation, and cancer, to name a few. The current study investigates the anti-cancer properties of fourteen previously synthesized nitrogenous heterocycles, derivatives of imidazole and oxazolone, on a panel of cancer cell lines and, in addition, predicts the molecular interactions, pharmacokinetic and safety profiles of these compounds. Method: The MTT and CellTiter-Glo® assays were used to screen the imidazole and oxazolone derivatives on six cancer cell lines: HL60, MDA-MB-321, KAIMRC1, KMIRC2, MCF-10A, and HCT8. Subsequently, in vitro tubulin staining and imaging were performed, and the level of apoptosis was measured using the Promega ApoTox-Glo® triplex assay. Furthermore, several computational tools were utilized to investigate the pharmacokinetics and safety profile, including PASS Online, SEA Search, the QikProp tool, SwissADME, ProTox-II, and an in silico molecular docking study on tubulin to identify the critical molecular interactions. Results: In vitro analysis identified compounds 8 and 9 to possess the most significant potent cytotoxic activity on the HL60 and MDA-MB-231 cell lines, supported by PASS Online anti-cancer predictions with pa scores of 0.413 and 0.434, respectively. In addition, compound 9 induced caspase 3/7 dependent-apoptosis and interfered with tubulin polymerization in the MDA-MB-231 cell line, consistent with in silico docking results, identifying binding similarity to the native ligand colchicine. All the derivatives, including compounds 8 and 9, had acceptable pharmacokinetics; however, the safety profile was suboptimal for all the tested derivates except compound 4. Conclusion: The imidazole derivative compound 9 is a promising anti-cancer agent that switches on caspase-dependent apoptotic cell death and modulates microtubule function. Therefore, it could be a lead compound for further drug optimization and development. 相似文献
64.
New complexes of 2-thione-4,6-diamino-5-hydroxypyrimidine (HTDAHP) with Fe(III), Ni(II), Ag(I) and Ru (II) are described.
IR, 1H-NMR and mass spectra, conductivity, magnetic and thermal measurements of the complexes are reported and their structures
discussed. HTDAHP behaves as a bidentate ligand, forming five membered hydroxyl-amino chelates or four-membered cyclic nitrogen-sulphur
chelates without any participation of the pendant amino or hydroxy groups in complexation. The biological activities of the
Ag(I) complexes against fungi (Aspergillus niger and Candida albicans) and bacteria (Staphylococcus aureus and Pseudomonas aeruginosa) have been investigated. 相似文献
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A straightforward method for the solid-phase synthesis of C-terminally modified polylysine dendrons has been developed by applying bisalkoxybenzaldehyde and trisalkoxybenzaldehyde linkers. The method has been used for the synthesis of polylysine dendrons with a variety of C-terminal ‘tail groups’ such as alkyl, propargyl, and dansyl to give dendrons in high crude purity. Furthermore, the method was successful for the synthesis of dendrons with multiple N-terminal pentapeptide groups together with C-terminal alkyl and propargyl tail groups. Finally, the method was shown to be well-suited for automated synthesis. 相似文献
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