Catalytic Atroposelective C7 Functionalisation of Indolines and Indoles

Axially chiral atropisomeric compounds are widely applied in asymmetric catalysis and medicinal chemistry. In particular, axially chiral indole- and indoline-based frameworks have been recognised as important heterobiaryl classes because they are the core units of bioactive natural alkaloids, chiral ligands and bioactive compounds. Among them, the synthesis of C7-substituted indole biaryls and the analogous indoline derivatives is particularly challenging, and methods for their efficient synthesis are in high demand. Transition-metal catalysis is considered one of the most efficient methods to construct atropisomers. Here, we report the enantioselective synthesis of C7-indolino- and C7-indolo biaryl atropisomers by means of C−H functionalisation catalysed by chiral RhJasCp complexes.     

An experimental investigation of pulsatile flow through a smooth constriction

Measurements of flow disturbances in the downstream region of modeled stenoses in a rigid tube, with upstream pulsatile flow are reported. Experiments were conducted over physiologically relevant mean Reynolds numbers of 600; based on the tube diameter and the time-averaged value of upstream centerline velocity. Contoured constrictions with 25%, 50% and 75% area reductions were investigated and velocity data were obtained from ensemble averaging techniques (phase-locked waveform). Experimental data over extensive spatial regions of poststenotic fields were taken, employing a two-component laser Doppler velocimeter LDV. Constant time sampling techniques for performing data or frequency analyses were used to avoid velocity bias and to study the evolution of poststenotic flow disturbances. It is found that different types of flow disturbances exist downstream of the constriction. Data analysis methods with the aid of flow visualization allow accurate classification of the disturbances which are sensitive indicators of mild to moderate constrictions. Although the present study was motivated by a biological situation, sufficient data were reported in detail that they may also be used by investigators working in computational fluid dynamics.     

Transmission behavior improvement of electro‐optic modulators for integrated photonic systems in the present communication technology

This paper has presented the transmission performance evaluation of different electro‐optic modulators (EOM) for ultra high switching speed operations and applications. As well as the optimization design parameters for different EOMs have been investigated, where the effective refractive index plays an essential role in the evaluation of the bandwidth structure. The effects of the operating parameters on the switching, modulating voltage, device performance index, and optical bandwidth are also investigated for different material‐based EOMs, where the transmission bit rate is evaluated by using non‐return‐to‐zero coding transmission technique. As well as lithium niobate, gallium arsenide, and poly methyl metha acrylate polymer EOMs have been developed for extensive use in high speed and high transmission performance optical fiber transmission systems. Copyright © 2013 John Wiley & Sons, Ltd.     

Acoustic technique to monitor the kinetics of porous development phenomena in viscoelastic media

In this paper, the potential of a low frequency acoustic technique for the study and characterisation of viscoelastic porous media is investigated. This work was based on the limits of ultrasonic applications in highly absorbent porous media. In this context, fermenting dough was used as a model propagation medium. This type of product has a very complex matrix in terms of texture, openings and moisture. The basic theory of sound in such matter is recalled, especially the effects of the scattering of sound energy in matrices like that of the product under investigation. Depending on the properties of the openings, acoustic velocity and intensity of sound were chosen to represent the state of evolution of the matter. A tap-test acoustic technique was employed and allowed a quality indicator to be obtained. The results of the validation step using various technological parameters indicate that a high degree of sensitivity can be reached with non-destructive acoustic techniques.     

PIN versus Avalanche photodiode gain optimization in zero cross correlation optical code division multiple access system

In this paper, we show details of zero cross correlation (ZCC) code development and investigate performance by measuring bit-error-rates compared to other optical code division multiple access (OCDMA) codes using Avalanche photodiode (APD) and PIN photodetector. We present a configuration to determine how optical OCDMA systems can be applied with PIN and APD photodetector. Analysis of Avalanche photodiode gain optimization is discussed in ZCC code system. We also present analytical and numerical theoretical results for data transmission of spectrally encoded incoherent OCDMA signal and how signal-noise is being affected by using these two photodetectors.     

Recovering boundary data: The Cauchy Stokes system

This paper is concerned with the severely ill-posed Cauchy–Stokes problem. We are interested in a data completion problem which is exploited to detect small leaks to control water loss Kim et al. (2008) [1]. This inverse problem is rephrased into an optimization one: An energy-like error functional is introduced. We prove that the optimality condition of the first order is equivalent to solving an interfacial equation which turns out to be a Cauchy-Steklov-Poincaré operator. Numerical trials highlight the efficiency of the method.     

Extrudate swell of linear and branched polyethylenes: ALE simulations and comparison with experiments

Extrudate swell is a common phenomenon observed in the polymer extrusion industry. Accurate prediction of the dimensions of an extrudate is important for appropriate design of dies for profile extrusion applications. Prediction of extrudate swell has been challenging due to (i) difficulties associated with accurate representation of the constitutive behavior of polymer melts, and (ii) difficulties associated with the simulation of free surfaces, which requires special techniques in the traditionally used Eulerian framework. In a previous work we had argued that an Arbitrary Lagrangian Eulerian (ALE) based finite element formulation may have advantages in simulating free surface deformations such as in extrudate swell. In the present work we reinforce this argument by comparing our ALE simulations with experimental data on the extrudate swell of commercial grades of linear polyethylene (LLDPE) and branched polyethylene (LDPE). Rheological behavior of the polymers was characterized in shear and uniaxial extensional deformations, and the data was modeled using either the Phan–Thien Tanner (PTT) model or the eXtended Pom–Pom (XPP) model. Additionally, flow birefringence and pressure drop measurements were done using a 10:1 contraction–expansion (CE) slit geometry in a MultiPass Rheometer. Simulated pressure drop and contours of the principal stress difference were compared with experimental data and were found to match well. This provided an independent test for the accuracy of the ALE code and the constitutive equations for simulating a processing-like flow. The polymers were extruded from long (L/D = 30) and short (L/D = 10) capillaries dies at 190 °C. ALE simulations were performed for the same extrusion conditions and the simulated extrudate swell showed good agreement with the experimental data.     

3D simulation of radionuclide transport in porous media

We present an efficient and easily implementable finite volume method simulating radionuclide transport through highly heterogeneous grounds in three space dimensions. The numerical concentration of the transported chemicals are proved to remain nonnegative and stable. Then, we run a realistic test case in which some radioactive iodine I¹²⁹ particles are released from a leak in an underground nuclear waste disposal site. The question of whether the radionuclide invades the underground and reach the ground surface is investigated. Because of the 3D nature of the problem, a particular emphasis is made on the control of CPU time. Copyright © 2009 John Wiley & Sons, Ltd.     

Chemoselective Bromination in a Two-Step Substitution Under the Influence of Tetrachlorosilane and N-Bromosuccinimide

The synthesis of gem dibromide carbonyl compounds via a cheep and readily available combined reagent from tetrachlorosilane and N-bromosuccinimide (TCS-NBS).