Implementation of a third-generation 1.1-GHz 64-bit microprocessor

This third-generation 1.1-GHz 64-bit UltraSPARC microprocessor provides 1-MB on-chip level-2 cache, 4-Gb/s off chip memory bandwidth, and a new 200 MHz JBus interface that supports one to four processors. The 87.5-million transistor chip is implemented in a seven-layer-metal copper 0.13-/spl mu/m CMOS process and dissipates 53 W at 1.3 V and 1.1 GHz.     

Investigation on time scales in a low Reynolds number jet flow using particle-tracking velocimetry

The near flow field of an axisymmetric water jet at Reynolds numbers between 2000 and 5000 is investigated using Particle-Tracking Velocimetry. Measurements are taken in the longitudinal section (along the mean flow) and in cross-sections (orthogonal to the mean flow). From the former, correlation coefficients of the two in-plane velocity components in a Lagrangian framework are obtained: thus Lagrangian integral scales can be computed. Those of the streamwise velocity (axial) component increase on moving away from the centreline, whereas the opposite happens for the vertical velocity (radial) component: integral time scales of the two components are almost equal at the interface between jet and ambient fluids. On the other hand, integral scales are almost constant or increase slightly with the axial direction. In cross-sections, fluid ejection and injection from the jet centreline are observed to be connected to counter-rotating vortices (mushroom): their number and size change with Reynolds number in agreement with results from other authors. The maximum ejection velocity (orthogonal to the mean jet flow), at 3 nozzle diameters downstream of the outlet, is found to be one half of the mean outlet velocity.     

A comparison between parallelization approaches in molecular dynamics simulations on GPUs

We test the relative performances of two different approaches to the computation of forces for molecular dynamics simulations on graphics processing units. A “vertex‐based” approach, where a computing thread is started per particle, is compared to an “edge‐based” approach, where a thread is started per each potentially non‐zero interaction. We find that the former is more efficient for systems with many simple interactions per particle while the latter is more efficient if the system has more complicated interactions or fewer of them. By comparing computation times on more and less recent graphics processing unit technology, we predict that, if the current trend of increasing the number of processing cores—as opposed to their computing power—remains, the “edge‐based” approach will gradually become the most efficient choice in an increasing number of cases. © 2014 Wiley Periodicals, Inc.     

The effect of boundary conditions by the side of the nozzle of a low Reynolds number jet

The near flow field of an axially symmetric water jet at Reynolds numbers from about 1,000 to 10,000 is investigated using laser-induced fluorescence (LIF), laser Doppler anemometry and particle tracking velocimetry. Spanwise and streamwise vortices are detected on the longitudinal plane and on cross-sections. Attention is focused onto the effects of rigid or free boundaries sideways to the nozzle outlet (no-slip or free-slip conditions), and particularly on the start up, growth and interaction of large vortical structures. On average, for the free-slip jet these structures develop more gradually and closer to the nozzle than for the no-slip jet; the local mixedness (derived from LIF measurements) is also higher for the free-slip case. Moreover, the measured velocity field decreases more slowly, with a longer potential core and a higher shear layer (momentum) thickness for the free-slip rather than for the no-slip conditions. The relation between spanwise and streamwise large-scale vortices is clarified by the observation that the ejection of fluid in cross-sections through streamwise vortices is coupled to the pairing of spanwise vortices on the longitudinal section.     

On Leon's criterion

Summary The theory of limit surfaces of resistance for isotropic materials in the space of the principal stress components is recalled. This resistance is viewed in terms of the phenomena of ductile or brittle failure that may arise in alternation for a given material, depending on the type of stress state. A transformation of coordinates is introduced that proves to be very useful for comparing the various limit conditions with that deriving from intrinsic curve theory. Reference is made to the criterion of Stassi, certainly the most reliable of the criteria that allow for dependence of the limit condition on the value of the principal intermediate stress. The theory of the intrinsic curve is generalised by means of Leon's modification, which interprets the phenomenon of tensile fracture. It is shown how Griffith's theory of brittle fracture leads to a limit condition that may be regarded as a special case of the one deriving from Leon's theory. Comparison with some experimental data shows that Leon's theory is well suitable for the study of brittle fracture. A generalisation that takes account of the influence of the principal intermediate stress and so permits good agreement with the experimental data in the field of ductile failure too, whilst conserving the characteristics of Leon's theory in brittle fracture, is proposed.

---

Sommario Si richiama la teoria delle superfici limiti di resistenza per materiali isotropi nello spazio delle componenti principali di tensione. Tale resistenza è intesa nei riguardi dei fenomeni di rottura duttile o fragile che possono intervenire in alternativa per uno stesso materiale in dipendenza dei diversi tipi di stato tensionale. Si introduce una trasformazione di coordinate che risulta particolarmente utile per il confronto delle varie condizioni limiti con quella derivante dalla teoria della curva intrinseca. In particolare si fa riferimento al criterio di Stassi, certo il più attendibile fra quelli che prendono in considerazione la dipendenza della condizione limite dal valore della tensione principale intermedia. La teoria della curva intrinseca viene generalizzata attraverso la modifica di Leon, che interpreta il fenomeno della crisi per distacco. Si mostra come la teoria di Griffith della rottura fragile conduca ad una condizione limite che si può considerare un caso particolare di quella derivante dalla teoria di Leon. Per confronto con alcuni dati sperimentali si verifica che questa ultima teoria bene si presta allo studio dei fenomeni di rottura fragile. Si propone una generalizzazione che, tenendo conto dell'influenza della tensione principale intermedia, consente di ottenere un buon accordo con l'esperienza anche nel campo di rottura duttile, pur conservando le caratteristiche della teoria di Leon in quello della rottura fragile.

     

Single cell 3-D platform to study ligand mobility in cell-cell contact

Lateral mobility and dimensionality have both been shown to influence cellular behavior, but have yet to be combined and applied in a single in vitro platform to address, e.g., cell adhesion in a setting mimicking the three-dimensional environment of neighboring cells in a reductionist way. To study the effect of the lateral mobility of cell adhesive ligands in three dimensions we present and characterize a platform, which enables patterning of single cells into microwells presenting a cell membrane mimetic interface pre-patterned to its walls. Soluble E-cadherin extracellular domains coupled through an optimized streptavidin-antibody linkage to lipids in a supported lipid bilayer (SPB) were presented on the microwell walls as either laterally mobile or immobile ligands. The fluidity was controlled through a small change in temperature by choosing phospholipids for the SPB with a lipid phase transition temperature around 30 °C. The platform thus enabled the investigation of cell adhesion to either laterally immobile or mobile E-cadherin ligands presented on the same cell membrane mimetic surface. Chinese hamster ovary (CHO) cells engineered to express E-cadherin that were cultured on the platform demonstrated that enhanced cadherin lateral mobility significantly decreased the formation of actin bundles and resulted in more diffuse actin organization, while constraining the cell shape to that of the microwell. This example highlights the potential to use in vitro cell culture platforms to mimic direct cell-cell interaction in a controlled environment that nevertheless captures the dynamic nature of the native cell environment.     

Monte Carlo and event-driven dynamics of Brownian particles with orientational degrees of freedom

Recently, a simple scaling argument was introduced that allows us to map, with some precautions, Brownian and Monte Carlo dynamics for spherical particles. Here, we extend the scaling to study systems that have orientational degrees of freedom and carefully asses its validity over a wide region of temperature and density. Our work allows us to devise a Brownian Monte Carlo algorithm that produces, to a good approximation, physically meaningful trajectories with a minimum programming effort, although at the expense of some sampling efficiency.     

Simultaneous size and velocity measurements of cavitating microbubbles using interferometric laser imaging

In this paper, interferometric laser imaging droplet sizing—ILIDS—is applied to incipient cavitation in the wake of a marine propeller model with the aim to evaluate simultaneously bubbles velocity and diameter. Until now, the feasibility of this technique has been demonstrated especially in sprays of water droplets in air where an optimal light scattering is obtained thanks to the spherical shape and to the given relative refractive index. In the present setup, to allow simultaneous size–velocity measurements, a single camera is used and the object distance over lens diameter ratio is kept as small as possible, thus increasing the size measurement resolution. These details, together with the algorithms used for image analysis at each single frame and in two consecutive frames, allow deriving cavitation bubble size and velocity distributions in the propeller wake.     

Resolution of (R,S)-flurbiprofen catalysed by dry mycelia in organic solvent

Mycelia of Aspergillus oryzae display high enantioselectivity towards (R)-flurbiprofen and can be efficiently used in pure organic solvent for the resolution of (R,S)-flurbiprofen through esterification. The use of the lyophilized mycelia facilitates the separation process so that in one step the two enantiomers of flurbiprofen, which are both valuable for pharmaceutical applications, can be easily separated. The biotransformation can be carried out in different apolar solvents using different primary alcohols as nucleophiles under very mild conditions.     

Solution of large dense complex matrix equations using a fastFourier transform (FFT)-based wavelet-like methodology

Wavelet-like transformations have been used in the past to compress dense large matrices into a sparse system. However, they generally are implemented through a finite impulse response filter realized through the formulation of Daubechies (1992). A method is proposed to use a very high order filter (namely an ideal one) and use the computationally efficient fast Fourier transform (FFT) to carry out the multiresolution analysis. The goal here is to reduce the redundancy in the system and also guarantee that the wavelet coefficients drop off much faster. Hence, the efficiency of the new procedure becomes clear for very high order filters. The advantage of the FFT-based procedure utilizing ideal filters is that it can be computationally efficient and for very large matrices may yield a sparse matrix. However, this is achieved, as well known in the literature, at the expense of robustness, which may lead to a larger reconstruction error due to the presence of the Gibb's phenomenon. Numerical examples are presented to illustrate the efficiency of this procedure as conjectured in the literature