Cancer Cell Membrane‐Coated Nanoparticles for Personalized Therapy in Patient‐Derived Xenograft Models

Cell membrane coating nanotechnology, which endows nanoparticles with unique properties, displays excellent translational potential in cancer diagnosis and therapy. However, the preparation and evaluation of these cell membrane‐coated nanoparticles are based on cell lines and cell‐line‐based xenograft mouse models. The feasibility of cell membrane‐camouflaged nanomaterials is tested in a preclinical setting. Head and neck squamous cell carcinoma (HNSCC) patient‐derived tumor cell (PDTC) membranes are coated onto gelatin nanoparticles (GNPs) and the resulting PDTC@GNPs show efficient targeting to homotypic tumor cells and tissues in patient‐derived xenograft (PDX) models. When the donor‐derived cell membrane of PDTC@GNPs matched those of the host cells, significant targeting capability is observed. In contrast, mismatch between the donor and host results in weak targeting. Furthermore, it is demonstrated that autologous separation and administration of cellular membranes and anticancer cisplatin (Pt)‐loaded PDTC@GNPs, respectively, lead to almost complete tumor ablation in a subcutaneous model and effectively inhibit tumor recurrence in a postsurgery model. The work presented here reinforces the translation of these biomimetic nanoparticles for clinical applications and offers a simple, safe, and effective strategy for personalized cancer treatment.     

锗(Ⅳ)─氨基酸息夫碱配合物的合成与表征

以水杨醛和ａ－氨基酸综合而成的息夫碱作为配体，与四氯化锗作生成型的佤合物，并通过元素分析，摩尔电导，红外光谱，核磁共振、紫外－可见光谱、热分析等手段研究了配合物的组成和性质。     

沿海港口表层沉积物中三丁基锡化合物的顶空固相微萃取气相色谱测定

利用顶空固相微萃取与气相色谱火焰光度检测法测定广东汕头港表层沉积物中的三丁基锡化合物(TBT) ,探索了样品的最佳超声处理时间、缓冲溶液 pH值及萃取时间 ,该法可方便、灵敏地测定沉积物中的三丁基锡 ,检出限达到0.28×10 -9(w)。     

THE CRYSTAL STRUCTURE OF RARE EARTH COMPLEX WITH AMINO ACIDS Ⅱ The Crystal Structure of Gtutamate Comptex of Erbium Perchtorate

The crystat structure of {[Er_2(L—Glu)_2(H_2O)_6](ClO_4)_2·3H_2O)_2 has been studied by X-ray diffraction. The crystal is monoctinic with space group P2_1 and cell parameters a=19.987(3) , b=16.505(3) , c=11.040(2) , β=104.69(1)~o, V=3538(1) , Z=2, Dc=2.29 g. cm~(-3), μ=53.2 cm~(-1), F(000)=2384. The asymmetric unit contains two complex motecules and four centre ions. Each erbium (Ⅲ) is coordinated by five oxygen donors from four different glutamates and four oxygen donors from the aqua ligand to form a nine coordination potyhedron. The mean distances of Er—0 (carboxylate) and Er—Ow are 2.439 and 2.41 respectivety. The finat R and Rw are 0.043 and 0. 058, respectivety.     

交变磁场传感器法拉第屏蔽的研究

为了更有效的接收所需信号,我们除了进一步提高传感器本身的性能外,还要消除一些不必要的干扰.在检测低频交变磁场而且磁场信号极其微弱时,首先要选用高性能的交变磁场传感器将交变磁场信号转换为电信号,然后采用一系列的选频放大等电子技术,这样在两者之间就会产生不必要的电场耦合,影响对有用信号的准确测量,为了阻断该电场耦合,对交变磁场传感器采用法拉第屏蔽是不可或缺的重要环节.     

铜钼叠层基板的热学特性仿真研究

采用有限元方法,仿真研究了不同层数和材料厚度比的铜钼叠层基板对芯片散热特性的影响。结果表明,2层和3层的铜钼叠层材料均可以有效综合Cu高热导率和Mo低膨胀系数的优点。在相同铜钼总厚度比的情况下,相比于2层材料,3层材料可以实现更好的散热特性。对于1 mm的基板厚度,铜钼铜厚度比为0.2∶0.6∶0.2时可以同时实现较低的温度和热应力。通过调整基板结构参数,可以显著改变芯片的最高温度和最大热应力,满足不同封装领域的需求。     

光阱刚度与实验条件的依赖关系

对微小力的测量是光镊系统的重要功能。主要研究了进行微小力测量时所需的重要参数——光阱刚度与实验条件的依赖关系。在以He-Ne激光器为光源的光镊系统中，得到了光阱刚度随着阱位距离样品池底面高度的提升而减小，随着被捕获小球直径的增加而减小，以及光阱刚度与激光功率具有线性的依赖关系等经验规律，并作了定性的讨论。最后给出了该系统所能达到的测力精度和测力范围。     

ESR of Gamma Irradiated C2H204.2H2O Single Crystal

The gamma-irradiated samples of vacuumed powder and single crystal of C₂H₂O₄.2H₂O have been investigated by ESR method. the spectra of these single crystal and unvacuumed powder are attributed to R C HOH radical, but the peaks belonging to this radical in the gamma irradiated powder sample are not observed in the spectrum after having been vacuumed. After a and g tensor values of this radical have been calculated, it was observed to be anisotropic. At low temperature, a considerable change in the spectrum has not been observed.     

Monte-Carlo simulation of optical trap stiffness measurement

The high precision calibration of optical trap stiffness is the foundation of the weak force measurement in an optical tweezers system. And the accuracy of the trap stiffness measurement is limited by the bandwidth of the acquisition system. In this article, such an influence is analyzed and discussed. The stiffness measuring process using an acquisition system with a finite acquisition time is numerically simulated by using Monte-Carlo method. Then the simulated results are analyzed by thermal motion analysis method to deduce the trap stiffness for different trapping system and for measuring systems with different acquisition time. As a comparison the power spectrum analysis method is used to study the thermal motion of the bead and to compute the trap stiffness for the same acquisition system, from which it is concluded that the bandwidth of the acquisition system is determined by its acquisition time, not the sampling frequency. The influence of the finite acquisition time or the limited bandwidth on the trap stiffness measurement is discussed. The numerical simulation shows that the measured position, which is here the average position within the acquisition time, shifts to the trap center due to the trapping force, which gives an alternative interpretation for the deviation of the measured stiffness from the true trap stiffness.     

Effects of novel hybrid nanofluid (TiO2–Cu/EG) and geometrical parameters of triangular rib mounted in a duct on heat transfer and flow characteristics

Journal of Thermal Analysis and Calorimetry - Heat transfer and flow characteristics have been numerically analyzed by using four different fluids [pure ethylene glycol (EG), TiO2/EG and Cu/EG...