Periodic motions of spinning rigid spacecraft under influence of gravitational and magnetic fields

The motion of a magnetized axisymmetric spacecraft about its center of mass in a circular orbit is considered, taking the gravitational and magnetic effects of the central body into account. Equations of motion of the reduced system are transformed to equations of plane motion of a charged particle under the action of electric and magnetic fields. Stationary motions of the system are determined and periodic motions near to them are constructed using the Lyapounoff theorem of the holomorphic integral.     

MOS Realization of the Conjectured Simplest Chaotic Equation

This paper presents a general block diagram of a third-order linear differential equation using current mode techniques. The realization of the conjectured simplest chaotic equation of Elwakil and Kennedy based on G_m – C technology is given. The metal oxide semiconductor circuit is composed of 20 transistors and three grounded capacitors, can operate from a supply voltage as low as ±1.5 V, and covers a very wide range of frequencies. PSpice simulation results using 0.5 µm Mietec technology are given. A numerical solution is also included to verify the circuit operation.     

Electrogravitational instability of cylindrical interface acted upon by a varying electric field

The electrodynamic instability of a self-gravitating dielectric fluid penetrated by a uniform axial electric field surrounded by a self-gravitating vacuum pervaded by a varying electric field is investigated. A general eigenvalue relation valid to all possible (symmetric and asymmetric) modes of perturbation for all (short and long) wavelengths is derived and discussed in detail. The model is gravitationally stable to the pure asymmetric disturbances modes while to symmetric modes it is as if the longitudinal wavenumber normalized with respect to the jet radius is equal to or greater than 1.0668 and vice versa. The axial electric fields pervaded interior and exterior to the cylinder are stabilizing for all disturbances modes according to some restrictions. The transverse varying electric field is purely stabilizing in the symmetric disturbance for all wavelengths, while it is stabilizing in the asymmetric disturbance under some restrictions. The electrodynamic force has a strong stabilizing influence in the symmetric mode and can suppress the gravitational instability above a certain value of the basic electric field.     

The Recognition of and Reactions to Nucleic Acid Nanoparticles by Human Immune Cells

The relatively straightforward methods of designing and assembling various functional nucleic acids into nanoparticles offer advantages for applications in diverse diagnostic and therapeutic approaches. However, due to the novelty of this approach, nucleic acid nanoparticles (NANPs) are not yet used in the clinic. The immune recognition of NANPs is among the areas of preclinical investigation aimed at enabling the translation of these novel materials into clinical settings. NANPs’ interactions with the complement system, coagulation systems, and immune cells are essential components of their preclinical safety portfolio. It has been established that NANPs’ physicochemical properties—composition, shape, and size—determine their interactions with immune cells (primarily blood plasmacytoid dendritic cells and monocytes), enable recognition by pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs), and mediate the subsequent cytokine response. However, unlike traditional therapeutic nucleic acids (e.g., CpG oligonucleotides), NANPs do not trigger a cytokine response unless they are delivered into the cells using a carrier. Recently, it was discovered that the type of carrier provides an additional tool for regulating both the spectrum and the magnitude of the cytokine response to NANPs. Herein, we review the current knowledge of NANPs’ interactions with various components of the immune system to emphasize the unique properties of these nanomaterials and highlight opportunities for their use in vaccines and immunotherapy.     

1-Aryl-3-(1<Emphasis Type="Italic">H</Emphasis>-imidazol-1-yl)propan-1-ol esters: synthesis,anti-<Emphasis Type="Italic">Candida</Emphasis>potential and molecular modeling studies

Background

An increased incidence of fungal infections, both invasive and superficial, has been witnessed over the last two decades. Candida species seem to be the main etiology of nosocomial fungal infections worldwide with Candida albicans, which is commensal in healthy individuals, accounting for the majority of invasive Candida infections with about 30-40% of mortality.

Results

New aromatic and heterocyclic esters 5a-k of 1-aryl-3-(1H-imidazol-1-yl)propan-1-ols 4a-d were successfully synthesized and evaluated for their anti-Candida potential. Compound 5a emerged as the most active congener among the newly synthesized compounds 5a-k with MIC value of 0.0833 μmol/mL as compared with fluconazole (MIC value >1.6325 μmol/mL). Additionally, molecular modeling studies were conducted on a set of anti-Candida albicans compounds.

Conclusion

The newly synthesized esters 5a-k showed more potent anti-Candida activities than fluconazole. Compounds 7 and 8 revealed significant anti-Candida albicans activity and were able to effectively satisfy the proposed pharmacophore geometry, using the energy accessible conformers (E_conf?<?20 kcal/mol).

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One-step multiple component isolation from the oil of Crinitaria tatarica (Less.) Sojak by preparative capillary gas chromatography with characterization by spectroscopic and spectrometric techniques and evaluation of biological activity

Gas chromatographic analysis revealed that the oil of Crinitaria tatarica was rich in sabinene (32.1%), β-pinene (8.8%), and two unknown (M+200) compounds (I) and (II) (21.4% and 3.4%). One-step multiple fractionation of the oil and separation of two unknown constituents were performed using preparative capillary gas chromatography connected to preparative fraction collector system. This combination allowed separation and recover of sufficient quantities of two unknown compounds with high purity from complex oil matrix. Separation conditions (column temperature, cooling temperature, flow rate, injection volume, cut time) were optimized to achieve the best isolation and successful collection. The target compounds were separated from the oil using a HP Innowax (Walt & Jennings Scientific, Wilmington, DE, USA) preparative capillary column in rapid one-step manner with 95.0% purity. Trapping of the isolated compounds in collector system was facilitated by cooling with liquid nitrogen. Structure determination was accomplished by spectral analysis including ultraviolet, nuclear magnetic rezonance, and high-resolution electrospray ionization mass spectrometry. Z- (I) and E-artemidin (II) were isolated for the first time from this species. Crinitaria tatarica oil and Z- (I) and E-artemidin (II) were evaluated for biological activity.     

A validated chiral HPLC method for the determination of mebeverine HCl enantiomers in pharmaceutical dosage forms and spiked rat plasma

A new, precise, simple and accurate HPLC method was developed for the first time to separate and determine mebeverine enantiomers. Enantiomeric resolution was achieved on a cellulose Tris (3,5-dimethylphenyl carbamate) column known as Chiralcel OD, with UV detection at 263 nm. The mobile phase consisted of n-hexane, isopropyl alcohol and triethylamine (90:9.9:0.1 v/v/v). Sample run time was 18 min. On using the chromatographic conditions described, mebeverine enantiomers were well resolved with mean retention times of about 11 and 14 min. A linear response (r>0.999) was observed over the concentration range 0.5-20 microg/mL racemic mebeverine. Precision, accuracy and stability were studied according to ICH guidelines. The limit of detection was found to be 0.05 microg/mL for each enantiomer of mebeverine. The proposed method was applied for analysis of mebeverine in commercially available tablets dosage formulations. Examples of application to biological samples are also given. Reanalysis of samples several weeks after the initial analysis showed no degradation of mebeverine.     

The influence of the d-core states on the calculation of the crystal structure of Zn with the optimized model potential

Shaw model potential has been used to calculate the structural energies of Zn using different model potential parameters. The effects of changing the model potentials, of using energy-wavenumber characteristics calculated with intervals of q/2k_F = 0.05 and 0.025, and of using different interpolation methods on the structural energies are investigated.