A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells

We describe a novel strategy to increase the selective toxicity of genotoxic compounds. The strategy involves the synthesis of bifunctional molecules capable of forming DNA adducts that have high affinity for specific proteins in target cells. It is proposed that the association of such proteins with damaged sites in DNA can compromise protein function and/or DNA repair resulting in increased toxicity. We describe the synthesis of a bifunctional compound consisting of an aniline mustard linked to the 7alpha position of estradiol. This novel compound can form covalent DNA adducts that have high affinity for the estrogen receptor. Breast cancer cells that express high levels of the estrogen receptor showed increased sensitivity to the cytotoxic effects of the new compound.     

Experimentelle Untersuchung des Wärmeüberganges durch freie Konvektion an waagerechten Rippenrohren in einem zylindrischen Behälter

Experimental measurements of heat transfer by free convection in a cylindrical waterfilled enclosure from a horizontal finned tube of small fin height is reported. The measured heat transfers are presented in form of correlation equationsNu=f(Ra). The Rayleigh numbers have been alternatively defined with the annulus height, core diameter and an equivalent diameter defined for the finned tube. The correlation equations have been formulated for heat transfer (i) in an infinite medium and (ii) in an annulus. Results show that for the experimental annulus gap/enclosure diameter ratio of 24.66 and 40.74, the heat transfer analysis based on infinite medium assumption shows a somewhat better correlation although the influence of the enclosure cannot be completely neglected. Defining the Rayleigh number with an equivalent diameter makes it possible to compare the experimental measurements with those from a smooth tube.     

Kinetics of oxidative coupling of phenols: Oxidation of naphthols by alkaline hexacyanoferrate (III)

The oxidation of naphthols by alkaline hexacyanoferrate(III), at constant ionic strength, gave coupled products. The rate of the reaction was dependent on the first powers of the concentrations of substrate, oxidant, and alkali. The activation energies were 31.8 and 34.5 kJ/mol for α naphthol and β naphthol, respectively. The reaction pathway was via the formation of a radical intermediate, which was detected by electron spin resonance spectroscopy.     

Investigation of some branch and bound strategies for the solution of mixed integer linear programs

The branch and bound method of solving the mixed integer linear programming problem is summarized. The flexibility of this technique is examined through experiments with different branching and subproblem selection strategies, and the efficacy of these various heuristics is assessed.     

Efficient proton-templated synthesis of 18- to 38-membered tetraimino(amino)diphenol macrocyclic ligands: structural features and spectroscopic properties

A whole range of Robson-type tetraiminodiphenol macrocyclic ligands have been prepared as their perchlorate salts [H4L](ClO4)2 in high yield (ca. 90%) by a single-step [2 + 2] condensation reaction between 4-methyl(or tert-butyl)-2,6-diformyl(or diacyl)phenols and alpha,omega-diaminoalkanes (C2-C12) in the presence of acetic acid and NaClO4. The reduction of these 18- to 38-membered macrocyclic salts with NaBH4 have afforded corresponding tetraaminodiphenol macrocycles H2L'. The X-ray crystal structures of two of the tetraiminodiphenol macrocycles with the C2 and C4 lateral chains have been determined, and the optimized configurations for all of the macrocycles have been obtained by molecular mechanics calculations. The macrocycles have been characterized by elemental analysis and by IR, absorption, emission, and NMR spectroscopic study. The protonated tetraiminodiphenol macrocycles exhibit strong fluoroscence in methanol, acetonitrile, and nitromethane and undergo quenching when treated with triethylamine. The neutral macrocycles H2L, isolated by treating [H4L](ClO4)2 with excess of triethylamine, lack luminescence, as do the reduced tetraaminodiphenol macrocycles H2L'. The hydrolytic cleavage of [H4L](ClO4)2 has been studied.     

Estimation of Sea Level Muon Energy Spectrum at High Latitude from the Latest Primary Nucleon Spectra Near the Top of the Atmosphere

The vertical muon energy spectra at sea level have been estimated from directly measured primary cosmic-ray nucleon spectrum. The hadronic energy moments have been calculated from the CERN LEBC EHS data on the Lorentz invariant cross-section results on pp ^±X and pp K^±X inclusive reactions and are duly corrected for A–A collisions. Finally, the sea level muon energy spectra have been calculated from the decay of conventional mesons, using standard formulation. The estimated muon spectra are found to be in good agreement with the directly measured muon spectra obtained from the different experiments.     

Models of Network Access Using Feedback Fluid Queues

At the access to networks, in contrast to the core, distances and feedback delays, as well as link capacities are small, which has network engineering implications that are investigated in this paper. We consider a single point in the access network which multiplexes several bursty users. The users adapt their sending rates based on feedback from the access multiplexer. Important parameters are the user's peak transmission rate p, which is the access line speed, the user's guaranteed minimum rate r, and the bound on the fraction of lost data. Two feedback schemes are proposed. In both schemes the users are allowed to send at rate p if the system is relatively lightly loaded, at rate r during periods of congestion, and at a rate between r and p, in an intermediate region. For both feedback schemes we present an exact analysis, under the assumption that the users' file sizes and think times have exponential distributions. We use our techniques to design the schemes jointly with admission control, i.e., the selection of the number of admissible users, to maximize throughput for given p, r and . Next we consider the case in which the number of users is large. Under a specific scaling, we derive explicit large deviations asymptotics for both models. We discuss the extension to general distributions of user data and think times.