Self-Mineralizing Dnazyme Hydrogel as a Multifaceted Bone Microenvironment Amendment for Promoting Osteogenesis in Osteoporosis

The accumulation of reactive oxygen species (ROS) and minimal osteogenic raw material in the osteoporotic bone microenvironment greatly inhibits the activity of osteoblasts. Herein, it is originally proposed to construct a biomatrix multifaceted bone microenvironment amendment -Mineralized zippered G4-Hemin DNAzyme hydrogel (MDH)-to improve osteoporotic osteogenic capacity and promote high-quality bone defect repair. The programmed design of the rolling circle amplified DNA hydrogel synthesis system allows the introduction of massive amounts of zippered G4-Hemin DNAzyme in MDH. The zippered G4-Hemin DNAzyme highly mimics the tight catalytic configuration of horseradish peroxidase and exerts excellent enzyme-like activity with considerable ROS molecule scavenging ability. In addition, the DNA amplification by-product pyrophosphate is ingeniously employed as a sufficient phosphorus source, thus constituting an autonomous mineralization system for waste reuse through the introduction of pyrophosphate hydrolase and calcium ions, which deposits in MDH as an osteogenic raw material and addresses the challenge of DNA hydrogel bio-application stability. The remarkable in vitro and in vivo outcomes demonstrate that MDH can effectively improve the oxidative stress status of osteoblasts, restore the balance of mitochondrial membrane potential, and reduce apoptosis, ultimately demonstrating superior osteogenic capacity.     

On a class of least-element complementarity problems

The present paper studies the linear complementarity problem of finding vectorsx andy inR ₊ ⁿ such thatc + Dx + y 0,b – x 0 andx ^T (c + Dx + y) = y ^T (b – x) = 0 whereD is aZ-matrix andb > 0. Complementarity problems of this nature arise, for example, from the minimization of certain quadratic functions subject to upper and lower bounds on the variables. Two least-element characterizations of solutions to the above linear complementarity problem are established first. Next, a new and direct method to solve this class of problems, which depends on the idea of least-element solution is presented. Finally, applications and computational experience with its implementation are discussed.Research partially supported by the National Science Foundation Grant MCS 71-03341 A04 and the Air Force Office of Scientific Research Contract F 44620 14 C 0079.     

Modeling and simulation for a drop-impact analysis of multi-layered printed circuit boards

Multi-layered printed circuit boards (PCBs) contain a multi-layered structure that is suitable for high-speed and high-frequency applications. Hence, they are used extensively in electronic packaging assemblies for high-density applications. However, numerous composite parts and complex material properties of multi-layer PCBs complicate the reliability simulation of PCB model. This paper deals with a finite element analysis intended to describe numerically the behavior of multi-layered multi-materials PCB model (combination of metallic and composite plies) in the drop-impact performance. Through the comparison of physical drop test results, the fully multi-layered model illustrates higher accuracy if compared with that of the traditional simplified isotropic model and orthotropic model. The effects of material properties for the multi-layer PCB under drop-impact shock have also been investigated.     

Voice over wireless local area network

This paper introduces the special issue on voice over wireless local area networks (VoWLAN), which aim to foster interaction among researchers from both academia and industry in networking, wireless communications, and mobile computing. The special issue includes an article investigating the issue of determining an appropriate pricing strategy for VoWLAN provisioning. Also featured are two articles on polling as a solution for supporting real-time traffic over WLANs and another on media optimization network architecture (MONA).     

Construction of Binary Quantum Error-Correcting Codes from Orthogonal Array

By using difference schemes, orthogonal partitions and a replacement method, some new methods to construct pure quantum error-correcting codes are provided from orthogonal arrays. As an application of these methods, we construct several infinite series of quantum error-correcting codes including some optimal ones. Compared with the existing binary quantum codes, more new codes can be constructed, which have a lower number of terms (i.e., the number of computational basis states) for each of their basis states.     

飞秒激光制备的全单模光纤法布里-珀罗干涉高温传感器

提出了一种全单模光纤的本征型法布里-珀罗干涉(IFPI)高温传感器。光纤IFPI传感器由飞秒激光在标准单模光纤上刻写的一对内部反射镜和腔内光纤构成,其反射光谱的干涉条纹对比度达到10dB,而插入损耗仅为0.1dB。实验结果表明,该传感器的测量温度可达1000℃,温度灵敏度为14.9pm/℃。而且在重复测量中,反射光谱具有良好的一致性,可以准确地实现高温传感。飞秒激光制备的光纤IFPI高温传感器完全由标准单模光纤构成,结构简单、成本低廉,易于连接现有的光纤器件构成光纤传感网络,在实际工程中有较大的应用价值。