TrocCl Mediated Efficient Synthesis of Nitriles from Primary Amides

In order to establish a rapid conversion method of primary amides to nitriles, various types of carboxamides were treated with 2,2,2-trichloroethyl chloroformate and Et₃N, as a dehydrating agent to obtain the desired nitriles in 82–95% yields.     

Magnesium Methoxide-Assisted Synthesis of 2,4,6-Triaryl Pyridines

A new three-component reaction of chalcones, ketones, and ammonia assisted by magnesium methoxide is described. The corresponding 2,4,6-triaryl pyridines (Kröhnke pyridines) are formed in fair to good yields (34–76%) within 3 h. The method also provides a facile way to synthesize 2(6)-difluoromethyl pyridines via an interesting mechanism.     

Micron Particles of AlN/Al: Efficient,Novel, and Reusable Heterogeneous Catalyst for the Synthesis of Bis(indolyl)methanes

The present work introduces for the first time the catalytic utility of micron particulate aluminium nitride (AlN/Al) as a novel and reusable heterogeneous catalyst for the synthesis of bis(indolyl)methanes involving the electrophilic substitution of indoles on aldehydes. The catalyst is recyclable and works without any significant change in its catalytic activity.     

Preferential Reactivity of Pyridylmagnesiumchloride with N,N-Dialkyl Arylamides over Carbonitriles: Synthesis of 2-(Aroyl) Pyridines

Reaction of 2-pyridylmagnesium chlorides with N,N-dialkyl arylamides afford exclusively 2-(aroyl) pyridines in high yields and purity without the formation of any tertiary alcohol. This method employs easily available raw materials and avoids the use of hazardous lithium reagents and cryogenic conditions. Further, preferential reactivity of this Grignard reagent with N,N-dialkyl arylamides over its carbonitrile counterparts offers a variety of 2-(aroyl) pyridines including the ones containing carbonitrile groups on the aryl ring.     

Bromamine-B/PdCl2 is an Efficient System for the Synthesis of Anthranilic Acids from Indoles and Indigos

A convenient method has been developed for the conversion of indoles and indigos into anthranilic acids in good to excellent yields using a bromamine-B/PdCl₂ system. The general process utilizes our efficient method for the oxidation of indoles and indigos in alkaline (pH 12) acetonitrile/water (1:1) at 60 °C.     

Oxone as a Mild,Inexpensive, and Environmentally Benign Oxidant for the α-Thiocyanation of Ketones

An efficient and direct approach for the α-thiocyanation of ketones with α-hydrogens has been developed using ammonium thiocyanate as a thiocyanating agent and oxone as an oxidant in methanol.     

Synthesis and Antimicrobial Activity of 1‐[(Substituted Carbamoyl)Amino]‐1H,3H‐1λ5‐[1,3,2]oxazaphospholo[3,4‐a]benzimidazol‐1‐ones

1‐[(Substituted carbamoyl)amino]‐1H,3H‐1λ⁵‐[1,3,2]oxazaphospholo[3,4‐a]benzimidazol‐1‐ones were synthesized by reacting benzimidazole 2‐methanol (4) with different chlorides of carbamidophosphoric acids (3) in the presence of triethylamine at 40–45°C. Their ¹H, ¹³C, and ³¹P NMR spectral data were discussed. The title compounds were tested for their activity against the fungi Aspergillus niger and Fusarium solani and bacteria Staphylococcus aureus and Escherichia coli. These compounds showed moderate antibacterial activity when compared with antifungal activity.     

NaOH/Et3N-Promoted Stereoselective One-Pot Synthesis of α-Diazo Oxime Ethers via Diazo Transfer Reaction

For the first time, we have observed a combined effect of two bases NaOH/Et₃N to promote the diazo transfer reaction of β-oximino esters. This unusual synergistic effect has been employed to obtain α-diazo oxime ethers directly from β-keto esters by one-pot process. This method is simple and cost-effective and the reagents are readily available.     

Choline Chloride/Urea Ionic Liquid Catalyzed a Convenient One-Pot Synthesis of Indole-3-propanamide Derivatives

A sequential three-component reaction of aromatic aldehydes with Meldrum's acid and N-methyl indole in the presence of choline chloride/urea ionic liquid as green catalyst has been described. In this one-pot multicomponent reaction, a series of indole-3-propanamide derivatives were synthesized with good to excellent yields. This methodology shows several advantages including fast reaction, easy isolation, operational simplicity that make it a useful and attractive option for the library generation of indole-3-propanamides (5a–l) for drug discovery.

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