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71.
A Ghavami B D Johnston M T Jensen B Svensson B M Pinto 《Journal of the American Chemical Society》2001,123(26):6268-6271
The syntheses of two nitrogen analogues (11 and 12) of the naturally occurring sulfonium ion, salacinol (7) are described. The latter compound is one of the active principles in the aqueous extracts of Salacia reticulata that are traditionally used in Sri Lanka and India for the treatment of diabetes. The synthetic strategy relies on the nucleophilic attack of a 1,4-dideoxy-1,4-imino-D- or L-arabinitol at the least hindered carbon of 2,4-O-benzylidene D- or L-erythritol-1,3-cyclic sulfate. The nitrogen analogues bear a permanent positive charge and serve as mimics of the sulfonium ion. We reasoned that these ammonium derivatives should function in a manner similar to that of known glycosidase inhibitors of the alkaloid class such as castanospermine (4) and deoxynojirimycin (5). Enzyme inhibition assays indicate that salacinol (7) is a weak (K(i) = 1.7 mM) inhibitor of glucoamylase, whereas compounds 11 and 12 inhibit glucoamylase with K(i) values in the range approximately 10-fold higher. The nitrogen analogues 11 and 12 showed no significant inhibitory effect of either barley alpha-amylase (AMY1) or porcine pancreatic alpha-amylase (PPA) at concentrations of 5 mM. In contrast, salacinol (7) inhibited AMY1 and PPA in the micromolar range, with K(i) values of 15 +/- 1 and 10 +/- 2 microM, respectively. 相似文献
72.
Haruki Nishimura Mamiko Inamori Yukitoshi Sanada Mohammad Ghavami 《Wireless Personal Communications》2013,68(3):711-725
In impulse-radio or DS/SS UWB communications, a prerake scheme has been proposed to achieve path diversity while reducing computational complexity in a mobile terminal. On the other hand, in an OFDM system, fractional sampling (FS) has been proposed to achieve path diversity with a single antenna. However, in the FS-OFDM system, it is necessary to oversample a received signal that leads to larger power consumption in the terminal side. In this paper, a precoded transmit path diversity scheme in an OFDM system has been proposed. The proposed scheme can achieve path diversity without oversampling the received signal. 相似文献
73.
Ali Khalafi‐Nezhad Mohammad Navid Soltani Rad A. A. Moosavi‐Movahedi M. Kosari 《Helvetica chimica acta》2007,90(4):730-737
The syntheses of the novel acyclic nucleosides 5a – 5m , carrying different N‐[(benzyloxy)(aryl)methyl] substituents, are described (Scheme). These compounds could be prepared in medium‐to‐good yields by either direct or silyl‐assisted coupling of the electrophiles 6 with either purine or pyrimidine nucleobases, or with different imidazole derivatives. The reactivity of the positively charged electrophilic intermediates derived from 6 upon Cl? abstraction was rationalized by ab initio HF/6‐311G quantum‐mechanic calculations. The positive charge was found to be dispersed differently, depending on the electronic properties of the aryl substituents. 相似文献
74.
Natalija van Well Sitaram Ramakrishnan Ketty Beauvois Navid Qureshi Eric Ressouche Markos Skoulatos Robert Georgii Oksana Zaharko Sander van Smaalen 《Annalen der Physik》2020,532(7):2000147
The triangular antiferromagnetic Cs2CuCl4-xBrx mixed system is studied by neutron single-crystal diffraction in magnetic field. It shows a rich magnetic phase diagram consisting of four regimes depending on the Br concentration and is characterized by different exchange coupling mechanisms. For the investigated compositions from regime I (0 < x ≤ 1.5), a critical magnetic field Bc is found for a Br concentration x = 0.8 at Bc = 8.10(1) T and for x = 1.1 at Bc = 7.73(1) T and from regime IV (3.2 < x < 4) for x = 3.3 at Bc = 0.99(3) T. For magnetic fields larger than the respective Bc, magnetic superlattice reflections of these compounds are not found. The incommensurate magnetic wave vector q = (0, 0.470, 0) appears below the ordering temperature TN = 0.51(1) K for Cs2CuCl3.2Br0.8, and q = (0, 0.418, 0) below TN = 1.00(6) K for Cs2CuCl0.3Br3.7. Neutron diffraction experiments at around 60 mK for x = 3.7 in a magnetic field show the critical magnetic field at Bc = 7.94(16) T and the formation of the second magnetic phase at around 8.5 T depending on the temperature. Inelastic neutron scattering experiments for the compound from regime III (2 < x ≤ 3.2) with x = 2.2 show dynamical correlations at a temperature around 50 mK giving evidence for a spin liquid phase. 相似文献
75.
Leung C Lu Z Esfandiari N Casper RF Sun Y 《IEEE transactions on bio-medical engineering》2011,58(4):935-942
Sperm immobilization is a requisite step in intracytoplasmic sperm injection (ICSI). Conventionally, sperm immobilization is performed manually, which entails long training hours and stringent skills. Manual sperm immobilization also has the limitation of low success rates and poor reproducibility due to human fatigue and skill variations across operators. This paper presents a system for fully automated sperm immobilization to eliminate limitations in manual operation. Integrating computer vision and motion control algorithms, the automated system is able to visually track a sperm and control a micropipette to immobilize the sperm. A robust sperm tail tracking algorithm is developed to locate the optimal position on the sperm tail for sperm immobilization. The system demonstrates: 1) an average sperm tail tracking error of 0.95 μm; 2) a sperm tail visual tracking success rate of 96%; 3) a sperm immobilization success rate of 88.2% (based on 1000 trials); and 4) a speed of 6-7 s per successful immobilization. 相似文献
76.
Hamidreza Ali-Asgari Dehaghi Saeedeh Mazinani Davood Zaarei Mohammadreza Kalaee Hamed Jabari Navid Sedaghat 《Journal of Thermal Analysis and Calorimetry》2013,114(1):185-194
Systematic study about the effect of acrylonitrile–butadiene rubber (NBR) concentration on the fracture toughness and thermal behavior of epoxy resin is conducted in this study. NBR is solved in an aromatic hydrocarbon solvent and is added to epoxy resin. We used diethylene-teriamin as the curing agent for epoxy resin. Tensile test results, performed followed by molding procedure, show that the toughness is improved owing to the increase of rubber content. Scanning electron microscopy (SEM) and atomic force microscopy besides thermogravimetric analysis (TG) are used to investigate the epoxy/rubber interface and chemical decomposition of the resultant mixture. The thermal behavior of cured epoxy resin was analyzed via TG instrument at different heating rates. Thermogravimetry curves showed that the thermal decomposition of epoxy system was occurred in only one stage regardless of the rubber content. The apparent activation energies of the rubber/epoxy systems containing 0, 5, and 10 phr of rubber were determined by Flynn–Wall–Ozawa, Kissinger–Akahira–Sunose, and Friedman methods. The results prove that the thermal stability of epoxy resin was decreased with enhancing the rubber content. However, the trend of changing activation energy versus conversions is totally different followed by adding the elastomer to the system compared to neat epoxy resin. Moreover, the results obtained via our proposed facile solution blending method are compared to those of resins modified with nano-powdered elastomer. 相似文献
77.
Hamid R. Zare Zahra Ghanbari Navid Nasirizadeh Ali Benvidi 《Comptes Rendus Chimie》2013,16(3):287-295
In this study, ruthenium oxide nanoparticles were electrochemically deposited on the surface of a glassy carbon electrode (RuON-GCE). Electrochemical studies indicate that a modified electrode (RuON-GCE) plays the role of an excellent bifunctional electrocatalyst for the oxidation of adrenaline (AD) and uric acid (UA) in two different potentials. The charge transfer coefficient (α) and the heterogeneous charge transfer rate constant (k′) between the analytes and the electrodeposited nanoparticles were determined using cyclic voltammetry experiments. Through a different pulse voltammetric (DPV) method, the plot of the electrocatalytic current versus AD and UA concentrations emerged to be constituted of two linear segments with different sensitivities. Furthermore, the detection limits of AD and UA were estimated. In DPV, RuON-GCE could separate the oxidation peak potentials of AD, UA, and cysteine (Cys) present in the same solution though, at the bare GCE, the peak potentials were indistinguishable. Finally, the modified electrode activity was studied for the electrocatalytic determination of AD in an injection solution and UA in a human urine sample. The results were found satisfactory. 相似文献
78.
79.
Mohammad Navid Soltani Rad Ali Khalafi-Nezhad Mohammad Ali Faghihi Abolfath Parhami 《Tetrahedron》2008,64(8):1778-1785
A convenient and efficient one-pot N-alkylation of nucleobases from alcohols using N-(p-toluenesulfonyl)imidazole (TsIm) is described. In this method, treatment of alcohols with a mixture of purine or pyrimidine nucleobase, TsIm, K2CO3, and triethylamine in refluxing DMF regioselectively furnishes the corresponding N-alkyl nucleobases in good yields. This methodology is highly efficient for various structurally diverse primary alcohols. 相似文献
80.
Bakhtyar Sepehri Zeinabe Hassanzadeh Raouf Ghavami 《Journal of the Iranian Chemical Society》2016,13(8):1525-1537
In the present study, we mainly focused on new synthesized 1,7-diazacarbazole derivatives (44 active molecules) as Chk1 inhibitors to build 3D-QSAR model. Comparative molecular field analysis (CoMFA) model with three principal components was developed. The relative contributions in building of CoMFA model were 64.41 % for steric field and 35.59 % for electrostatic field. R 2 values for training and test sets of CoMFA model were 0.8724 and 0.7818, respectively, and squared correlation coefficient for leave-one-out cross-validation test (q 2) was 0.6753. To improve the predictive power, a new 3D-QSAR model was developed by using radial basis function network (RBFN) and score of CoMFA interactions energy values as input variables. Scores 1, 2 and 3 were used as input variables, and a RBFN model with seven centers and spread value equal to 95 was developed to create a nonlinear 3D-QSAR model. R 2 values for training and test sets were 0.9613 and 0.8564, and q 2 for leave-one-out cross-validation test was 0.9258. Docking of all molecules to 3DX ligand binding site of Chk1 receptor indicated six interactions as pharmacological interactions between compounds and binding site of receptors. These pharmacological interactions were hydrogen bonding with LEU-15 and GLU-85 in main chain and four van der Waals interactions with LEU-15, VAL-23, TYR-86 and LEU-137 in side chain. CoMFA contour plots were used to design new inhibitors, and inhibitory activity of each compound was predicted by using CoMFA and RBFN models. 相似文献