Catalysis by Amberlite IR-120 resin: a rapid and green method for the synthesis of phenols from arylboronic acids under metal, ligand, and base-free conditions

A clean process has been developed for the ipso-hydroxylation of aryl and heteroaryl boronic acids to the corresponding phenols using commercially available and recyclable Amberlite IR-120 resin and aqueous hydrogen peroxide as an oxidizing agent. The ion-exchange sulfonic acid resin catalyst could be readily recycled by filtration and directly reused at least four times without any significant loss of activity.     

Enhancement of Anti-Tumoral Properties of Paclitaxel Nano-Crystals by Conjugation of Folic Acid to Pluronic F127: Formulation Optimization,In Vitro and In Vivo Study

A brand-new nano-crystal (NC) version of the hydrophobic drug Paclitaxel (PT) were formulated for cancer treatment. A stable NC formulation for the administration of PT was created using the triblock co-polymer Pluronic F127. To achieve maximum entrapment effectiveness and minimal particle size, the formulation was improved using the central composite design by considering agitation speed and vacuum pressure at five levels (coded as +1.414, +1, 0, −1, and −1.414). According to the Design Expert software’s predictions, 13 runs were created and evaluated for the chosen responses. The formulation prepared with an agitation speed of 1260 RPM and a vacuum pressure of 77.53 mbar can meet the requirements of the ideal formulation in order to achieve 142.56 nm of PS and 75.18% EE, according to the level of desirability (D = 0.959). Folic acid was conjugated to Pluronic F127 to create folate receptor-targeted NC. The drug release profile of the nano-crystals in vitro demonstrated sustained release over an extended period. Folate receptor (FR)-targeted NC (O-PT-NC-Folate) has also been prepared by conjugating folic acid to Pluronic F127. MTT test is used to validate the targeting efficacy on the FR-positive human oral cancer cell line (KB). At pharmacologically relevant concentrations, the PT nano-crystal formulation did not cause hemolysis. Compared to non-targeted NC of PT, the O-PT-NC-Folate showed a comparable but more sustained anti-cancer effect, according to an in vivo anti-tumor investigation in NCI/ADR-RES cell lines. The remarkable anti-tumor effectiveness, minimal toxicity, and simplicity of scale-up manufacturing of the NC formulations indicate their potential for clinical development. Other hydrophobic medications that are formulated into nano-systems for improved therapy may benefit from the formulation approach.     

Constrained melting of graphene-based phase change nanocomposites inside a sphere

Journal of Thermal Analysis and Calorimetry - In the present work, the melting behavior of a fatty acid-based phase change material (PCM) with the addition of functionalized graphene nanoplatelets...     

A filter based bit allocation scheme for subband compression ofHDTV

The authors compare the subband compression capabilities of eight filter sets (consisting of linear-phase quadrature mirror filters (QMFs), perfect reconstruction filters, and nonlinear phase wavelets) at different bit rates, using-a filter-based bit allocation procedure. Using DPCM and PCM in HDTV subband coding, it is found that QMFs have an edge over the rest.     

Design of band-notched antenna with DG-CEBG

Ultra-wideband (UWB) disc monopole antenna with crescent shaped slot for double band-notched features is presented. Planned antenna discards worldwide interoperability for microwave access (WiMAX) band (3.3–3.6 GHz) and wireless local area network (WLAN) band (5–6 GHz). Defected ground compact electromagnetic band gap (DG-CEBG) designs are used to accomplish band notches in WiMAX and WLAN bands. Defected ground planes are utilised to achieve compactness in electromagnetic band gap (EBG) structures. The proposed WiMAX and WLAN DG-CEBG designs show a compactness of around 46% and 50%, respectively, over mushroom EBG structures. Parametric analyses of DG-CEBG design factors are carried out to control the notched frequencies. Stepwise notch transition from upper to lower frequencies is presented with incremental inductance augmentation. The proposed antenna is made-up on low-cost FR-4 substrate of complete extents as (42 × 50 × 1.6) mm³.Fabricated sample antenna shows excellent consistency in simulated and measured outcomes.     

An efficient synthesis and structural aspects of hexakis(arylseleno)benzenes and hexakis(arylselenomethyl)benzenes

An efficient synthesis and structural aspects of a novel class of selenium bearing hexa-hosts by the reaction of hexafluorobenzene or hexakis(bromomethyl) benzene with RSe⁻ ions is demonstrated. However, under identical reaction conditions, our attempts to prepare tellurium analogues by the reaction of RTe⁻ (R = Ph or p-CH₃C₆H₄-) with hexafluorobenzene or hexakis(bromomethyl)benzene to obtain (RTe)₆C₆ and (RTeCH₂)₆C₆ proved to be difficult.     

Synthesis and antimicrobial activity of 6,6′‐arylidene‐bis‐[5‐hydroxy‐9‐methyl‐2,3‐diaryl thieno[3,2‐g‐]thiocoumarins]

A variety of novel 6,6′‐arylidene‐bis‐[5‐hydroxy‐9‐methyl‐2,3‐diaryl‐thieno[3,2‐g]thiocoumarins] 3a‐d , 4a‐d , 5a‐d , and 6a‐d were obtained by a reaction between 5‐hydroxy‐9‐methyl‐2,3‐diarylthieno[3,2‐g]thiocoumarins 1a‐d with aromatic aldehydes 2a‐d in isopropyl alcohol. The synthesized compounds were tested for their antimicrobial activity.     

A photocatalytic comparison study between tin complex and carboxylic acid derivatives of porphyrin/TiO2 composites

Research on Chemical Intermediates - We synthesized a novel dihydroxotin(IV) porphyrin complex with full structural confirmation. The tin complex further converted to TiO2 composite...     

Design and optimization analysis of dual material gate on DG-IMOS

An impact ionization MOSFET (IMOS) is evolved for overcoming the constraint of less than 60 mV/decade sub-threshold slope (SS) of conventional MOSFET at room temperature.In this work,first,the device performance of the p-type double gate impact ionization MOSFET (DG-IMOS) is optimized by adjusting the device design parameters.The adjusted parameters are ratio of gate and intrinsic length,gate dielectric thickness and gate work function.Secondly,the DMG (dual material gate) DG-IMOS is proposed and investigated.This DMG DG-IMOS is further optimized to obtain the best possible performance parameters.Simulation results reveal that DMG DG-IMOS when compared to DG-IMOS,shows better ION,ION/IOFF ratio,and RF parameters.Results show that by properly tuning the lengths of two materials at a ratio of 1.5 in DMG DG-IMOS,optimized performance is achieved including ION/IoFF ratio of 2.87 × 109 A/μm with ION as 11.87 × 10-4 A/μm and transconductance of 1.06 × 10-3 S/μm.It is analyzed that length of drain side material should be greater than the length of source side material to attain the higher transconductance in DMG DG-IMOS.     

Radical scavenging activity of decalpoline,a novel compound characterized from <Emphasis Type="Italic">Decalepis hamiltonii</Emphasis>

The ethanol extract of Decalepis hamiltonii roots was subjected to antioxidant activity-guided fractionation by repeated silica gel column chromatography to get a pure antioxidant compound which was subjected to extensive analysis by UV, IR, LC-MS, and 2D HMQC NMR. The spectral data of the isolated compound was analyzed, and its structure was elucidated as decalpoline, a novel antioxidant compound not reported so far. Decalpoline exhibited multiple antioxidant properties like DPPH scavenging activity, superoxide radical scavenging activity, lipid peroxidation inhibitory activity, metal chelating and total reducing activity.