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Design and synthesis of novel series of 1,3,4-oxadiazoles containing FQs derivatives and screened their antibacterial, antimycobacterial properties. The synthesized compounds were characterized by different spectral techniques like IR, 1H NMR, 13C NMR, mass and elemental analysis. The results of the antimicrobial activity and compounds 6d, 6b, 6e, 6f and 6a demonstrated potent antibacterial activities with zone of inhibition of 42, 36, 37, 34 and 30 mm against S. aureus, E. faecalis, S. pneumoniae, E. coli and K. pneumoniae, respectively. 1,3,4-Oxadiazole derivatives 6a, 6b, 6 g were showed excellent antimycobacterial activity against M. smegmatis H37Rv with MICs 22.35, 16.20, 20.28 µg/mL, respectively. FQs 6d and 6b exhibited highest hydrogen bonding interactions with Asp83 (3.11 A?), Ser80 (2.15 A?) Asp27 (σ-σ), Arg87 (Π-Π), Arg87 (Π-Π), Ser80 (σ-σ), Ala84 (σ-σ) and binding energies ΔG?=????6.41, ??6.97 kcal/mol with active site of topoisomerase-IV from S. pneumoniae [4KPE]. We performed a computational investigation of compounds 6a–j for their absorption, distribution, metabolism and excretion (ADME) properties by using the Molinspiration, Molsoft toolkits. The ligands 6f, 6d and 6b reveal the highest pharmacokinetic properties and possess maximum drug-likeness model score 1.59, 1.46 and 1.23, respectively.
Graphic abstractIn Wireless Sensor Network, sensed data reflects two types of correlations of physical attributes: spatial and temporal. In this paper, a scheme named, Adaptive Prediction Strategy with ClusTering (APSCT) is proposed. In APSCT, a data-driven clustering and grey prediction model is used to exploit both the correlations. APSCT minimizes the transmission of messages in the network. However, the use of prediction includes additional computation overhead. There is a trade-off between prediction accuracy and energy consumption in computation and communication in wireless networks. This paper also gives an approach to calculate the upper and lower bound of the prediction interval which is used to evaluate different confidence levels and provides an energy-efficient sensor environment. Simulation is carried out on real-world data collected by Intel Berkeley Lab and results are compared with existing approaches.
相似文献This paper illustrates the performance of bit error rate based selection combining (BER-SC) protocol for adaptive cooperative cognitive radios. In the proposed framework, the unlicensed (i.e. secondary) system utilizes an adaptive mode of transmission to help the licensed (i.e. primary) system to achieve the desired quality of service in exchange for opportunistic spectrum access. The total transmission is divided in two phases. In Phase I, the primary transmitter (PT) broadcasts the data to the primary receiver (PR), which is overheard by the secondary transmitter (ST) and secondary receiver (SR). In Phase II, ST decodes the primary data and linearly combines its own data with the primary data. Using M-QAM the combined data is adaptively modulated, where M = 4, 16 or 64 depending on the received channel feedback, and relayed to PR and SR. At PR, BER-SC is employed to retrieve the primary data, and at SR interference cancellation is used to retrieve the secondary data. The analytical expressions are derived for the BER and the outage probability. The obtained results demonstrate the higher performance gains for both primary and secondary system by using adaptive mode of transmission at ST and BER-SC at PR.
相似文献The latest developments in mobile computing technology have increased the computing capabilities of smart mobile devices (SMDs). However, SMDs are still constrained by low bandwidth, processing potential, storage capacity, and battery lifetime. To overcome these problems, the rich resources and powerful computational cloud is tapped for enabling intensive applications on SMDs. In Mobile Cloud Computing (MCC), application processing services of computational clouds are leveraged for alleviating resource limitations in SMDs. The particular deficiency of distributed architecture and runtime partitioning of the elastic mobile application are the challenging aspects of current offloading models. To address these issues of traditional models for computational offloading in MCC, this paper proposes a novel distributed and elastic applications processing (DEAP) model for intensive applications in MCC. We present an analytical model to evaluate the proposed DEAP model, and test a prototype application in the real MCC environment to demonstrate the usefulness of DEAP model. Computational offloading using the DEAP model minimizes resources utilization on SMD in the distributed processing of intensive mobile applications. Evaluation indicates a reduction of 74.6% in the overhead of runtime application partitioning and a 66.6% reduction in the CPU utilization for the execution of the application on SMD.
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