Towards Ensuring Reliability of Vehicular Ad Hoc Networks Using a Relay Selection Techniques and D2D Communications in 5G Networks

Wireless Personal Communications - Benefiting from unlimited power supply, vehicular ad hoc networks (VANETs), in a 5G platform, can deal superiorly with the challenges of providing high...     

Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs

Poorly soluble drugs constitute more than 60% of currently marketed pharmaceuticals with over two-thirds of promising new chemical entities failing to enter a clinical setting due to solubility issues. Although oral formulations have made some impact, alternative enhancement strategies for administration of such molecules are actively sought. Over the last decade, innovation on a global scale has enabled the expansion of the frontiers of microarray patches (MAPs) further than ever before. Initially designed to load low doses of hydrophilic and potent therapeutic agents, MAPs are now becoming a viable strategy for the immediate and long-acting delivery of poorly soluble drugs through the skin. This together with the advantages of transdermal administration over the oral and parenteral routes, make of MAPs an appealing platform for the development of products with increased patient compliance. Undoubtedly, MAPs will soon become a readily available therapeutic alternative, and experts from academia, industry and regulatory bodies are working together aiming to facilitate the progression of MAPs toward safe and effective clinical use. This review aims to highlight the ability of MAPs to deliver poorly soluble actives, discuss the mechanisms behind in-skin drug absorption, and evaluate the future direction of the field.     

A Spiral Tribometer for Dynamic Friction Measurements

Basically there exists a significant interest in dynamic friction models [1]. These dynamic models describe μ as a time dependent process parameter. The indentification of the belonging parameters needs a special kind of measurements. This is due to the fact that the measurements with the classical pin on disk arrangement give stationary values of μ only, the measurements of dynamic properties are even infeasible. A new advanced tribometer has been developed. This tribometer allows measurements of complex unsteady friction processes. The experimental characteristics and the realization of this novel tribometer are presented by concrete measurements. (© 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Trace determination of EDTA from water samples using dispersive liquid–liquid microextraction coupled with HPLC-DAD

Dispersive liquid–liquid microextraction (DLLME) in conjunction with high-performance liquid chromatography-diode array detection (HPLC-DAD) has been applied to the extraction and determination of EDTA in sediments and water samples. The effect of extraction, nature and volume of disperser solvent, pH value of sample solution, extraction time and extraction temperature were investigated. Under the optimal conditions the analytical range of EDTA was from 3.0 to 50.0 μg L^?1 with a correlation coefficient of 0.9982 and a detection limit of 1.7 μg L^?1. The relative standard deviation (RSD) was less than 5.4% (n?=?5), and the recovery values were in the range of 89–95%. The simplicity, high enrichment, high recovery and good repeatability are the main advantages of the method presented. The DLLME-HPLC-DAD method was successfully applied to the analysis of EDTA in aqueous samples.     

Solubility of H2S in ionic liquids [hmim][PF6], [hmim][BF4], and [hmim][Tf2N]

The solubility of hydrogen sulphide in three ionic liquids, viz. 1-hexyl-3-methylilmidazolium hexafluorophosphate ([hmim][PF₆]), 1-hexyl-3-methylimidazolium tetrafluoroborate ([hmim][BF₄]), and 1-hexyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([hmim][Tf₂N]), at temperatures ranging from 303.15 K to 343.15 K and pressures up to 1.1 MPa were determined. The solubility values were correlated using the Krichevsky–Kasarnovsky equation and Henry’s constants were obtained at different temperatures. Partial molar thermodynamic functions of solvation such as standard Gibbs free energy, enthalpy, and entropy were calculated from the solubility results. Comparison of the values obtained show that the solubility of H₂S in these three ionic liquids was in the sequence: [hmim][BF₄] > [hmim][PF₆] ≈ [hmim][Tf₂N].     

A Simple and Efficient Procedure for Synthesis of Optically Active 1,2,4‐Triazolo‐[3,4‐b]‐1,3,4‐Thiadiazole Derivatives Containing l‐Amino Acid Moieties

Some new and optically active 1,2,4‐triazolo thiadiazoles bearing N‐phthaloyl‐l ‐amino acids were synthesized by reaction of 4‐amino‐5‐(3‐ or 4‐)pyridyl‐3‐mercapto‐(4H)‐1,2,4‐triazoles with N‐phthaloyl‐l ‐amino acids in the presence of phosphorus oxychloride. All the newly synthesized compounds were confirmed by IR, ¹H NMR, ¹³C NMR and elemental analysis.     

A chaotic secure communication scheme using fractional chaotic systems based on an extended fractional Kalman filter

In recent years chaotic secure communication and chaos synchronization have received ever increasing attention. In this paper, for the first time, a fractional chaotic communication method using an extended fractional Kalman filter is presented. The chaotic synchronization is implemented by the EFKF design in the presence of channel additive noise and processing noise. Encoding chaotic communication achieves a satisfactory, typical secure communication scheme. In the proposed system, security is enhanced based on spreading the signal in frequency and encrypting it in time domain. In this paper, the main advantages of using fractional order systems, increasing nonlinearity and spreading the power spectrum are highlighted. To illustrate the effectiveness of the proposed scheme, a numerical example based on the fractional Lorenz dynamical system is presented and the results are compared to the integer Lorenz system.     

Hydrothermally grown nano-manganese oxide on clinoptilolite for low-temperature propane-selective catalytic reduction of NO<Subscript>x</Subscript>

A novel nano-size Mn_xO_y/clinoptilolite catalyst of high activity for propane-SCR reaction of NO_x at low temperatures has been synthesized by a hydrothermal method in a temperature range of 80–180 °C. The optimum synthesis temperature resulting in maximum NO_x conversion was 150 °C. An optimum manganese oxide loading of 0.2 wt.% results in the best catalytic behavior (71% NO_x conversion). All catalysts exhibited an optimal propane-SCR reaction temperature of 200 °C. The optimum catalyst produces no detectable CO (GHSV 27,000 h) at 200 °C. Manganese in the optimum catalyst exists as Mn²⁺ (37.8%), Mn³⁺ (14.2%), and Mn⁴⁺ (48%).

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Graphical abstract Flake-like manganese oxide nanostructures (indicated by an arrow in the TEM picture) next to the clinoptilolite zeolite sheet-like crystals result in a promising low-temperature propane-selective catalytic reduction of NO_x.

     

A 5th-order ΣΔ modulator with combination of op-Amp and CBSC circuit for ADSL applications

In this letter, a 5th-Order single-loop low distortion Sigma–Delta Modulator (SDM) is implemented with the combination of the comparator-based switched-capacitor (CBSC)-based and op-amp-based techniques for asymmetric digital subscriber line (ADSL) applications. This structure, which uses integrator (CBSC-based) and IIR filter (op-amp-based) concurrently, has relatively fewer feed-forward paths and modulator coefficients for sensitivity reduction to mismatch. To lower the power consumption of the modulator, the integrators are implemented with CBSC, the IIR filter block is implemented by single OTA, and a passive adder is used to realize the adder at the input of the 5-bit quantizer. The design purpose is minimizing the power consumption while the dynamic performance maintains high. As shown in the simulation result, for a 2-MHz signal bandwidth, the modulator achieves a dynamic range (DR) of 86.5 dB and a peak signal-to-noise and distortion ratio (SNDR) of 85 dB with an oversampling ratio of 8. In addition it consumes 18.75 mW from a 1.8-V power supply at 32 MS/s, which obtains a figure of merit of 1.6e−3.     

Preparation of new supramolecular liquid-crystalline polyesters containing 3-chloro-4-(alkoxy)benzoic acids

Supramolecular liquid-crystalline polyester complexes based on intermolecular hydrogen bonds between the carboxylic group and the pyridyl moieties was prepared by using non-liquid-crystalline H-donors, [3-chloro-4-(butyloxy)benzoic acid (2a), 3-chloro-4-(octyloxy)benzoic acid (2b), 3-chloro-4-(dodecyloxy)benzoic acid (2c) and 3-chloro-4-(tetradecyloxy)benzoic acid (2d)] and H-acceptor-polyester containing pyridyl units. Intermolecular hydrogen bond formation was confirmed by Fourier transform infrared spectroscopy. The liquid-crystalline behavior of the complex formed was established by differential scanning calorimetry (DSC) and polarizing optical microscopy (POM). The polyester complexes containing 2c and 2d donor components exhibit liquid crystalline mesophase and behave as side-chain liquid-crystalline polymers. Compared with unsubstituted parent acid, the presence of chloro group as a lateral substituent has a little negative effect on the induction of liquid crystallinity on the polyester complexes systems. The results show that the more stability of the obtained H-bonded complexes in comparison with analogues without 3-Cl substituents is due to the increased acidity of benzoic acid moiety.