The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd‐catalyzed cross‐couplings to be run using ≤1000 ppm of this pre‐catalyst. Applications to Suzuki–Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures. Comparisons with existing state‐of‐the‐art ligands and catalysts are discussed herein. 相似文献
On the basis of the far higher solubility of oxygen gas inside the hydrocarbon core of nanomicelles, metal and peroxide free aerobic oxidation of aryl alkynes to β‐ketosulfones has been achieved in water at room temperature. Many examples are offered that illustrate broad functional group tolerance. The overall process is environmentally friendly, documented by the associated low E Factors. 相似文献
Several new amyloid-β (Aβ) aggregation inhibitors were synthesized according to our theory that a hydrophilic moiety could be attached to the Aβ-recognition unit for the purpose of preventing amyloid plaque formation. A distyrylbenzene-derivative, DSB(EEX)(3), which consider the Aβ recognition unit (DSB, 1,4-distyrylbenzene) and expected to bind to amyloid fibrils (β-sheet structure), was combined with the hydrophilic aggregation disrupting element (EEX) (E, Glu; X, 2-(2-(2-aminoethoxy)ethoxy)acetic acid). This DSB(EEX)(3) compound, compared to several others synthesized similarly, was found to be the most active for reducing Aβ toxicity toward IMR-32 human neuroblastoma cells. Moreover, its inhibition of Aβ-aggregation or fibril formation was directly confirmed by transmission electron microscopy and atomic force microscopy. These results suggest that the Aβ aggregation inhibitor DSB(EEX)(3) disrupts clumps of Aβ protein and is a likely candidate for drug development to treat Alzheimer's disease. 相似文献
The strategy of metal ion complexation is employed to design a delivery system for an antifouling agent (AFA) in marine paints. A poly(1-vinylimidazole-co-methyl methacrylate) copolymer (PVM), together with Cu2+ or Zn2+ formed a PVM-M2+ complex. The AFA, Medetomidine, was then coordinated into the complex. The coordination strength was investigated in solution by 1H NMR and on solid surfaces by using the Quartz Crystal Microbalance with Dissipation monitoring technique (QCM-D) and Surface Plasmon Resonance (SPR). From the 1H NMR experiments strong interactions were observed between Cu2+ and the PVM-polymer and between Medetomidine and the PVM-Cu2+ complex. From the QCM-D and SPR measurements it was shown that Cu2+, compared to Zn2+, exhibited a larger affinity for the PVM-copolymer surface that resulted in higher degree of swelling of the polymer film. Large amounts of Medetomidine were adsorbed to the PVM-Cu2+ complex resulting in low desorption rates. However, the adsorbed amount of Medetomidine was lower to the Zn2+ doped polymer and a higher desorption rate was observed. These results indicate the possibility of tuning the release of Medetomidine by altering the coordinating metal ion, which may prove to be favorable in a paint formulation. 相似文献
Aldehyde biosensors were constructed by cross-linking formaldehyde dehydrogenase (FDH) or aldehyde dehydrogenase (ADH) and bovine serum albumin on the surface of a redox Os-polymer-coated electrode. The prepared aldehyde biosensors responded rapidly (within 30 s) to aldehydes without the addition of a soluble mediator, because the inner redox Os-polymer film effectively mediated the electron transfer from NADH generated enzymatically into the outer enzyme film to a glassy carbon electrode. An FDH/Os-polymer electrode responded linearly over the concentration range of 2 x 10(-6)-5 x 10(-4) M for formaldehyde, while an ADH/Os-polymer electrode, though responding similarly to long chain aldehydes, such as propionaldehyde and butylaldehyde, responded linearly over the concentration range of 4 x 10(-6)-2 x 10(-4) M for acetaldehyde. 相似文献
Abstract The difference of the entropies of ice Ih and high-density amorphous ice and of low-density and high-density amorphous ice have been measured by a new direct method as about 2.1 and 1.1 J K?1 mol?1 respectively. 相似文献
The most burning issues worldwide at present are the availability, accessibility, and affordability of the equitable healthcare services for all. It is getting more severe for developing countries due to increasing population and chronic diseases. The emerging technological interventions in the field of Internet of Things (IoT)-based healthcare systems are a promising solution to meet the general public's healthcare needs. Therefore, an IoT-enabled vital sign monitoring system has been presented in this paper. The presented system can monitor various vital signs in real-time and store the recorded trends locally. The system can also send the data into cloud for further analysis. Abnormality detection with alert notification and automatic calculation of early warning score has been implemented. An Android application is developed to store the vital signs records on a personal server to avoid the burden and maintenance cost of the central medical server. The presented system is straightforward, compact, portable and easy to operate through personal service application. Also, the presented system is compared with the most recent work available in the field.