Structure and dynamics of ovalbumin gels

Solvent effects on dynamical and thermal behaviors of ovalbumin (OVA) gels induced by thermal denaturation at high temperature of 160°C were studied from dynamic shear modulus measurement, shear creep and creep recovery measurement, and DSC measurement. Two organic solvents, glycerin (G) and ethylene glycol (EG), and their mixtures with water (W)(G/W and EG/W) were used as solvent for preparation of gels. Stable gels formed in pure glycerin took a fractal structure at OVA concentration C range of 15–45wt% at a temperature specific to respective C, whereas a fractal structure was not observed for gels prepared in EG, G/W, and EG/W. The results were consistent with thermal denaturation behaviors of OVA in these solvents. Morphologies of two gels prepared in water and glycerin were explored using high resolution SEM, which showed that a basic unit responsible for formation of OVA gels was spheres with a diameter ranging from 20 to 40 nm, being much larger than 5.6 nm of the diameter of native OVA, and a fractal structure was related to network formation accompanied by melting of those spheres.Dedicated to Prof. John D. Ferry on the occasion of his 85th birthday.     

A highly efficient two-stage Er3+-doped optical fiberamplifier employing an optical gate to effectively reduce ASE

Highly efficient amplification of ultrashort optical pulses is demonstrated with a two-stage Er³⁺-doped optical fiber amplifier that includes an optical gate to efficiently reduce amplified spontaneous emission (ASE) generated from the first Er³⁺-doped fiber. A gain of 49 dB, an amplified peak power 0f 105 W, and 1.05 nJ pulse energy are achieved for 2-Mb/s, 10-ps pulses at a total pumping power of 90 mW from 1.48-μm LDs     

A neural network system for solving an assortment problem in the steel industry

A neural network model for solving an assortment problem found in the iron and steel industry is discussed in this paper. The problem arises in the yard where steel plate is cut into rectangular pieces. The neural network model can be categorized as a Hopfield model, but the model is expanded to handle inequality constraints. The idea of a penalty function is used. A large penalty is applied to the network if a constraint is not satisfied. The weights are updated based on the penalty values. A special term is added to the energy function of the network to guarantee the convergence of the neural network which has this feature. The performance of the neural network was evaluated by comparison with an existing expert system. The results showed that the neural network has the potential to identify in a short time near-optimal solutions to the assortment problem. The neural network is used as the core of a system for dealing with the assortment problem. In building the neural networks system for practical use, there were many implementation issues. Some of them are presented here, and the fundamental ideas are explained. The performance of the neural network system is compared to that of the expert system and evaluated from the practical viewpoint. The results show that the neural network system is useful in handling the assortment problem.     

Antitumor effect of pluronic F-127 gel containing mitomycin C on sarcoma-180 ascites tumor in mice.

Pluronic F-127 (PLF-127) gels were evaluated as a sustained-release vehicle for intraperitoneal administration of mitomycin C (MMC) in order to enhance the therapeutic effects of MMC against a Sarcoma-180 ascites tumor in mice. Tumor cell injections were made on day 0 and injections of MMC in 25% (w/w) PLF-127 on day 1, both intraperitoneally. A prolongation of the life span of tumor-bearing mice following injection of therapeutic PLF-127 was noted, and PLF-127 containing MMC was therapeutically more active than free drug. The high chemotherapeutic efficiency of MMC in PLF-127 was striking at high doses, which would be toxic in the case of the drug alone. PLF-127 gels exhibit reverse thermal behavior and are fluid at refrigerator temperature, but are soft gels at body temperature. The in vitro release experiments indicated that Pluronic gel might serve as a rate-controlling barrier and be useful as a vehicle for sustained-release preparations of MMC to be administered intraperitoneally. These results suggest that sustained-release occurs in the peritoneum and that effective drug concentrations can be maintained by the preparation.     

Cluster Properties Investigated From a Series of Ultrawideband Double Directional Propagation Measurements in Home Environments

Results from double directional ultrawideband (UWB) channel sounding in a wooden house are described. The double directional channel sounder estimates directional information at both ends of the link, so that we can separate antenna directivity from the channel sounding results. We investigated the dominant propagation mechanisms by introducing cluster analyses. The detected propagation paths from the channel sounding were first classified into clusters in the angular-delay domain, and then properties of the clusters such as standard deviation of path positions, dynamic range of path power, and power distribution of clusters were derived. From the results, we discussed the similarities and differences between the measurement environment and the physical propagation phenomena. Finally, different types of scattering losses of the propagation paths were derived and modeled. The results from sounding and analysis contribute in the development of UWB propagation models and can be used in UWB propagation simulations     

Measurement of slowly varying component in phase error distribution of a large-channel-spacing arrayed-waveguide grating

It has been difficult to measure the phase error distribution of a large-channel-spacing arrayed-waveguide grating (AWG) with optical low coherence interferometry (OLCI). In this reported work OLCI was successfully used to measure the slowly varying component in the distribution of a 1 THz-spaced AWG that was the primary filter in an ultra-high-density multi/demultiplexer. The spectral sidelobe of the AWG can be reduced by using the component to achieve the lowest possible accumulated crosstalk in the multi/demultiplexer.     

Total Synthesis of (−)‐Isoschizogamine

The total synthesis of (?)‐isoschizogamine was accomplished, featuring the construction of the quaternary carbon center by the modified Johnson–Claisen rearrangement in basic media and the facile assembly of the key tetracyclic quinolone intermediate through a cascade cyclization. The characteristic cyclic aminal was constructed by late‐stage C?H functionalization at the position adjacent to the lactam nitrogen using a combination of CrO₃ and nBu₄NIO₄ and subsequent Bi(OTf)₃‐mediated cyclization.     

Efficient and stereoselective synthesis of the disaccharide fragment of incednine

Efficient and stereoselective synthesis of a disaccharide fragment, 2-deoxy-4-O-(N'-monodemethyl-D-forosaminyl)-2-methylamino-β-D-xylopyranoside, of a novel antibiotic, incednine (1), is described. The key β-stereoselective formation of a 2,3,4,6-tetradeoxy-4-methylamino glycoside bond was achieved by remote participation-assisted glycosylation.     

Analyzing the effect of the phase-jitter in the operation of second order phase-locked loops

Phase-locked loops (PLLs) are designed to extract timing signals in telecommunication networks. Noise, cross-talk, inter-symbol interference, quantization noise, and signal distortion are responsible for oscillations in the time between two successive transitions of the clock or data signal. It appears as an accidental phase modulation superposed to the original signal. This phenomenon is called timing jitter and affects the integrity of the data recovering process and, as a consequence, the error bit rate is increased. This problem has been studied by treating the jitter as a band limited noise process and tolerance masks for the jitter amplitude and frequency are recommended for several network architectures. Here, we develop a simple model with the continuous phase deviations of the clock signals considered as periodic signals in the band of the real disturbances. Comparisons with the stochastic approach are presented.     

Injection seeding for single-mode operation in an optically pumped high-power D2O laser

Spectrally narrow, pulsed outputs consisting of almost a single mode have been obtained from an optically-pumped high-power (200kW) D₂O laser by adopting the injection seeding method, where single-mode radiation (seed pulse) from a low-power, compact D₂O laser has been injected into the main D₂O laser. Spectrally narrow outputs with high power having spectral widths as narrow as 5 MHz have been obtained, when the seed pulses with frequency tuned to one longitudinal mode of the main D₂O laser have been injected at a time sufficiently before the lasing of the main laser took place. The experimental results have been compared with those of numerical simulation modified to include the injection field with varying injection times.